9 research outputs found
Dirofilar铆ase pulmonar humana no Estado do Rio de Janeiro, Brasil: relato de um caso Human pulmonary dirofilariasis at Rio de Janeiro, Brazil: a case report
Relata-se caso de dirofilar铆ase pulmonar humana em paciente com 45 anos de idade, proveniente do Estado do Rio de Janeiro, Brasil. A radiografia tor谩cica evidenciou n贸dulo pulmonar solit谩rio localizado no l贸bulo inferior esquerdo, mimetizando neoplasia. Dirofilar铆ase pulmonar humana deveria ser investigada em n贸dulos pulmonares n茫o malignos e de etiologia n茫o conclusiva.<br>We report a case of human pulmonary dirofilariasis in a female patient 45-years-old, derived from Rio de Janeiro, Brazil. The chest radiologic finding consisted of single pulmonary nodule located on the left lower lobe that simulated lung tumor. Human pulmonary dirofilariasis might be investigated in nodules that are not malignants and require conclusive diagnosis
Human and Animal Dirofilariasis: the Emergence of a Zoonotic Mosaic
Summary: Dirofilariasis represents a zoonotic mosaic, which includes two main filarial species (Dirofilaria immitis and D. repens) that have adapted to canine, feline, and human hosts with distinct biological and clinical implications. At the same time, both D. immitis and D. repens are themselves hosts to symbiotic bacteria of the genus Wolbachia, the study of which has resulted in a profound shift in the understanding of filarial biology, the mechanisms of the pathologies that they produce in their hosts, and issues related to dirofilariasis treatment. Moreover, because dirofilariasis is a vector-borne transmitted disease, their distribution and infection rates have undergone significant modifications influenced by global climate change. Despite advances in our knowledge of D. immitis and D. repens and the pathologies that they inflict on different hosts, there are still many unknown aspects of dirofilariasis. This review is focused on human and animal dirofilariasis, including the basic morphology, biology, protein composition, and metabolism of Dirofilaria species; the climate and human behavioral factors that influence distribution dynamics; the disease pathology; the host-parasite relationship; the mechanisms involved in parasite survival; the immune response and pathogenesis; and the clinical management of human and animal infections