Corneal Replication Is an Interferon Response-Independent Bottleneck for Virulence of Herpes Simplex Virus 1 in the Absence of Virion Host Shutoff

Herpes simplex viruses lacking the virion host shutoff function (Δvhs) are avirulent and hypersensitive to type I and type II interferon (IFN). In this study, we demonstrate that even in the absence of IFN responses in AG129 (IFN-αβγR−/−) mice, Δvhs remains highly attenuated via corneal infection but is fully virulent via intracranial infection. The data demonstrate that the interferon-independent inherent replication defect of Δvhs has a significant impact upon peripheral replication and neuroinvasion

QUELS MEDECINS POUR LES ENFANTS DE MEDECINS GENERALISTES ? A PROPOS D'UNE ENQUETE REALISEE AUPRES DE 186 MEDECINS GENERALISTES LIBERAUX DU RHONE

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Les soins pharmaceutiques en Amérique du Nord (mise en place, résultat et adaptabilité en France)

POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF

How to use Information Theory for Image Inpainting and Blind Spot Filling-in?

International audienceno abstrac