74 research outputs found
Satellite dna content of chromatin fractions isolated from eco r1-digested mouse liver nuclei.
A cis-active regulatory gene in the mouse: direct demonstration of cis-active control of the rate of enzyme subunit synthesis.
Enhanced expression of alkaline phosphatase in hybrids between neuroblastoma and embryonal carcinoma.
Regulation of mitochondrial malic enzyme synthesis in mouse brain.
In a previous study [Bernstine, E.G. (1979) J. Biol. Chem. 254, 83-87] it was shown that inbred strains of mice fall into two classes based on the specific activity of mitochondrial malic enzyme [L-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating), EC 1.1.1.40] in brain. In this report we demonstrate differences between high- and low-activity strains in the development of enzyme activity levels in adult mice and show that the rate of enzyme synthesis quantitatively accounts for the inherited level of the brain enzyme. Genetic analysis has established that the locus controlling the amount of enzyme in brain (Mdr-1) is located on chromosome 7. Its linkage to Hbb and c places it in the same region of the chromosome as Mod-2, the structural gene for mitochondrial malic enzyme. By making use of deletions and a duplication that include Mod-2, evidence for cis action of Mdr-1 was obtained
Retroviral integration sites in transgenic Mov mice frequently map in the vicinity of transcribed DNA regions
Effect of gene dosage on expression of mitochondrial malic enzyme activity in the mouse.
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