The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep (Ovis aries)

Much of our knowledge of the drivers of immune variation, and how these responses vary over time, comes from humans, domesticated livestock or laboratory organisms. While the genetic basis of variation in immune responses have been investigated in these systems, there is a poor understanding of how genetic variation influences immunity in natural, untreated populations living in complex environments. Here, we examine the genetic architecture of variation in immune traits in the Soay sheep of St Kilda, an unmanaged population of sheep infected with strongyle gastrointestinal nematodes. We assayed IgA, IgE and IgG antibodies against the prevalent nematode Teladorsagia circumcincta in the blood plasma of > 3,000 sheep collected over 26 years. Antibody levels were significantly heritable (h2 = 0.21 to 0.57) and highly stable over an individual’s lifespan. IgA levels were strongly associated with a region on chromosome 24 explaining 21.1% and 24.5% of heritable variation in lambs and adults, respectively. This region was adjacent to two candidate loci, Class II Major Histocompatibility Complex Transactivator (CIITA) and C-Type Lectin Domain Containing 16A (CLEC16A). Lamb IgA levels were also associated with the immunoglobulin heavy constant loci (IGH) complex, and adult IgE levels and lamb IgA and IgG levels were associated with the major histocompatibility complex (MHC). This study provides evidence of high heritability of a complex immunological trait under natural conditions and provides the first evidence from a genome-wide study that large effect genes located outside the MHC region exist for immune traits in the wild

Feeding of Broken Rice to White Pekin Ducks

Not AvailableA study was conducted in the tropical coastal region of Odisha in 2019 to find out the effect of replacing wheat with broken rice (BR) on nutrients metabolisability, egg production and quality in White Pekin ducks. White Pekin ducks (45, 165 days) were divided into three groups with three replicates in each group and each replicate has five ducks. Three experimental diets without (BR-0) and with BR, replacing 50 (BR-50) and 100 (BR-100), percent wheat were prepared. The above diets were offered randomly to the above groups till the birds attended 40 weeks followed by conduction of a metabolic trial. The dry matter intake (g/d) was similar among the groups. The metabolisability percentage of dry matter, organic matter, crude protein, ether extract and crude fibre in BR-0 and BR-50 were similar and higher than BR-100. There was no significant difference in N balance (g/d) among the groups. The total egg production, duck day egg production percentage and feed conversion ratio were similar among the groups. The external and internal egg quality parameters were similar among the groups. It can be concluded that wheat can be replaced with broken at 50% level in the diets of white Pekin ducks during first phase of laying under intensive rearing system with increase in the metabolisability of the nutrients of the feed without affecting the performance.Indian Council of Agricultural Research, New Delh

Not Available

Not AvailableNot AvailableIndian Council of Agricultural Research, New Delh

US immigration Westernizes the human gut microbiome

Many US immigrant populations develop metabolic diseases post immigration, but the causes are not well understood. Although the microbiome plays a role in metabolic disease, there have been no studies measuring the effects of US immigration on the gut microbiome. We collected stool, dietary recalls, and anthropometrics from 514 Hmong and Karen individuals living in Thailand and the United States, including first- and second-generation immigrants and 19 Karen individuals sampled before and after immigration, as well as from 36 US-born European American individuals. Using 16S and deep shotgun metagenomic DNA sequencing, we found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions. These effects increase with duration of US residence and are compounded by obesity and across generations

US immigration Westernizes the human gut microbiome

Many US immigrant populations develop metabolic diseases post immigration, but the causes are not well understood. Although the microbiome plays a role in metabolic disease, there have been no studies measuring the effects of US immigration on the gut microbiome. We collected stool, dietary recalls, and anthropometrics from 514 Hmong and Karen individuals living in Thailand and the United States, including first- and second-generation immigrants and 19 Karen individuals sampled before and after immigration, as well as from 36 US-born European American individuals. Using 16S and deep shotgun metagenomic DNA sequencing, we found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions. These effects increase with duration of US residence and are compounded by obesity and across generations