Internal structure and tectonic evolution of an underthrust tectonic m\ue9lange: the Sestola-Vidiciatico tectonic unit of the Northern Apennines, Italy

The Sestola-Vidiciatico Tectonic Unit (SVTU) in the Northern Apennines is an underthrust tectonic melange presently sandwiched between the Tuscan-Umbrian foredeep units and the overlying Ligurian/Subligurian thrust-nappe. The SVTU has been generated during the collision between the European and the Adria plates and now it separates the former oceanic accretionary wedge -Ligurian/Subligurian thrust nappe-from the underlying fold-and-thrust belt formed by Adria sedimentary units. The collision caused an eastward migrating foredeep basin and the overthrusting of the frontal part of the Ligurian/Subligurian thrust-nappe on the subducting Adria margin. Part of the inner lower-slope sediments of the migrating foredeep basin have been unconformably deposited on a frontal prism formed by material already accreted in the Ligurian/Subligurian prism gravitationally and tectonically reworked. The frontal prism and its sedimentary cover have been progressively dragged down along the plate boundary zone generating the SVTU. The lower-slope sediments have been incorporated in the melange as they were not completely lithified, and they show a long deformation history ranging from continuous and pervasive soft-sediment deformation to discontinuous brittle deformation concentrated along faults and mainly controlled by cycles of fluid pressure as testified by the presence of crack-and-seal texture and implosion breccia in the veins

949-97 The Prognostic Significance of Systolic and Diastolic Blood Pressure in the Elderly. Suggestions of a 10 Year Follow-up Study

Nowadays the studies evaluating the relationship between blood pressure and (total and cardiovascular) mortality in the elderly have provided conflicting results.Aim of the study was to evaluate the prognostic significance of systolic (SBP) and diastolic (DBP) blood pressure values in a cohort of 3858 elderly outpatients (mean age 72.7±4.9 years, range 65–96 years, 43.5% males) enrolled in the “Study on blood pressure in the elderly-SPAA” and followed up for 10 years.The initial assessment included two BP measurements in two visits. 90 subjects (2.3%) were lost to follow-up. There were 1546 (41%) deaths (TD), 698 from cardiovascular disease (CD). The Table shows the odds ratio (95% CI) for TD and CD according to baseline SBP and DBP (mmHg,*reference group) adjusted for main cardiovascular risk factors and diseases.SBP<140140-159160–179≥ 180TD1*1.1 (0.9–1.3)1.3 (0.0-1.6)1.5 (1.1-2.0)CD1*1.2 (0.9-1.6)1.4 (1.0-1.8)2.0 (1.4-3.0)DBP<9090-9495-104≥105TD1*1.1 (0.9-1.3)0.9 (0.7-1.1)1.2 (0.8-1.7)CD1*1.1(0.9-1.4)1.0 (0.8-1.4)1.2 (0.8-1.9)*reference groupIn our elderly population SBP was associated with total and cardiovascular mortality while DBP was not. A similar pattern was present in both sexes, in elderly aged less or more than 75 years and in subjects with or without pre-existing cardiovascular diseases.These data suggest that SBP should be emphasized more than DBP in the diagnosis and treatment of hypertension in the elderly

Prognostic Relevance of Multi-Antigenic Myeloma-Specific T-Cell Assay in Patients with Monoclonal Gammopathies

: Multiple Myeloma (MM) typically originates from underlying precursor conditions, known as Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple Myeloma (SMM). Validated risk factors, related to the main features of the clonal plasma cells, are employed in the current prognostic models to assess long-term probabilities of progression to MM. In addition, new prognostic immunologic parameters, measuring protective MM-specific T-cell responses, could help to identify patients with shorter time-to-progression. In this report, we described a novel Multi-antigenic Myeloma-specific (MaMs) T-cell assay, based on ELISpot technology, providing simultaneous evaluation of T-cell responses towards ten different MM-associated antigens. When performed during long-term follow-up (mean 28 months) of 33 patients with either MGUS or SMM, such deca-antigenic myeloma-specific immunoassay allowed to significantly distinguish between stable vs. progressive disease (p < 0.001), independently from the Mayo Clinic risk category. Here, we report the first clinical experience showing that a wide (multi-antigen), standardized (irrespective to patients' HLA), MM-specific T-cell assay may routinely be applied, as a promising prognostic tool, during the follow-up of MGUS/SMM patients. Larger studies are needed to improve the antigenic panel and further explore the prognostic value of MaMs test in the risk assessment of patients with monoclonal gammopathies

32.22 : La geologia del territorio di Guiglia e Zocca (Appennino modenese)

24 p., IV carte di tav., 1 carta geologica allegata

32.22 : La geologia del territorio di Guiglia e Zocca (Appennino modenese)

24 p., IV carte di tav., 1 carta geologica allegata

32.22 : La geologia del territorio di Guiglia e Zocca (Appennino modenese)

24 p., IV carte di tav., 1 carta geologica allegata