Step towards Formulating a Maximum Surgical Blood Ordering Schedule in Obstetrics and Gynecology

Introduction: Blood transfusion is an essential part of perioperative care in surgeries in obstetrics and gynecology. A tendency of over ordering of blood imposes additional workload to the blood bank and extra cost to the laboratory and patients. Maximum surgical blood ordering schedule (MSBOS) is a guide which helps in the decision of ordering and transfusing blood which reduces blood wastage. This study was done with the aim of evaluating the blood ordering and utilization patterns in obstetric and gynecologic surgeries and formulation of MSBOS for these procedures for the institute. Methods: This is a cross-sectional, hospital based study conducted for the duration of three months. All patients undergoing major and minor surgeries at the department were included. Crossmatch to transfusion ratio (C/T), transfusion probability (%T), transfusion index (TI) and MSBOS were calculated for each procedure. Results: Total 309 surgeries were performed in the department during the study period of three months. Most common surgery was emergency cesarean section (n=164, 53.1%) followed by abdominal hysterectomy (n=43, 13.9%). Utilization of crossmatched blood was 22.51%. Overall transfusion rate for all surgeries was 3.88%. Overall C/T ratio, %T, and TI were 4.44, 9.83 and 0.27 respectively which elicited indiscriminate ordering of blood. Conclusion: Over ordering and under utilization of blood were seen in this audit. Blood ordering patterns need to change in order to minimize over ordering of blood which may prevent abuse of the system. MSBOS maybe an useful tool in this institute as it allows optimum blood usage for surgeries

IIT-Hyderabad team develops therapy to treat cancer

Researchers from IIT hyderabad develop combination of photothermal therapy and chemotherapy using naturally derived anticancer agen

IIT-Hyderabad develops combination therapy

Researchers from IIT Hyderabad develop combination of photothermal therapy and chemotherapy using naturally derived anticancer agen

IIT Hyderabad team uses plant extract, heat to kill cancer cells

IIT Hyderabad used chlorophyll-rich extract of a medicinal plant encapsulated in nanoparticles along with a dye to kill cancer cells when exposed to near-infrared light. The cancer cells were killed through reactive oxygen species-mediated autophagy. The extract was selective in killing only cancer cells

Wireless Charging: Its types, Standards and Applications

An electrical gadget can be powered without cords by providing electrical via an air pocket to the device in order to re-charge its capacity. The performance and practicality of cordless charging tech have noticeably enhanced lately. The introduction to cordless charging in this paper covers its basics. The evaluation of standards, which includes Qi and the A4WP, is then given, as well as a focus on their communications channels. Next, we put out a cutting-edge idea for cordless charger networking, which enables chargers to be linked for easier data gathering and management. We explain how the wireless charger network can be used to assign users to chargers, which demonstrates the usefulness in terms of a reduction costs for users to find the best chargers to recharge their mobile devices

Community Engagement in Smart Cities: A Social Network Analysis and Community Engagement Test

This study, carried out in the ever-changing context of Smart Cities, reveals the complex interactions of digital social networks, digital community involvement, and the Community involvement Test (CET) framework. The examination of data obtained from certain Smart Cities indicates a thriving milieu of community engagement, characterized by a markedly elevated rate of active participation. The identification of urgent issues, particularly those related to environmental sustainability, safety, traffic management, and educational quality, is consistent with the larger urban difficulties that these creative urban centers are facing. Additionally, the CET framework's integration of SNA data and survey results produces very high ratings, indicating the engagement programs' outstanding performance in promoting resident satisfaction and active involvement. These results highlight how digital technologies can help Smart Cities foster vibrant, engaged communities. They also highlight the continued need for smart urban policies to address urgent issues and maintain residents' quality of life while adhering to the Smart City paradigm

Real-Time Information Access in Urban Environments: A User Interaction Study Using the Real-Time Information Test

In this study, "Real-Time Information Access in Urban Environments: A User Interaction Study Using the Real-Time Information Test," participant data revealed a diverse group with an average age of 31, a balanced gender distribution, varying education levels (40% Bachelor's, 20% Master's, 40% PhD), and an average of 6 years of experience with urban navigation. The findings of the Real-Time Information Test (RTIT) showed an average job completion time of 140 seconds and a low average error count of 1.2, demonstrating competency in interacting with real-time information systems. Furthermore, the User Satisfaction Survey found an average of 8.4 overall satisfaction ratings, 8.4 user-friendliness ratings, and 7.8 information accuracy ratings, indicating excellent user experiences. These results highlight user variety, increases in job efficiency and accuracy, and high user satisfaction, all of which contribute to a comprehensive knowledge of real-time information access in urban contexts, with implications for system advancements and urban planning

Current Opinion on Food Sustainability for Liver Associated Health Problems: Facts and Myths with Case Study

The liver is the second-largest organ in our body which separates the nutrients and waste as they move through our biological process system and it additionally produces bile, a substance that carries toxins out of your body and aids in digestion. There are several myths associated with liver spread amongst masses. It is a vital necessity to make society devoid of such myths and aware of the real scenario. This review aimed to summarize the different facts and myths associated with health problems of liver and highlight the importance of food sustainability approach with the help of some case studies. A comprehensive literature search was conducted using various databases between 2006 and 2022 that focused on the various facts and myths associated with liver related health issues. Myths create nothing but false notions and fear amongst people. Some case studies were summarized to clear all the conflict statements commonly related with liver diseases in the society. Myths like nothing other than water is considered a good beverage for the liver, but recent studies have proven that measured quantities of coffee and herbal tea intake is healthy for the body. Additionally, coffee has a protective effect on the organ liver. Similarly, hepatitis can spread through casual contacts. Although it is proven that hepatitis B, C and autoimmune hepatitis, do not spread on having casual contact or sharing food and drink. A substantial myth states that blood tests can detect problems associated with the liver, but doctors rarely suggest blood tests for liver functioning. This review is focused to resolve several myths associated with the liver which are often considered true by masses

Common variants in CLDN2 and MORC4 genes confer disease susceptibility in patients with chronic pancreatitis

A recent Genome-wide Association Study (GWAS) identified association with variants in X-linked CLDN2 and MORC4 and PRSS1-PRSS2 loci with Chronic Pancreatitis (CP) in North American patients of European ancestry. We selected 9 variants from the reported GWAS and replicated the association with CP in Indian patients by genotyping 1807 unrelated Indians of Indo-European ethnicity, including 519 patients with CP and 1288 controls. The etiology of CP was idiopathic in 83.62% and alcoholic in 16.38% of 519 patients. Our study confirmed a significant association of 2 variants in CLDN2 gene (rs4409525—OR 1.71, P = 1.38 x 10-09; rs12008279—OR 1.56, P = 1.53 x 10-04) and 2 variants in MORC4 gene (rs12688220—OR 1.72, P = 9.20 x 10-09; rs6622126—OR 1.75, P = 4.04x10-05) in Indian patients with CP. We also found significant association at PRSS1-PRSS2 locus (OR 0.60; P = 9.92 x 10-06) and SAMD12-TNFRSF11B (OR 0.49, 95% CI [0.31–0.78], P = 0.0027). A variant in the gene MORC4 (rs12688220) showed significant interaction with alcohol (OR for homozygous and heterozygous risk allele -14.62 and 1.51 respectively, P = 0.0068) suggesting gene-environment interaction. A combined analysis of the genes CLDN2 and MORC4 based on an effective risk allele score revealed a higher percentage of individuals homozygous for the risk allele in CP cases with 5.09 fold enhanced risk in individuals with 7 or more effective risk alleles compared with individuals with 3 or less risk alleles (P = 1.88 x 10-14). Genetic variants in CLDN2 and MORC4 genes were associated with CP in Indian patients

Plasmodium falciparum Reticulocyte Binding-Like Homologue Protein 2 (PfRH2) Is a Key Adhesive Molecule Involved in Erythrocyte Invasion

Erythrocyte invasion by Plasmodium merozoites is a complex, multistep process that is mediated by a number of parasite ligand-erythrocyte receptor interactions. One such family of parasite ligands includes the P. falciparum reticulocyte binding homologue (PfRH) proteins that are homologous with the P. vivax reticulocyte binding proteins and have been shown to play a role in erythrocyte invasion. There are five functional PfRH proteins of which only PfRH2a/2b have not yet been demonstrated to bind erythrocytes. In this study, we demonstrated that native PfRH2a/2b is processed near the N-terminus yielding fragments of 220 kDa and 80 kDa that exhibit differential erythrocyte binding specificities. The erythrocyte binding specificity of the 220 kDa processed fragment of native PfRH2a/2b was sialic acid-independent, trypsin resistant and chymotrypsin sensitive. This specific binding phenotype is consistent with previous studies that disrupted the PfRH2a/2b genes and demonstrated that PfRH2b is involved in a sialic acid independent, trypsin resistant, chymotrypsin sensitive invasion pathway. Interestingly, we found that the smaller 80 kDa PfRH2a/2b fragment is processed from the larger 220 kDa fragment and binds erythrocytes in a sialic acid dependent, trypsin resistant and chymotrypsin sensitive manner. Thus, the two processed fragments of PfRH2a/2b differed with respect to their dependence on sialic acids for erythrocyte binding. Further, we mapped the erythrocyte binding domain of PfRH2a/2b to a conserved 40 kDa N-terminal region (rPfRH240) in the ectodomain that is common to both PfRH2a and PfRH2b. We demonstrated that recombinant rPfRH240 bound human erythrocytes with the same specificity as the native 220 kDa processed protein. Moreover, antibodies generated against rPfRH240 blocked erythrocyte invasion by P. falciparum through a sialic acid independent pathway. PfRH2a/2b thus plays a key role in erythrocyte invasion and its conserved receptor-binding domain deserves attention as a promising candidate for inclusion in a blood-stage malaria vaccine