12 research outputs found
Mo1881 Onset of Action and Efficiency of STW 5 in the Clinical Setting in Patients With Functional Dyspepsia and Irritable Bowel Syndrome
No full textThe Herbal Preparation STW 5 for the Treatment of Functional Gastrointestinal Diseases in Children Aged 3-14 Years – A Prospective Non Interventional Study
No full textMo1885 A Survey of Treatment of Patients With Functional Dyspepsia in the Routine Clinical Setting
No full textT1251 Effects of STW 5 and Some of Its Components On Spontaneous Contractions in Mouse Ileum In Vitro
No full textT1037 Structural Validation of a Quality of Life Questionnaire (FDDQOL) in Patients with Functional Dyspepsia - Reevaluation of a Placebo-Controlled Trial
No full textM1802 Herbal Preparation STW 5 Improved Quality of Life in Patients with Functional Dyspepsia - Results of a Placebo-Controlled Trial
No full textT2015 Do Phytomedicines Widely Used in FGID Have Anti-Proliferative and Proapoptotic Effects in Colon Adenocarcinoma Cells?
No full textSu1899 Receptor Modulation and MAP-Kinase Signaling Induced by STW5 and by the Proton-Pump Inhibitor Omeprazol in a Rat Model for Gastroesophageal Reflux Disease and in HET1A-Cells
No full textTu1440 Discovering New Underlying Mechanisms in the Treatment of Functional Dyspepsia With the Herbal Preparation, STW5 Using a Novel Sequential Stress Model
No full textA leucine zipper in the N terminus confers membrane association to SLP-65
No full textMembrane recruitment of adaptor proteins is crucial for coupling antigen receptors to downstream signaling events. Despite the essential function of the B cell adaptor SLP-65, the mechanism of its recruitment to the plasma membrane is not yet understood. Here we show that a highly conserved leucine zipper in the SLP-65 N terminus is responsible for membrane association. Alterations in the N terminus abolished SLP-65 membrane localization and activity, both of which were restored by replacement of the N terminus with a myristoylation signal. The N terminus is an autonomous domain that confers specific localization and function when transferred to green fluorescent protein or the adaptor protein SLP-76. Our data elucidate the mechanism of SLP-65 membrane recruitment and suggest that leucine zipper motifs are essential interaction domains of signaling proteins
