{presence} an interactive dance event

{presence} was an interactive dance event that performed at the Hamilton Gardens as part of the Hamilton Fringe Festival 2015 A collaborative partnership between Joe Citizen and Black Sheep Productions, with Kent Macpherson, Megan Berry, Rob Thorne, Aaron Chesham (ACLX), and Jaimee Cruse. {presence} was an experiment that sought to celebrate women and womanhood through a live interactive performance. It combined contemporary dance, taonga pūoro, contemporary music, body-mediated interactive lighting components, and wireless sensor networks

Anti-Persistence on Persistent Storage: History-Independent Sparse Tables and Dictionaries

International audienceWe present history-independent alternatives to a B-tree, the primary indexing data structure used in databases. A data structure is history independent (HI) if it is impossible to deduce any information by examining the bit representation of the data structure that is not already available through the API. We show how to build a history-independent cache-oblivious B-tree and a history-independent external-memory skip list. One of the main contributions is a data structure we build on the way—a history-independent packed-memory array (PMA). The PMA supports efficient range queries, one of the most important operations for answering database queries. Our HI PMA matches the asymptotic bounds of prior non-HI packed-memory arrays and sparse tables. Specifically, a PMA maintains a dynamic set of elements in sorted order in a linear-sized array. Inserts and deletes take an amortized O(log^2 N) element moves with high probability. Simple experiments with our implementation of HI PMAs corroborate our theoretical analysis. Comparisons to regular PMAs give preliminary indications that the practical cost of adding history-independence is not too large. Our HI cache-oblivious B-tree bounds match those of prior non-* HI cache-oblivious B-trees. Searches take O(log_B N) I/Os; inserts and deletes take O((log^2 N)/B + log_B N) amortized I/Os with high probability; and range queries returning k elements take O(log_B N + k/B) I/Os. Our HI external-memory skip list achieves optimal bounds with high probability, analogous to in-memory skip lists: O(log_B N) I/Os for point queries and amortized O(log_B N) I/Os for in-serts/deletes. Range queries returning k elements run in O(log_B N + k/B) I/Os. In contrast, the best possible high-probability bounds for inserting into the folklore B-skip list, which promotes elements with probability 1/B, is just Θ(log N) I/Os. This is no better than the bounds one gets from running an in-memory skip list in external memory

Changes in Kelp and Other Seaweeds Following Elwha Dam Removal

Kelps are ecologically important seaweeds that dominated the nearshore vegetation community prior to dam removal on the Elwha River. Dam removal is expected to trigger a shift from kelps to vegetation types that are characteristic of soft-sediment communities through restoring natural sediment supply. This study is investigating how nearshore vegetation responds to restoration of the natural sediment regime, both initially when large amounts of sediment entrained in the reservoirs are released and over longer time periods. We assessed vegetation at multiple spatial scales using three approaches. First, we measured floating kelp canopy area using aerial photography. Second, we assessed the abundance of understory kelp and seagrasses with towed videography along 50 km of shoreline. Third, scuba divers recorded density of kelp species and other seaweeds along 10 km of shoreline bracketing the river mouth. Results show profound changes in vegetation and a strong gradient in magnitude of impact related to distance from the river mouth. Floating kelp canopy area decreased 74% in the Elwha Drift Cell in the first year following project initiation (year 1), with lower magnitude losses throughout the Strait of Juan de Fuca. Area of prostrate kelps decreased by 45% (400 ha) and of stipitate kelps by 30% (130 ha) in the Elwha Drift Cell in year 1. Mean kelp density near the river mouth decreased 77% in year 1 and 95% in year 2. While all 10 kelp species declined, annuals were more impacted than perennials. In contrast to the general decline, juveniles of several kelp species appeared in late August of year 2, a substantial delay compared to typical spring timing of juvenile growth. What caused the large kelp losses and apparent delay of juvenile growth? Likely candidates include light reduction from the river plume and scour, burial or settlement inhibition from deposition. These candidates will be explored using physical data from the multidisciplinary research effort

A family history of breast cancer will not predict female early onset breast cancer in a population-based setting

ABSTRACT: BACKGROUND: An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting. METHODS: An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer. RESULTS: The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12-10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83-5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33-9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30. CONCLUSION: Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age

Osteocalcin binds tightly to the γ-glutamylcarboxylase at a site distinct from that of the other known vitamin K-dependent proteins

Vitamin K-dependent proteins contain a propeptide that is required for recognition by the enzyme gamma-glutamylcarboxylase. Substrates used in vitro for carboxylation studies lacking a prosequence are characterized by Km values in the millimolar range, whereas the Km for peptides containing a prosequence is three or four orders of magnitude smaller. Here we report that descarboxy-osteocalcin is an exception in this respect. With descarboxy-osteocalcin in purified propeptide-free recombinant carboxylase, the Km was 1.8 microM. Furthermore, osteocalcin was an inhibitor of descarboxy-osteocalcin carboxylation with a Ki of 76 microM. In contrast with the other vitamin K-dependent proteins, free propeptides do not inhibit descarboxy-osteocalcin carboxylation. Moreover, propeptide-containing substrates were inhibited neither by osteocalcin nor by its propeptide. From our studies we conclude that descarboxy-osteocalcin must have an internal recognition sequence that binds to gamma-glutamylcarboxylase at a site different from the propeptide-recognition site

FireGrid: Integrated emergency response and fire safety engineering for the future built environment

FireGrid is researching the development and integration of modelling, sensors, Grid, HPC, and C/C technologies. It will stimulate further research, in new safety systems and strategies, in new sensor technologies, in improved modelling techniques and in Grid technologies and operation. By integrating previously uncoupled tools, FireGrid will allow true performance-based design for the built environment. It will introduce a new emergency response paradigm, using scenarios planned and stored in advance in conjunction with super-real-time simulation. Deployment of FireGrid will reduce costs and save lives

Combining policy analyses, exploratory scenarios, and integrated modelling to assess land use policy options

Scenario-based approaches provide decision makers with accessible storylines of potential future changes. The parameterisation of such storylines as input variables for integrated assessment models allows using models as a test bed for assessing the effects of alternative land use policy options in different scenarios. However, the potential of this kind of policy-screening analysis can be further improved by assessing the institutional compatibility of the policy options under review. The aim of this paper is to explore the added value of combining institutions-oriented policy analyses with scenario-modelling approaches for improved assessments of EU land use policy options. We describe an expert-based, stepwise process to combine four scenario storylines and two integrated assessment model approaches (CLIMSAVE & IMAGE-GLOBIO) with a procedure for institutional compatibility assessment. Among the subsidies we assessed were those for technology-driven intensification of agricultural production, which would contribute to decreasing demand for cropland across a range of scenarios. In regionalised policy designs, they also contribute to ecological effectiveness, and higher costs of governing. Subsidies to promote biomass production can have negative effects on ecosystems including land conversion, conversion of grassland into cropland as well as conversion of natural forests into managed forests. These effects can to some extent be mitigated by careful policy design which considers the institutional context and features cross-sectoral coordination. An integrated Ecosystem Services Framework policy could accommodate regionalised policy designs and cross-sectoral coordination, however, it can operate only under specific circumstances and needs particular efforts. Rural development approaches are another alternative which feature expansion of cropland by means of a large-scale, bottom-up transformation based on voluntary changes in behaviour, flexibility, participation, and local and regional collaboration. Apart from a vast number of interdisciplinary lessons learned, we also gained insights from the science-policy interface. A weak EU appeared as a plausible scenario from a scientific perspective, given the current political environment. However, it appreaded to be unacceptable at EU level policy making. We decided to maintain scientific independence and looked at policy options also in the context of a weak EU yielding environmentally beneficial opportunities for regional decision making at the expense of relevance of our scenarios to EU level policy makers