Gênero e sexualidade na formação docente: um mapeamento das pesquisas entre Norte e Nordeste

This article builds a mapping with the objective of analyzing theses and dissertations in gender, sexuality and teacher education defended in postgraduate programs in higher education institutions in the North and Northeast regions of Brazil. For that, theses and dissertations were mapped from 2006 to 2018 through a state-of-the-art type study. For this article, we bring the 22 works that involve teacher formation and, considering the objective of this study, we organized the discussion in two units of meaning: the first focused on the works that analyzes the conception of teachers in initial formation and the second, the works focused on the curriculum of this formation. In this perspective, some contributions, limits and possibilities of this academic production were observed.Este artículo construye un mapeo con el objetivo de analizar las tesis y disertaciones sobre género, sexualidad y educación docente defendidas en programas de posgrado en instituciones de educación superior en las regiones del Norte y Noreste de Brasil. Para eso, se mapearon tesis y disertaciones de 2006 a 2018 a través de un estudio de tipo de conocimiento. Para este artículo, presentamos los 22 trabajos que involucran la formación del profesorado y, teniendo en cuenta el objetivo de este estudio, organizamos la discusión en dos unidades de significado: el primero se centró en los trabajos que analizan la concepción de los profesores en la formación inicial y el segundo, los trabajos se centraron en el plan de estudios de esta capacitación. En esta perspectiva, se observaron algunas contribuciones, límites y posibilidades de esta producción académica.O presente artigo constrói um mapeamento com o objetivo de analisar as teses e dissertações em gênero, sexualidade e formação docente defendidas em programas de pós-graduação nas instituições de ensino superior das regiões Norte e Nordeste do Brasil. Para isso, foram mapeadas teses e dissertações no período de 2006 a 2018 por meio de um estudo do tipo estado da arte. Para este artigo, trouxemos os 22 trabalhos que envolvem formação de professoras/es e, considerando o objetivo deste estudo, organizamos a discussão em duas unidades de sentido: a primeira voltada para os trabalhos que fazem análise da concepção de professoras/es em formação inicial e a segunda os trabalhos voltados para o currículo desta formação. Nessa perspectiva, foram observadas algumas contribuições, limites e possibilidades dessa produção acadêmica

Crosstalk between genetic variability of adiponectin and leptin, glucose-insulin system and subclinical atherosclerosis in patients with newly diagnosed type 2 diabetes. The Verona Newly Diagnosed Type 2 Diabetes Study 14

Aim: To evaluate the relationship of genetic variability of adiponectin (ADIPOQ), leptin (LEP) and leptin receptor (LEPR) genes with glucose-insulin system and markers of subclinical atherosclerosis (ATS) in patients with newly diagnosed type 2 diabetes.Materials and methods: In 794 subjects we performed: 1) euglycemic hyperinsulinemic clamp to assess insulin sensitivity; 2) mathematical modelling of a 5h-OGTT to estimate ss-cell function; 3) resting ECG; 4) carotid artery and lower limb artery ecodoppler sonography to identify ATS; 5) genotyping of tag-SNPs within ADIPOQ, LEP and LEPR gene.Results: Regression analyses showed: 1) adiponectin levels were negatively associated with BMI, waist-to-hip ratio and triglycerides and positively with HDL and insulin sensitivity (p-all<0.03); 2) leptin levels were positively associated with BMI, HDL-cholesterol and plasma triglycerides and negatively with insulin sensitivity (p- all<0.001). Two SNPs (rs1501299 and rs2241767) within ADIPOQ gene were associated with circulating levels of adiponectin. The ADIPOQ-GAACA haplotype was associated with plasma adiponectin (p=0.034; ss=-0.24), ECG abnormalities ( p=0.012; OR=2.76), carotid ATS (p= 0.025; OR=2.00) and peripheral limb artery ATS ( p=0.032; OR=1.90). The LEP-CTA haplotype showed an association with ischemic ECG abnormalities (p=0.017; OR= 2.24). Finally, LEPR-GAACGG was associated with circulating leptin (p=0.005; ss=-0.31) and worst ss-cell function ( p=0.023; ss=-15.10). Omnibus haplotype analysis showed that ADIPOQ haplotypes were associated with levels of adiponectin and common carotid artery ATS, LEP with peripheral limb artery ATS, whereas LEPR haplotypes influenced circulating levels of leptin.Conclusions: Results of this study reinforce knowledge on adipokines' role in regulating glucose metabolism; in particular highlighted the potential atherogenic role of leptin and the anti atherogenic role of adiponectin

Prevalence and Risk Factors of Central Sensitization in Women with Endometriosis

Study objective: To assess prevalence of central sensitization (CS) and its association with demographic and clinical factors in patients with endometriosis. Design: Single-center, observational, cross-sectional study. Setting: Tertiary center. Patients: Consecutive patients with endometriosis referred to the center from January 15, 2022, to April 30, 2022. Interventions: For each enrolled patient, demographic and clinical data were collected, and the presence of CS was measured using the CS Inventory questionnaire (score ≥40). Measurements and main results: Primary study outcome was CS prevalence, and secondary study outcomes were the associations between demographic and clinical factors and CS. The 95% confidence intervals for CS prevalence were obtained with Bayesian-derived Jeffreys method, and the associations between CS and demographic and clinical factors were evaluated with the chi-square test and Fisher's exact test, where appropriate. The variables significantly associated with CS were then included in a multivariable logistic regression model. The significance level was set at .05 for all analyses. During the study period, 285 eligible women were enrolled. CS prevalence was 41.4% (95% confidence interval, 35.8-47.2). At univariable analysis, infertility, moderate to severe pain symptoms (except for dyschezia), altered bowel movements, posterolateral parametrium involvement, hormonal therapy failure (HTF), and most of central sensitivity syndromes were significantly associated with CS occurrence. Multivariable analysis only confirmed the significant association of CS with moderate to severe chronic pelvic pain, posterolateral parametrium involvement, HTF, migraine or tension-type headache, irritable bowel syndrome, and anxiety or panic attacks. Conclusion: CS has a high prevalence in patients with endometriosis, especially in those with moderate to severe chronic pelvic pain, posterolateral parametrium involvement, HTF, and 3 central sensitivity syndromes (i.e. migraine or tension-type headache, irritable bowel syndrome, anxiety or panic attacks). Given the association with HTF, identifying CS through CS Inventory might be useful to counsel the patient and to choose multimodal treatment

A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in 'real-world' services