Navigated cup implantation in hip arthroplasty: A meta-analysis

Background and purpose Many studies have suggested that navigation-based implantation can improve cup positioning in total hip arthroplasty (THA). We conducted a systematic review and meta-analysis to compile the best available evidence, and to overcome potential shortcomings because of small sample sizes in individual studies

Struktur, Stabilität und antioxidative Wirkung von Polyhydroxyphenolen aus Spinat

Spinat enthält neben beta-Carotin, Vitamin C und E Phenolcarbonsäuren und Flavonoide mit antioxidativer Wirkung, die mit modernen Analysenmethoden wie NMR, GC-MS und LC-MS/MS untersucht wurden. Bei den Phenolcarbonsäuren handelt es sich um die cis- und trans-Isomere der p-Cumarsäure und Ferulasäure. Sie liegen als Glykoside vor oder sind mit organischen Säuren verestert. Hauptkomponente ist die 2-O-p-Cumaroyl-3-O-acetyl-meso-weinsäure. Bei den Flavonolglykosiden konnten zwölf Verbindungen identifiziert werden. Es sind jeweils Verbindungen der Aglykone Patuletin und Spinacetin mit Glucose und Apiose, die wiederum mit Phenolcarbonsäuren verestert sein können. Bei den Flavonolglucuroniden konnten die vier Aglykone Spinatosid, Jaceidin, 3´,4',5-Trihydroxy-3-methoxy-6:7-methylendioxy-flavon und 4',5-Dihydroxy-3,3´-dimethoxy-6:7-methylendioxy-flavon identifiziert werden. Sie sind jeweils in 4'-Position durch Glucuronsäure substituiert. Neben der Identifizierung wurde der Verlust der im Spinat vorkommenden Antioxidantien während des Produktionsprozesses und deren antioxidativen Eigenschaften untersucht

Measurement uncertainty for persistent organic pollutants by isotope dilution mass spectrometry

European working group on Measurement uncertainty for POP

Microbial adhesion on novel yttria-stabilized tetragonal zirconia (Y-TZP) implant surfaces with nitrogen-doped hydrogenated amorphous carbon (a-C:H:N) coatings

cited By 2International audienceObjectives: Biomaterial surfaces are at high risk for initial microbial colonization, persistence, and concomitant infection. The rationale of this study was to assess the initial adhesion on novel implant surfaces of Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans upon incubation. Materials and methods: The tested samples were 3 mol% yttria-stabilized tetragonal zirconia polycrystal (3Y-TZP) samples with nitrogen-doped hydrogenated amorphous carbon (a-C:H:N) coating (A) and 3Y-TZP samples coated with ceria-stabilized zirconia-based (Ce-TZP) composite and a-C:H:N (B). Uncoated 3Y-TZP samples (C) and bovine enamel slabs (BES) served as controls. Once the surface was characterized, the adherent microorganisms were quantified by estimating the colony-forming units (CFUs). Microbial vitality was assessed by live/dead staining, and microbial-biomaterial surface topography was visualized by scanning electron microscopy (SEM). Results: Overall, A and B presented the lowest CFU values for all microorganisms, while C sheltered significantly less E. faecalis, P. aeruginosa, and C. albicans than BES. Compared to the controls, B demonstrated the lowest vitality values for E. coli (54.12 %) and C. albicans (67.99 %). Interestingly, A (29.24 %) exhibited higher eradication rates for S. aureus than B (13.95 %). Conclusions: Within the limitations of this study, a-C:H:N-coated 3Y-TZP surfaces tended to harbor less initially adherent microorganisms and selectively interfered with their vitality. Clinical relevance: This could enable further investigation of the new multi-functional zirconia surfaces to confirm their favorable antimicrobial properties in vivo. © 2015, Springer-Verlag Berlin Heidelberg

CCDC 246960: Experimental Crystal Structure Determination

Related Article: H.Bernsmann, M.van den Berg, R.Hoen, A.J.Minnaard, G.Mehler, M.T.Reetz, J.G.De Vries, B.L.Feringa|2005|J.Org.Chem.|70|943|doi:10.1021/jo048374o,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.