42 research outputs found
Corneal Replication Is an Interferon Response-Independent Bottleneck for Virulence of Herpes Simplex Virus 1 in the Absence of Virion Host Shutoff
Herpes simplex viruses lacking the virion host shutoff function (Δvhs) are avirulent and hypersensitive to type I and type II interferon (IFN). In this study, we demonstrate that even in the absence of IFN responses in AG129 (IFN-αβγR−/−) mice, Δvhs remains highly attenuated via corneal infection but is fully virulent via intracranial infection. The data demonstrate that the interferon-independent inherent replication defect of Δvhs has a significant impact upon peripheral replication and neuroinvasion
Roles of nucleic acid substrates and cofactors in the vhs protein activity of pseudorabies virus
QUELS MEDECINS POUR LES ENFANTS DE MEDECINS GENERALISTES ? A PROPOS D'UNE ENQUETE REALISEE AUPRES DE 186 MEDECINS GENERALISTES LIBERAUX DU RHONE
LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Les soins pharmaceutiques en Amérique du Nord (mise en place, résultat et adaptabilité en France)
POITIERS-BU Médecine pharmacie (861942103) / SudocSudocFranceF
How to use Information Theory for Image Inpainting and Blind Spot Filling-in?
International audienceno abstrac