Time-resolved searchlight analysis of imagined visual motion using 7T ultra-high field fMRI: Data on interindividual differences

AbstractInterindividual differences play a crucial role in research on mental imagery. The inherently private nature of imagery does not allow for the same experimental control that is possible in perception research. Even when there are precise instructions subjects will differ in their particular imagery strategy and, hence, show different brain activations. Here, we show results of a time-resolved searchlight analysis for 12 individual subjects who perform a visual motion imagery task. The data show the spatial and temporal extent of brain areas and time windows that allow for a successful decoding of the direction of imagined motion out of four options. Accuracy maps for six different time windows are shown for every individual subject and are made freely available on NeuroVault. These data accompany the findings in the publication “Decoding the direction of imagined visual motion using 7T ultra-high field fMRI” (Emmerling et al., 2016) [1]

Increasing the competitiveness of e-vehicles in Europe

Introduction This paper is concerned with incentives for the take-up and use of e-vehicles that are in place in different European countries. Especially, it analyses Norway and Austria, in order to establish and understand factors influencing the competitiveness of e-vehicles and potential market penetration. Norway currently enjoys the world’s largest take-up of electric cars per capita, achieved through an extensive package of incentives. Austria has used the concept of Model Regions with government support to stimulate market introduction. So far, this has been a less effective approach. Methods The paper brings in and combine analyses of national travel survey data and web surveys to e-vehicle owners and non-e-vehicle owners. It considers socio-economic factors including convenience and time savings due to e-vehicle policies. Results Analysing national travel surveys, we find a considerable potential for e-vehicles based on people’s everyday travel. Social networks play a crucial role in spreading knowledge about this relatively new technology. The take-up of battery electric vehicles correlates relatively closely with the user value of e-vehicle incentives. The fiscal effects of e-vehicle incentives are non-trivial – especially in the longer run. The cost of lifting a new technology into the market by means of government incentives is significant. We point to the importance of a strategy for the gradual phasing out of e-vehicle policies in countries with large incentives when the cost of vehicles goes down and the technology improves. Conclusions Successful market uptake and expansion of electric vehicles requires massive, expensive and combined policies. Central government backing, long term commitment and market-oriented incentives help reduce the perceived risk for market players like car importers and allow the e-vehicle market to thrive. For countries with low e-vehicle market shares the potential is promising. Battery electric vehicles are already a real option for the majority of peoples’ everyday trips and trip chains. However, their relative disadvantages must be compensated by means of incentives – at least in the initial market launch phase. Diffusion mechanisms play a sizeable role. The lack of knowledge in the population at large must be addressed

Asymmetric Rh diene catalysis under confinement : isoxazole ring‐contraction in mesoporous solids

Covalent immobilization of chiral dienes in mesoporous solids for asymmetric heterogeneous catalysis is highly attractive. In order to study confinement effects in bimolecular vs monomolecular reactions, a series of pseudo‐C2‐symmetrical tetrahydropentalenes was synthesized and immobilized via click reaction on different mesoporous solids (silica, carbon, covalent organic frameworks) and compared with homogeneous conditions. Two types of Rh‐catalyzed reactions were studied: (a) bimolecular nucleophilic 1,2‐additions of phenylboroxine to N‐tosylimine and (b) monomolecular isomerization of isoxazole to 2H‐azirne. Polar support materials performed better than non‐polar ones. Under confinement, bimolecular reactions showed decreased yields, whereas yields in monomolecular reactions were only little affected. Regarding enantioselectivity the opposite trend was observed, i. e. effective enantiocontrol for bimolecular reactions but only little control for monomolecular reactions was found.Deutsche Forschungsgemeinschaf

NO as a Reagent for Topochemical Framework Transformation and Controlled Nitric Oxide Release in Covalent Organic Frameworks

Covalent organic frameworks (COFs) have emerged as versatile platforms for the separation and storage of hazardous gases. Simultaneously, the synthetic toolbox to tackle the “COF trilemma” has been diversified to include topochemical linkage transformations and post-synthetic stabilization strategies. Herein, we converge these themes and reveal the unique potential of NO as a new reagent for the scalable gas-phase transformation of COFs. Using physisorption and solid-state nuclear magnetic resonance spectroscopy on 15N-enriched COFs, we study the gas uptake capacity and selectivity of NO adsorption and unravel the interactions of NO with COFs. Our study reveals the clean deamination of terminal amine groups on the particle surfaces by NO, exemplifying a unique surface passivation strategy for COFs. We further describe the formation of a NONOate-linkage by the reaction of NO with an amine-linked COF, which shows controlled release of NO under physiological conditions. NONOate-COFs thus show promise as tunable NO delivery platforms for bioregulatory NO release in biomedical applications

Isopropyl 2,3,4,6-tetra-O-acetyl-β-d-glucopyranoside

The title compound, C17H26O10, was formed by a Koenigs–Knorr reaction of 2,3,4,6-tetra-O-acetyl-α-d-glucopyranosyl bromide and propan-2-ol. The central ring adopts a chair conformation. The crystal does not contain any significant intermolecular interactions

Interlayer Interactions as Design Tool for Large-Pore COFs

Covalent organic frameworks (COFs) with a pore size beyond 5 nm are still rarely seen in this emerging field. Besides obvious complications like the elaborated synthesis of large linkers with sufficient solubility, more subtle challenges regarding large-pore COF synthesis, including pore occlusion and collapse, prevail. Here we present two isoreticular series of large-pore imine COFs with pore sizes up to 5.8 nm and correlate the interlayer-interactions with the structure and thermal behavior of the COFs. By adjusting interlayer-interactionsthroughthe incorporation of methoxy groups acting as pore-directing “anchors”, different stacking modes can be accessed, resulting in modified stacking polytypes and, hence, effective pore sizes. A strong correlation between stacking energy towards highly ordered, nearly-eclipsed structures, higher structural integrity during thermal stress, and a novel, thermally induced phase transition of stacking modes in COFs was found, which sheds light on viable design strategies for increased structural control and stability in large-pore COFs