1 research outputs found
DNA Origami Nanoantennas with over 5000-fold Fluorescence Enhancement and Single-Molecule Detection at 25 μM
Optical nanoantennas are known to
focus freely propagating light and reversely to mediate the emission
of a light source located at the nanoantenna hotspot. These effects
were previously exploited for fluorescence enhancement and single-molecule
detection at elevated concentrations. We present a new generation
of self-assembled DNA origami based optical nanoantennas with improved
robustness, reduced interparticle distance, and optimized quantum-yield
improvement to achieve more than 5000-fold fluorescence enhancement
and single-molecule detection at 25 μM background fluorophore
concentration. Besides outperforming lithographic optical antennas,
DNA origami nanoantennas are additionally capable of incorporating
single emitters or biomolecular assays at the antenna hotspot