The interaction of polymer surfaces with blood

Some general aspects of the interaction of foreign materials with blood are summarized. The role of protein adsorption in this interaction is briefly discussed. In an attempt to produce more stable antithrombogenic surface coatings than the well-known heparin-bonded surfaces, a method is described in which a high-molecular-weight polyelectrolyte is bound to polymer surfaces. In vitro experiments carried out with freshly drawn human blood show a reduced platelet adhesion on such surfaces

Finite-size scaling of eigenstate thermalization

According to the eigenstate thermalization hypothesis (ETH), even isolated quantum systems can thermalize because the eigenstate-to-eigenstate fluctuations of typical observables vanish in the limit of large systems. Of course, isolated systems are by nature finite, and the main way of computing such quantities is through numerical evaluation for finite-size systems. Therefore, the finite-size scaling of the fluctuations of eigenstate expectation values is a central aspect of the ETH. In this work, we present numerical evidence that for generic non-integrable systems these fluctuations scale with a universal power law $D^{-1/2}$ with the dimension $D$ of the Hilbert space. We provide heuristic arguments, in the same spirit as the ETH, to explain this universal result. Our results are based on the analysis of three families of models, and several observables for each model. Each family includes integrable members, and we show how the system size where the universal power law becomes visible is affected by the proximity to integrability.Comment: 9 pages, 8 figures; accepted for publication in Phys. Rev.

Proteins involved in the Vroman effect during exposure of human blood plasma to glass and polyethylene

The amounts of fibrinogen adsorbed to glass from various human blood plasmas have been measured as a function of time. The plasmas were 11 single donor plasmas, pooled plasma, a single donor high molecular weight kininogen (HMWK)-deficient plasma and HMWK-deficient plasma, which had been reconstituted with HMWK. For adsorption times between 1 min and 1 h more fibrinogen adsorbed from HMWK-deficient plasma compared with the amounts of fibrinogen which adsorbed from the other plasmas. This result supports the conclusion of several authors that HMWK is involved in the displacement of fibrinogen, initially adsorbed from normal human plasma to glass. Glass surfaces, pre-exposed to solutions of plasma and subsequently exposed to 1:1 diluted plasma, gives rise to a relatively high adsorption of HMWK which is independent of the plasma concentration of the precoating solution. The results indicate that HMWK from 1:1 diluted plasma is involved in the displacement of proteins from glass surfaces which had been pre-exposed to solutions with a low plasma concentration. Experiments with polyethylene as a substrate reveal that high density lipoprotein (HDL) from 1:1 diluted plasma is involved in the displacement of proteins from polyethylene surfaces which had been pre-exposed to solutions with a low plasma concentration. Moreover, evidence is presented that substantial amounts of albumin and fibrinogen, adsorbed from 1:1000 diluted plasma to glass and polyethylene, are displaced from the surfaces of these materials by proteins from 1:1 diluted plasma different from HMWK and HDL

Off-diagonal matrix elements of local operators in many-body quantum systems

In the time evolution of isolated quantum systems out of equilibrium, local observables generally relax to a long-time asymptotic value, governed by the expectation values (diagonal matrix elements) of the corresponding operator in the eigenstates of the system. The temporal fluctuations around this value, response to further perturbations, and the relaxation toward this asymptotic value, are all determined by the off-diagonal matrix elements. Motivated by this non-equilibrium role, we present generic statistical properties of off-diagonal matrix elements of local observables in two families of interacting many-body systems with local interactions. Since integrability (or lack thereof) is an important ingredient in the relaxation process, we analyze models that can be continuously tuned to integrability. We show that, for generic non-integrable systems, the distribution of off-diagonal matrix elements is a gaussian centered at zero. As one approaches integrability, the peak around zero becomes sharper, so that the distribution is approximately a combination of two gaussians. We characterize the proximity to integrability through the deviation of this distribution from a gaussian shape. We also determine the scaling dependence on system size of the average magnitude of off-diagonal matrix elements.Comment: 10 pages, 6 figure

Topological phase transitions driven by next-nearest-neighbor hopping in two-dimensional lattices

For two-dimensional lattices in a tight-binding description, the intrinsic spin-orbit coupling, acting as a complex next-nearest-neighbor hopping, opens gaps that exhibit the quantum spin Hall effect. In this paper, we study the effect of a real next-nearest-neighbor hopping term on the band structure of several Dirac systems. In our model, the spin is conserved, which allows us to analyze the spin Chern numbers. We show that in the Lieb, kagome, and T_3 lattices, variation of the amplitude of the real next-nearest-neighbor hopping term drives interesting topological phase transitions. These transitions may be experimentally realized in optical lattices under shaking, when the ratio between the nearest- and next-nearest-neighbor hopping parameters can be tuned to any possible value. Finally, we show that in the honeycomb lattice, next-nearest-neighbor hopping only drives topological phase transitions in the presence of a magnetic field, leading to the conjecture that these transitions can only occur in multigap systems.Comment: 10 pages, 9 figures [erratum: corrected colors in Fig. 7(a)

Detection of surface-adsorbed (lipo)proteins by means of a two-step enzyme-immunoassay: a study on the Vroman effect

In view of reports on the involvement of high-molecular-weight (HMW) kininogen and high-density lipoprotein (HDL) in the Vroman effect, we studied the adsorption of fibrinogen, HMW kininogen, HDL and several other proteins from pooled human plasma and congenitally HMW kininogen-deficient plasma onto glass and low-density polyethylene, both as a function of the plasma concentration and the contact time. Mixtures of purified (lipo)proteins were also included in the study. Protein adsorption was determined by means of a two-step enzyme-immunoassay. Our results support the hypothesis that HMW kininogen is involved in the displacement of fibrinogen, which is almost instantly adsorbed from normal plasma onto glass. On hydrophobic polymers like polyethylene, the low amounts of adsorbed fibrinogen and HMW kininogen from plasma and concentrated plasma solutions may be due to a preferential adsorption of HDL

Thin-layer chromatography of pigments from reaction center particles of Rhodopseudomonas spheroides

1. Pigments extracted from reaction center particles of Rhodopseudomonas spheroides were separated and identified by means of thin-layer chromatography.\ud \ud 2. The results strongly suggest that bacteriochlorophyll a is the only bacteriochlorophyll pigment present in reaction centers.\ud \ud 3. Other compounds identified are bacteriopheophytin a, ubiquinone-10 and spheroidene

Topological phases in a two-dimensional lattice: Magnetic field versus spin-orbit coupling

In this work, we explore the rich variety of topological states that arise in two-dimensional systems, by considering the competing effects of spin-orbit couplings and a perpendicular magnetic field on a honeycomb lattice. Unlike earlier approaches, we investigate minimal models in order to clarify the effects of the intrinsic and Rashba spin-orbit couplings, and also of the Zeeman splitting, on the quantum Hall states generated by the magnetic field. In this sense, our work provides an interesting path connecting quantum Hall and quantum spin Hall physics. First, we consider the properties of each term individually and we analyze their similarities and differences. Secondly, we investigate the subtle competitions that arise when these effects are combined. We finally explore the various possible experimental realizations of our model.Comment: 19 pages, 15 figure

Genesis of the Floquet Hofstadter butterfly

We investigate theoretically the spectrum of a graphene-like sample (honeycomb lattice) subjected to a perpendicular magnetic field and irradiated by circularly polarized light. This system is studied using the Floquet formalism, and the resulting Hofstadter spectrum is analyzed for different regimes of the driving frequency. For lower frequencies, resonances of various copies of the spectrum lead to intricate formations of topological gaps. In the Landau-level regime, new wing-like gaps emerge upon reducing the driving frequency, thus revealing the possibility of dynamically tuning the formation of the Hofstadter butterfly. In this regime, an effective model may be analytically derived, which allows us to retrace the energy levels that exhibit avoided crossings and ultimately lead to gap structures with a wing-like shape. At high frequencies, we find that gaps open for various fluxes at $E=0$, and upon increasing the amplitude of the driving, gaps also close and reopen at other energies. The topological invariants of these gaps are calculated and the resulting spectrum is elucidated. We suggest opportunities for experimental realization and discuss similarities with Landau-level structures in non-driven systems.Comment: 8 pages, 4 figure