Catalyzed Mizoroki–Heck Reaction or C–H activation

In the last few decades, research on the elaboration by palladium-catalytic processes of C-C bonds or the activation of C–H bonds has increased considerably. Yet there is still room for much improvement in terms of selectivity, or enantioselectivity, via the development of new ligands or the study of the catalytic effect of other metals to carry out the same chemical transformations. In addition, the attention paid to environmentally friendly methods in terms of the quantities of catalysts, ligands, and solvents is currently indispensable. The Mizoroki-Heck reaction is one of these important catalytic methods which generates C-C bonds in organic synthesis and is also possible by C-H activation. This book, titled “Catalyzed Mizoroki-Heck Reaction or C-H activation” focuses on new advances in the formation of C-C bonds or new C-H activation methods. It contains original research papers and short reviews on the synthesis of biologically active compounds using these catalytic processes, the identification of new catalysts, of new conditions allowing selectivity or enantioselectivity, the activity and stability of catalyst under turnover conditions, and all improvements in catalytic processes

The first catalytic direct C–H arylation on C2 and C3 of thiophene ring applied to thieno-pyridines, -pyrimidines and -pyrazines

Supplementary Materials: Supplementary materials are available online at: http://www.mdpi.com/2073-4344/ 8/4/137/s1.A practical one-pot procedure for the preparation of diverse thieno[3,2-d]pyrimidines is reported here for the first time. This two-step process via C–H activation in position C-2 of thiophene led to the development of an improved methodology for the synthesis of numerous compounds. This new methodology is an efficient alternative to the conventional methods currently applied. The C–H activation of the thiophene C-3 position was also achieved and can be selective. The optimized conditions can also be applied to thienopyridines and thienopyrazines.info:eu-repo/semantics/publishedVersio

Catalyzed Mizoroki-Heck Reaction or C-H Activation

In the last few decade, research conducted on the development by catalytic processes of C-C bonds formation on the one hand and on the other hand on the activation of C-H bonds has grown considerably [...