Fragile x syndrome and autism: from disease model to therapeutic targets

Autism is an umbrella diagnosis with several different etiologies. Fragile X syndrome (FXS), one of the first identified and leading causes of autism, has been modeled in mice using molecular genetic manipulation. These Fmr1 knockout mice have recently been used to identify a new putative therapeutic target, the metabotropic glutamate receptor 5 (mGluR5), for the treatment of FXS. Moreover, mGluR5 signaling cascades interact with a number of synaptic proteins, many of which have been implicated in autism, raising the possibility that therapeutic targets identified for FXS may have efficacy in treating multiple other causes of autism

Complexation of actinides by branched N-macrocycle DOTA

International audienceThis study shows the differences of behavior for the actinide (An) cations with their valence and its size in a givenseries versus the more or less hard donor atoms, such as oxygen and nitrogen. Plutonium(III) and americium(III)were chosen to represent the An(III) series, and for the An(+IV) series, uranium, neptunium and plutonium wereselected. The DOTA ligand, which is very well known for the cations in solution other than the actinides, was chosenbecause it has the two donor atoms: oxygen and nitrogen