Development of a chlorhexidine delivery system based on dental reline acrylic resins

Acknowledgements The authors thank the Fundaç˜ao para a Ciˆencia e Tecnologia (FCT), Portugal for the financial support and Centro 2020 through the following projects: UIDB/04138/2020 and UIDP/04138/2020 (iMed. ULisboa), UIDB/05608/2020 and UIDP/05608/2020 (H&TRC), UIDP/ 04044/2020, PAMI - ROTEIRO/0328/2013 (N◦ 022158) and MATIS (CENTRO-01-0145-FEDER-000014 - 3362), L. Gonçalves Principal Researcher grant (CEECIND/03143/2017). Finally, the authors would like to thank VOCO GmbH (Cuxhaven, Germany) for the donation of the Ufi Gel Hard and Prof Alice Nogueira Alves for graphical advice.The high recurrence rate of common denture stomatitis after antifungal treatment is still concerning. This condition is caused by low patient compliance and incomplete local elimination of the main etiological factor — Candida albicans, often associated with other microorganisms, such as Streptococcus species. Impregnating denture materials with antimicrobials for local delivery is a strategy that can overcome the side effects and improve the efficacy of conventional treatments (topical and/or systemic). In this work, we describe the development of three hard autopolymerizing reline acrylic resins (Kooliner, Ufi Gel Hard, and Probase Cold) loaded with different percentages of chlorhexidine (CHX). The novel formulations were characterized based on their antimicrobial activity, mechanical, morphological and surface properties, in-vitro drug release profiles, and cytotoxicity. The addition of CHX in all resins did not change their chemical and mechanical structure. Among all the tested formulations, Probase Cold loaded with 5 wt% CHX showed the most promising results in terms of antimicrobial activity and lack of serious detrimental mechanical, morphological, surface, and biological properties.Fundação para a Ciência e Tecnologia (FCT), PortugalCentro 2020 through the following projects: UIDB/04138/2020 and UIDP/04138/2020 (iMed.ULisboa), UIDB/05608/2020 and UIDP/05608/2020 (H&TRC), UIDP/04044/2020, PAMI - ROTEIRO/0328/2013 (N° 022158)MATIS (CENTRO-01-0145-FEDER-000014 - 3362)Grant (CEECIND/03143/2017

Avaliação do desempenho do clone 3336 de Eucalyptus Urograndis na multiplicação e enraizamento in vitro.

Editores técnicos: Marcílio José Thomazini, Elenice Fritzsons, Patrícia Raquel Silva, Guilherme Schnell e Schuhli, Denise Jeton Cardoso, Luziane Franciscon. EVINCI. Resumos

Neonatal Brachial Plexus Palsy: Risk Factors and Its Prognostic Value

Introduction: Neonatal brachial plexus palsy affects 0.7 to 5.8 per 1,000 newborns and is characterised by upper limb paresis detected in the immediate neonatal period. Shoulder dystocia, instrumental delivery and foetal macrosomia are well-known risk factors. Most neonatal brachial plexus palsy evolve favourably, while 3%-27% of newborns have sequelae. Methods: A retrospective cross-sectional study was conducted to characterise neonatal brachial plexus palsy in the newborn population of a hospital with differentiated perinatal support and to assess the rela - tionship between the risk factors and lesion prognosis. The authors reviewed the newborn medical records referred to the physical medicine and rehabilitation clinic between January 2006 and December 2016. Results: During the study period, 137 cases of neo- natal brachial plexus palsy were identified in 36,833 births, which translate into an incidence of 3.7/1,000 live births. Foetal macrosomia was found in 41% and shoulder dystocia in 40%. According to the Narakas clas- sification, 58% were included in group I, 30% in group II, 9% in group III and 3% in group IV. The majority of patients were discharged without sequelae. Newborns with group II, III and IV lesions as well as macrosomic newborns were more likely to develop sequelae (p < 0.05). Shoulder dystocia and operative delivery did not present a statistically significant relationship with the prognosis of the lesion. Discussion: The incidence of neonatal brachial plexus palsy in this population was similar to is described in other series. The relationship between macrosomia and neonatal brachial plexus palsy with sequelae found may be of importance in the attempt to prevent this lesioninfo:eu-repo/semantics/publishedVersio

Elementary processes governing the evolution of road networks

Urbanisation is a fundamental phenomenon whose quantitative characterisation is still inadequate. We report here the empirical analysis of a unique data set regarding almost 200 years of evolution of the road network in a large area located north of Milan (Italy). We find that urbanisation is characterised by the homogenisation of cell shapes, and by the stability throughout time of high-centrality roads which constitute the backbone of the urban structure, confirming the importance of historical paths. We show quantitatively that the growth of the network is governed by two elementary processes: (i) `densification', corresponding to an increase in the local density of roads around existing urban centres and (ii) `exploration', whereby new roads trigger the spatial evolution of the urbanisation front. The empirical identification of such simple elementary mechanisms suggests the existence of general, simple properties of urbanisation and opens new directions for its modelling and quantitative description.Comment: 10 pages, 6 figure

Avaliação da organogênese in vitro do Clone 7 de Eucalyptus urograndis em diferentes meios de cultura.

Resumo

The Computer Science Ontology: A Large-Scale Taxonomy of Research Areas

Ontologies of research areas are important tools for characterising, exploring, and analysing the research landscape. Some fields of research are comprehensively described by large-scale taxonomies, e.g., MeSH in Biology and PhySH in Physics. Conversely, current Computer Science taxonomies are coarse-grained and tend to evolve slowly. For instance, the ACM classification scheme contains only about 2K research topics and the last version dates back to 2012. In this paper, we introduce the Computer Science Ontology (CSO), a large-scale, automatically generated ontology of research areas, which includes about 26K topics and 226K semantic relationships. It was created by applying the Klink-2 algorithm on a very large dataset of 16M scientific articles. CSO presents two main advantages over the alternatives: i) it includes a very large number of topics that do not appear in other classifications, and ii) it can be updated automatically by running Klink-2 on recent corpora of publications. CSO powers several tools adopted by the editorial team at Springer Nature and has been used to enable a variety of solutions, such as classifying research publications, detecting research communities, and predicting research trends. To facilitate the uptake of CSO we have developed the CSO Portal, a web application that enables users to download, explore, and provide granular feedback on CSO at different levels. Users can use the portal to rate topics and relationships, suggest missing relationships, and visualise sections of the ontology. The portal will support the publication of and access to regular new releases of CSO, with the aim of providing a comprehensive resource to the various communities engaged with scholarly data

Seleção de clone de Eucalyptus urophylla para uso como planta modelo em estudos de função gênica.

Editores técnicos: Marcílio José Thomazini, Elenice Fritzsons, Patrícia Raquel Silva, Guilherme Schnell e Schuhli, Denise Jeton Cardoso, Luziane Franciscon. EVINCI. Resumos