Squamous cell carcinoma arising from teratoma of the ovary: magnetic resonance, computed tomography, and pathological findings

WOS: 000396648700029PubMed: 29767884In the present case report, the authors investigated the clinicopathological characteristics of squamous cell carcinoma (SCC) arising from teratoma of the ovary and intended to report their clinical experience. Malignant transformation of ovarian teratoma is a quite rare condition with SCC observed to be the most common form of transformation. the present case was a 43-year-old female patient and her clinical presentation was abdominal pain, abdominal distension, and abdominal mass sensation. the patient underwent ultrasonography. After detection of a mass, magnetic resonance imaging (MRI) was performed. Surgery was performed on the patient and the pathological report revealed SCC arising from teratoma. the patient was evaluated retrospectively in terms of demographic characteristics, MRI, surgical findings, and prognosis

The effect of gadolinium-based contrast agents on rat testis

Mercantepe, Tolga/0000-0002-8506-1755; INECIKLI, MEHMET FATIH/0000-0002-9796-8223; yilmaz, adnan/0000-0003-4842-1173; TUMKAYA, Levent/0000-0002-2814-5194WOS: 000438889600019PubMed: 29700836Previous studies have reported that repeated administrations of linear gadolinium-based contrast agents lead to their accumulation in the brain and other tissues in individuals with normal renal functions. the purpose of this prospective animal study was to investigate the effect of multiple administrations of macrocyclic ionic (gadoteric acid) and linear nonionic (gadodiamide) gadolinium-based contrast agents (GBCAs) on rat testis tissue and to compare these molecules in terms of tissue damage. Thirty-two male Sprague-Dawley rats were kept without drugs for 5weeks after administration of 0.1mmol mg(-1) kg(-1) (0.2ml/kg) gadodiamide and gadoteric acid for 4days over 5weeks. Biochemical, histopathological and immunohistochemical changes in testis tissue were evaluated at the end of 10weeks. When used in repeated clinical doses, gadolinium was observed to increase apoptosis in the Leydig cells of the rat testis, and to increase serum Ca+2 levels and reduce testosterone levels (p.05). Both linear and macrocyclic contrast agents have toxic effects on testis tissue, irrespective of the type of drug.Recep Tayyip Erdogan University Scientific Research Projects Coordination UnitRecep Tayyip Erdogan University [TSA-2016-559]We confirm that all of the materials needed for this experimental study was derived from Recep Tayyip Erdogan University Scientific Research Projects Coordination Unit (code: TSA-2016-559)

Relationship of osteoprotegerin to pulse wave velocity and carotid intima-media thickness in rheumatoid arthritis patients

Cure, Medine Cumhur/0000-0001-9253-6459; Serdaroglu Beyazal, Munevver/0000-0001-5903-5708; Erdogan, Turan/0000-0003-2986-5457WOS: 000382921900011PubMed: 26555551Osteoprotegerin (OPG) is considered an important biomarker in cardiovascular (CV) disease. CV disease is the most common cause of mortality in patients with rheumatoid arthritis (RA), a consequence of accelerated atherosclerosis. the present study aimed to evaluate the relationship of serum OPG levels to arterial stiffness, carotid intima-media thickness (CIMT), and clinical and laboratory indices in RA patients. Included in the study were 68 RA patients with no history or signs of CV disease and 48 healthy subjects Disease activity was assessed by the 28-joint disease activity score (DAS28) in RA patients. Serum OPG level was measured using enzyme-linked immunosorbent assay (ELISA). Carotid femoral pulse wave velocity (PWV) was measured as an index of arterial stiffness and CIMT was evaluated by carotid ultrasonography. the mean serum OPG level was significantly higher in RA patients than controls (p < 0.001). Mean PWV and CIMT were also significantly increased in RA patients compared to controls (both p < 0.001). in RA patients, serum OPG level was significantly correlated with PWV and CIMT, as well as rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody; but not with DAS28, high-sensitivity C-reactive protein (hsCRP), or erythrocyte sedimentation rate. Serum OPG levels were increased and correlated with CIMT and PWV in RA patients. in addition to PWV and CIMT, OPG may be a useful biomarker for CV risk management in RA patients

The effect of gadolinium-based contrast agents on rat testis

PMID = 2970083

Coexistence of Systemic Lupus Erythematosus and Familial Mediterranean Fever

Serdaroglu Beyazal, Munevver/0000-0001-5903-5708WOS: 000349638900019PubMed: 25416696[No abstract available

Assessment of hand function and disability in fibromyalgia

Serdaroglu Beyazal, Munevver/0000-0001-5903-5708WOS: 000494049400012PubMed: 30324279Objective. Fibromyalgia, a potentially debilitating chronic pain syndrome, is a chronic disease. We aimed to compare the hand function of fibromyalgia (FM) patients and healthy individuals and to demonstrate the relationship between hand disability and FM. Patients and methods. the study was consisted of 40 female patients with FM and 30 healthy controls. All participants were evaluated for pain threshold measurements, handgrip strength, and pinch strength. Functional states, hand disability, and hand skills and coordination were evaluated using the Fibromyalgia Impact Questionnaire (FIQ) form, the Disability of Arm-Shoulder-Hand (DASH) questionnaire and the Purdue Pegboard Test, respectively. Results. Handgrip strength values, DASH score, lateral pinch strength test, Pegboard placement time, and Pegboard collection time of the patient group were significantly lower than those of the control group (all p < 0.05). A negative correlation was found between FIQ score and handgrip strength, two-point pinch strength test, three-point pinch strength test, and lateral pinch strength test in patients with moderate FM (all p < 0.05). Furthermore, a correlation was observed between DASH score and handgrip strength, lateral pinch strength test, Purdue Pegboard placement time, and Purdue Pegboard collection time in patients with moderate FM (all p < 0.05). Conclusions. Our results show that hand function was decreased in patients with FM compared to healthy controls and decreasing hand function was influenced by FIQ score. As a result, the evaluation of hand function should be taken into consideration in the management of FM

Medial olivocochlear reflex in ankylosing spondylitis patients

Celiker, Metin/0000-0002-9833-402X; Serdaroglu Beyazal, Munevver/0000-0001-5903-5708WOS: 000389354800011PubMed: 27312462Ankylosing spondylitis (AS) is a chronic systemic inflammatory disease. Via autoimmune mediators, AS can damage the auditory system similar to other systems. Otoacoustic emission studies in AS patients showed that the damage that causes hearing loss was in the outer hair cells. the medial olivocochlear (MOC) reflex is used to evaluate the MOC efferent system (MOES), which includes the outer hair cells. the aim of this study was to evaluate the presence of subclinical damage in the inner ear with the aid of the MOC reflex test in AS patients with no hearing complaints. Thirty-four patients with AS and a control group of 30 healthy volunteers with similar demographic characteristics were evaluated in the study. Otoacoustic emission responses, MOC reflex results, and frequency-specific and total suppression findings were compared between the groups. the relationship between clinical and laboratory findings for the AS patients, and the MOC reflex data were also investigated. Reduced MOC reflex response (p = 0.04) and suppression (p = 0.019) were detected in AS patients. When the clinical and laboratory findings for the AS patients and the MOC reflex test results were compared, a significant correlation was found only between the MOC reflex and the erythrocyte sedimentation rate. the results showed that AS can damage the inner ear, especially the MOES, and can reduce the MOC reflex response without clinical hearing loss

Serum Levels of IL-17, IL-6, TNF-alpha and Disease Activity in Patients with Rheumatoid Arthritis

WOS: 000409185000008Objective the aim of this study was to evaluate serum levels of interleukin (IL)-17, IL-6, and tumor necrosis factor alpha (TNF-alpha) in RA patients and to assess the correlation of these cytokines with clinical and laboratory parameters. Materials and Methods 48 patients with RA and 35 healthy volunteers were enrolled in the study. Disease activity was determined by disease activity score (DAS28) in patients with RA. Patients with RA were categorized as mild (DAS28 0.05). Serum IL-6 levels were significantly elevated in RA patients compared with controls (P < 0.001). the increasing trend in mean serum IL-6 levels across group with mild, moderate, and severe disease activity was significant (P < 0.001, respectively). in RA patients, serum IL-6 concentrations were significantly correlated with ESR, CRP, DAS28, and VAS (r = 0.371, P = 0.009; r = 0.519, P < 0.001; r = 0.536, P < 0.001; r = 0.539, P < 0.001, respectively). Also, Serum IL-17 concentrations demonstrated significant correlations with ESR, CRP, but not DAS28 (r = 0.349, P = 0.015; r = 0.299, P = 0.039; r = 0.274, P = 0.060, respectively). Serum TNF-alpha showed no significant correlation with disease activity indices. Conclusions This study showed that patients with RA had significantly increased cytokine level for IL-6, but not IL-17 and TNF-alpha and high level of serum IL-6 cytokine was associated with disease activity. However, further follow-up studies involving large samples are required to clarify precise role of these cytokines in disease development and progress

MEDIAL OLIVOCOCHLEAR REFLEX IN PATIENTS WITH ANKYLOSING SPONDYLITIS

Annual European Congress of Rheumatology (EULAR) -- JUN 08-11, 2016 -- London, ENGLANDWOS: 000401523105452[No abstract available