Concentrations of remdesivir and GS-441524 in human milk from lactating individuals diagnosed with COVID-19

ImpactFindings from this study provide further reassuring evidence that infant exposure through human milk received from lactating individuals who require treatment with remdesivir is negligible

The impact of socioeconomic position on stage at diagnosis and survival in colorectal cancer patients in Switzerland

Studies outside of Switzerland have reported socioeconomic inequalities in colorectal cancer (CRC) stage at diagnosis and survival. Aim : To investigate the impact of socioeconomic position (SEP) and further demographic characteristics on colorectal cancer (CRC) stage at diagnosis on CRC-specific survival ; To investigate whether potential survival inequalities can be explained by differences in stage at diagnosis and/or sociodemographic factors

The Critical, Strategic Importance of Adaptive Optics-Assisted Ground-Based Telescopes for the Success of Future NASA Exoplanet Direct Imaging Missions

Ground-based telescopes coupled with adaptive optics (AO) have been playing a leading role in exoplanet direct imaging science and technological development for the past two decades and will continue to have an indispensable role for the next decade and beyond. Over the next decade, extreme AO systems on 8-10m telescopes will 1) mitigate risk for WFIRST-CGI by identifying numerous planets the mission can spectrally characterize, 2) validate performance requirements and motivate improvements to atmosphere models needed to unambiguously characterize solar system-analogues from space, and 3) mature novel technological innovations useful for space. Extremely Large Telescopes can deliver the first thermal infrared (10 $\mu m$) images of rocky planets around Sun-like stars and identify biomarkers. These data provide a future NASA direct imaging flagship mission (i.e. HabEx, LUVOIR) with numerous exo-Earth candidates and critical ancillary information to help clarify whether these planets are habitable.Comment: 5 pages, 3 figures; Astro2020 Decadal Survey submission; argues for strategic NASA support of ground-based exoplanet direct imaging science programs and tech development. arXiv admin note: substantial text overlap with arXiv:1803.0545

Habitable Exoplanet Observatory (HabEx)

The Habitable-Exoplanet Observatory (HabEx) is a candidate flagship mission being studied by NASA and the astrophysics community in preparation of the 2020 Decadal Survey. The first HabEx mission concept that has been studied is a large (~4m) diffraction-limited optical space telescope, providing unprecedented resolution and contrast in the optical, with extensions into the near ulttraviolet and near infrared domains. We report here on our team’s efforts in defining a scientifically compelling HabEx mission that is technologically executable, affordable within NASA’s expected budgetary envelope, and timely for the next decade. We also briefly discuss our plans to explore less ambitious, descoped missions relative to the primary mission architecture discussed here

The Critical, Strategic Importance of Adaptive Optics-Assisted Ground-Based Telescopes for the Success of Future NASA Exoplanet Direct Imaging Missions

Ground-based telescopes coupled with adaptive optics (AO) have been playing a leading role in exoplanet direct imaging science and technological development for the past two decades and will continue to have an indispensable role for the next decade and beyond. Over the next decade, extreme AO systems on 8-10m telescopes will 1) mitigate risk for WFIRST-CGI by identifying numerous planets the mission can spectrally characterize, 2) validate performance requirements and motivate improvements to atmosphere models needed to unambiguously characterize solar system-analogues from space, and 3) mature novel technological innovations useful for space. Extremely Large Telescopes can deliver the first thermal infrared (10 μm) images of rocky planets around Sun-like stars and identify biomarkers. These data provide a future NASA direct imaging flagship mission (i.e. HabEx, LUVOIR) with numerous exo-Earth candidates and critical ancillary information to help clarify whether these planets are habitable

The Habitable Exoplanet (HabEx) Imaging Mission: preliminary science drivers and technical requirements

HabEx is one of four candidate flagship missions being studied in detail by NASA, to be submitted for consideration to the 2020 Decadal Survey in Astronomy and Astrophysics for possible launch in the 2030s. It will be optimized for direct imaging and spectroscopy of potentially habitable exoplanets, and will also enable a wide range of general astrophysics science. HabEx aims to fully characterize planetary systems around nearby solar-type stars for the first time, including rocky planets, possible water worlds, gas giants, ice giants, and faint circumstellar debris disks. In particular, it will explore our nearest neighbors and search for signs of habitability and biosignatures in the atmospheres of rocky planets in the habitable zones of their parent stars. Such high spatial resolution, high contrast observations require a large (roughly greater than 3.5m), stable, and diffraction-limited optical space telescope. Such a telescope also opens up unique capabilities for studying the formation and evolution of stars and galaxies. We present some preliminary science objectives identified for HabEx by our Science and Technology Definition Team (STDT), together with a first look at the key challenges and design trades ahead

Habitable Exoplanet Observatory (HabEx)

The Habitable-Exoplanet Observatory (HabEx) is a candidate flagship mission being studied by NASA and the astrophysics community in preparation of the 2020 Decadal Survey. The first HabEx mission concept that has been studied is a large (~4m) diffraction-limited optical space telescope, providing unprecedented resolution and contrast in the optical, with extensions into the near ulttraviolet and near infrared domains. We report here on our team’s efforts in defining a scientifically compelling HabEx mission that is technologically executable, affordable within NASA’s expected budgetary envelope, and timely for the next decade. We also briefly discuss our plans to explore less ambitious, descoped missions relative to the primary mission architecture discussed here

The Habitable Exoplanet Observatory (HabEx) Mission Concept Study Final Report

The Habitable Exoplanet Observatory, or HabEx, has been designed to be the Great Observatory of the 2030s. For the first time in human history, technologies have matured sufficiently to enable an affordable space-based telescope mission capable of discovering and characterizing Earthlike planets orbiting nearby bright sunlike stars in order to search for signs of habitability and biosignatures. Such a mission can also be equipped with instrumentation that will enable broad and exciting general astrophysics and planetary science not possible from current or planned facilities. HabEx is a space telescope with unique imaging and multi-object spectroscopic capabilities at wavelengths ranging from ultraviolet (UV) to near-IR. These capabilities allow for a broad suite of compelling science that cuts across the entire NASA astrophysics portfolio. HabEx has three primary science goals: (1) Seek out nearby worlds and explore their habitability; (2) Map out nearby planetary systems and understand the diversity of the worlds they contain; (3) Enable new explorations of astrophysical systems from our own solar system to external galaxies by extending our reach in the UV through near-IR. This Great Observatory science will be selected through a competed GO program, and will account for about 50% of the HabEx primary mission. The preferred HabEx architecture is a 4m, monolithic, off-axis telescope that is diffraction-limited at 0.4 microns and is in an L2 orbit. HabEx employs two starlight suppression systems: a coronagraph and a starshade, each with their own dedicated instrument

The Habitable Exoplanet Observatory (HabEx) Mission Concept Study Final Report

The Habitable Exoplanet Observatory, or HabEx, has been designed to be the Great Observatory of the 2030s. For the first time in human history, technologies have matured sufficiently to enable an affordable space-based telescope mission capable of discovering and characterizing Earthlike planets orbiting nearby bright sunlike stars in order to search for signs of habitability and biosignatures. Such a mission can also be equipped with instrumentation that will enable broad and exciting general astrophysics and planetary science not possible from current or planned facilities. HabEx is a space telescope with unique imaging and multi-object spectroscopic capabilities at wavelengths ranging from ultraviolet (UV) to near-IR. These capabilities allow for a broad suite of compelling science that cuts across the entire NASA astrophysics portfolio. HabEx has three primary science goals: (1) Seek out nearby worlds and explore their habitability; (2) Map out nearby planetary systems and understand the diversity of the worlds they contain; (3) Enable new explorations of astrophysical systems from our own solar system to external galaxies by extending our reach in the UV through near-IR. This Great Observatory science will be selected through a competed GO program, and will account for about 50% of the HabEx primary mission. The preferred HabEx architecture is a 4m, monolithic, off-axis telescope that is diffraction-limited at 0.4 microns and is in an L2 orbit. HabEx employs two starlight suppression systems: a coronagraph and a starshade, each with their own dedicated instrument.Comment: Full report: 498 pages. Executive Summary: 14 pages. More information about HabEx can be found here: https://www.jpl.nasa.gov/habex