Charged Lepton Flavour Violating Radiative Decays ℓi→ℓj+γ\ell_i \to \ell_j + \gamma in See-Saw Models with A4A_4 Symmetry

The charged lepton flavour violating (LFV) radiative decays, $\mu\to e+\gamma$, $\tau\to \mu+\gamma$ and $\tau\to e +\gamma$ are investigated in a class of supersymmetric $A_4$ models with three heavy right-handed (RH) Majorana neutrinos, in which the lepton (neutrino) mixing is predicted to leading order (LO) to be tri-bimaximal. The light neutrino masses are generated via the type I see-saw mechanism. The analysis is done within the framework of the minimal supergravity (mSUGRA) scenario, which provides flavour universal boundary conditions at the scale of grand unification $M_X \approx 2 \times 10^{16}$ GeV. Detailed predictions for the rates of the three LFV decays are obtained in two explicit realisations of the $A_4$ models due to Altarelli and Feruglio and Altarelli and Meloni, respectively.Comment: Results unchanged, minor improvements made; version accepted for publication in JHE

The Regulatory Network of Natural Competence and Transformation of Vibrio cholerae

The human pathogen Vibrio cholerae is an aquatic bacterium frequently encountered in rivers, lakes, estuaries, and coastal regions. Within these environmental reservoirs, the bacterium is often found associated with zooplankton and more specifically with their chitinous exoskeleton. Upon growth on such chitinous surfaces, V. cholerae initiates a developmental program termed “natural competence for genetic transformation.” Natural competence for transformation is a mode of horizontal gene transfer in bacteria and contributes to the maintenance and evolution of bacterial genomes. In this study, we investigated competence gene expression within this organism at the single cell level. We provide evidence that under homogeneous inducing conditions the majority of the cells express competence genes. A more heterogeneous expression pattern was observable on chitin surfaces. We hypothesize that this was the case due to the heterogeneity around the chitin surface, which might vary extensively with respect to chitin degradation products and autoinducers; these molecules contribute to competence induction based on carbon catabolite repression and quorum-sensing pathways, respectively. Therefore, we investigated the contribution of these two signaling pathways to natural competence in detail using natural transformation assays, transcriptional reporter fusions, quantitative RT–PCR, and immunological detection of protein levels using Western blot analysis. The results illustrate that all tested competence genes are dependent on the transformation regulator TfoX. Furthermore, intracellular cAMP levels play a major role in natural transformation. Finally, we demonstrate that only a minority of genes involved in natural transformation are regulated in a quorum-sensing-dependent manner and that these genes determine the fate of the surrounding DNA. We conclude with a model of the regulatory circuit of chitin-induced natural competence in V. cholerae

The Forward Physics Facility at the High-Luminosity LHC

High energy collisions at the High-Luminosity Large Hadron Collider (LHC) produce a large number of particles along the beam collision axis, outside of the acceptance of existing LHC experiments. The proposed Forward Physics Facility (FPF), to be located several hundred meters from the ATLAS interaction point and shielded by concrete and rock, will host a suite of experiments to probe standard model (SM) processes and search for physics beyond the standard model (BSM). In this report, we review the status of the civil engineering plans and the experiments to explore the diverse physics signals that can be uniquely probed in the forward region. FPF experiments will be sensitive to a broad range of BSM physics through searches for new particle scattering or decay signatures and deviations from SM expectations in high statistics analyses with TeV neutrinos in this low-background environment. High statistics neutrino detection will also provide valuable data for fundamental topics in perturbative and non-perturbative QCD and in weak interactions. Experiments at the FPF will enable synergies between forward particle production at the LHC and astroparticle physics to be exploited. We report here on these physics topics, on infrastructure, detector, and simulation studies, and on future directions to realize the FPF's physics potential

INVESTIGATION OF LIPOFUSCIN IN CARDIAC MYOCYTES OF MICE TREATED WITH OXAMNIQUINE

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