Nevirapine- Versus Lopinavir/Ritonavir-Based Initial Therapy for HIV-1 Infection among Women in Africa: A Randomized Trial

In a randomized control trial, Shahin Lockman and colleagues compare nevirapine-based therapy with lopinavir/ritonavir-based therapy for HIV-infected women without previous exposure to antiretroviral treatment

A Latin American Perspective to Agricultural Ethics

The mixture of political, social, cultural and economic environments in Latin America, together with the enormous diversity in climates, natural habitats and biological resources the continent offers, make the ethical assessment of agricultural policies extremely difficult. Yet the experience gained while addressing the contemporary challenges the region faces, such as rapid urbanization, loss of culinary and crop diversity, extreme inequality, disappearing farming styles, water and land grabs, malnutrition and the restoration of the rule of law and social peace, can be of great value to other regions in similar latitudes, development processes and social problems. This chapter will provide a brief overview of these challenges from the perspective of a continent that is exposed to the consequences of extreme inequality in multiple dimensions and conclude by arguing for the need to have a continuous South-South dialogue on the challenges of establishing socially and environmentally sustainable food systems

Double Negative (CD3+4−8−) TCRαβ Splenic Cells from Young NOD Mice Provide Long-Lasting Protection against Type 1 Diabetes

-reactive T-cells. Herein, we analyzed the function and phenotype of DNCD3 splenic cells in young NOD mice predisposed to several autoimmune disorders among which, the human-like autoimmune diabetes. with a predominant Vβ13 gene usage.T-regulatory cells. DNCD3 splenic cells could be potentially manipulated towards the development of autologous cell therapies in autoimmune diabetes

Assessing spatial associations between perceptions of landscape value and climate change risk for use in climate change planning

This study examines spatially referenced perceived landscape values and climate change risks collected through public participation geographic information systems for potential use in climate change planning. Using survey data from the Southern Fleurieu Peninsula, South Australia, we present a method for identifying perceived landscape values and climate change risks to describe and quantify their spatial associations. Two spatial data models—vector and raster—and two analytical methods—Jaccard coefficients and spatial cross-correlations were used to describe the spatial associations. Results indicate that perceptions of climate change risk are driven, in part, by the values people assign or hold for places on the landscape. Biodiversity and intrinsic landscape values have strong spatial association with biodiversity loss risk while recreation values have strong spatial association with riparian flooding, sea-level rise and wave action risks. Other landscape values show weak to no spatial association with perceived climate change risks. The methodology described in this research provides a mechanism for government agencies to develop place-based adaptation strategies based on these associations