126 research outputs found
The estimation of black-hole masses in distant radio galaxies
We have estimated the masses of the central supermassive black holes of 2442
radio galaxies froma catalog compiled using data from the NED, SDSS, and CATS
databases. Mass estimates based on optical photometry and radio data are
compared. Relationships between the mass of the central black hole
and the redshift are constructed for both wavelength ranges. The
distribution of the galaxies in these diagrams and systematic effects
influencing estimation of the black-hole parameters are discussed.
Upperenvelope cubic regression fits are obtained using the maximum estimates of
the black-hole masses. The optical and radio upper envelopes show similar
behavior, and have very similar peaks in position, , and
amplitude, = 9.4. This is consistent with a model in which the
growth of the supermassive black holes is self-regulating, with this redshift
corresponding to the epoch when the accretion-flow phase begins to end and the
nuclear activity falls off.Comment: 8 pages, 6 figure
Halloween, Organization, and the Ethics of Uncanny Celebration
This article examines the relationship between organizational ethics, the uncanny, and the annual celebration of Halloween. We begin by exploring the traditional and contemporary organizational function of Halloween as ‘tension-management ritual’ (Etzioni, Sociol Theory 18(1):44–59, 2000) through which collective fears, anxieties, and fantasies are played out and given material expression. Combining the uncanny with the folkloric concept of ostension, we then examine an incident in which UK supermarket retailers made national news headlines for selling offensive Halloween costumes depicting ‘escaped mental patients’. Rather than treating this incident as a problem of moral hygiene—in which products are removed, apologies made, and lessons learned—we consider the value of Halloween as a unique and disruptive ethical encounter with the uncanny Other. Looking beyond its commercial appeal and controversy, we reflect on the creative, generous, and disruptive potential of Halloween as both tension-management ritual and unique organizational space of hospitality through which to receive and embrace alterity and so discover the homely within the unheimlich
Enhanced killing of androgen-independent prostate cancer cells using inositol hexakisphosphate in combination with proteasome inhibitors
Effective treatments for androgen-independent prostate cancer (AIPCa) are lacking. To address this, emerging therapeutics such as proteasome inhibitors are currently undergoing clinical trials. Inositol hexakisphosphate (IP6) is an orally non-toxic phytochemical that exhibits antitumour activity against several types of cancer including PCa. We have previously shown that treatment of PC3 cells with IP6 induces the transcription of a subset of nuclear factor-κB (NF-κB)-responsive and pro-apoptotic BCL-2 family genes. In this study, we report that although NF-κB subunits p50/p65 translocate to the nucleus of PC3 cells in response to IP6, inhibition of NF-κB-mediated transcription using non-degradable inhibitor of κB (IκB)-α does not modulate IP6 sensitivity. Treatment with IP6 also leads to increased protein levels of PUMA, BIK/NBK and NOXA between 4 and 8 h of treatment and decreased levels of MCL-1 and BCL-2 after 24 h. Although blocking transcription using actinomycin D does not modulate PC3 cell sensitivity to IP6, inhibition of protein translation using cycloheximide has a significant protective effect. In contrast, blocking proteasome-mediated protein degradation using MG-132 significantly enhances the ability of IP6 to reduce cellular metabolic activity in both PC3 and DU145 AIPCa cell lines. This effect of combined treatment on mitochondrial depolarisation is particularly striking and is also reproduced by another proteasome inhibitor (ALLN). The enhanced effect of combined MG132/IP6 treatment is almost completely inhibited by cycloheximide and correlates with changes in BCL-2 family protein levels. Altogether these results suggest a role for BCL-2 family proteins in mediating the combined effect of IP6 and proteasome inhibitors and warrant further pre-clinical studies for the treatment of AIPCa
Controle e coerção: a pedagogia do olhar na espacialidade do teatro e das organizações
Elements of chemistry : for the use of colleges, academies, and schools /
Includes index.Mode of access: Internet
Elements of chemistry: for the use of colleges, academies, and schools. Illus. by nearly seven hundred wood-cuts. Tr. from the French, by T. Forrest Betton ... and ed. with notes, by James C. Booth ... and William L. Faber. To which is appended a comparative table of French and English weights and measures.
2 v. illus., 2 fold. pl., tables. 24 cm
Characterization of an intermediate in the folding pathway of phosphoglycerate kinase: Chemical reactivity of genetically introduced cysteinyl residues during the folding process
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