Small business and entrepreneurship in Nebraska

How does small business and entrepreneurship in Nebraska compare to its counterparts in other regions of the U.S.? What determines the rates of business formation in a community? What are the significant characteristics of Nebraska small businesses

Perceptions of cause-related marketing tactics

Study of small business owners in Nebraska reveals reluctance to make judgements about tactics intended to manipulate customers and more certainty about genuine charitable actions

The Canadian Army Medical Corps affair of 1916 and Surgeon General Guy Carleton Jones

The rapid expansion of military medical service in the First World War, successfully completed under the direction of Surgeon General Guy Carleton Jones, remains an extraordinary achievement in Canada’s history. In 1916, a conflict of personalities threatened confidence in the service. Eventually Prime Minister Sir Robert Borden’s intervention restored the status quo, but the affair eclipsed Jones’s outstanding career

Functional classes of bronchial mucosa genes that are differentially expressed in asthma

BACKGROUND: Asthma pathogenesis and susceptibility involves a complex interplay between genetic and environmental factors. Their interaction modulates the airway inflammation and remodelling processes that are present even in mild asthma and governs the appearance and severity of symptoms of airway hyperresponsiveness. While asthma is felt to develop as the result of interaction among many different genes and signalling pathways, only a few genes have been linked to an increased risk of developing this condition. RESULTS: We report the results of expression microarray studies using tissue obtained from bronchial biopsies of healthy controls and of subjects with allergic asthma, both before and following inhaled corticotherapy. We identified 79 genes that show significant differences in expression (following Bonferroni cutoff using p < 6.6 × 10(-6 )to correct for multiple testing) in asthmatics compared to controls at significance levels. These included 21 genes previously implicated in asthma, such as NOS2A and GPX3, as well as new potential candidates, such as ALOX15, CTSC and CX3CR1. The expression levels of one third of these transcripts were partially or completely corrected following inhaled corticosteroid therapy. CONCLUSION: The study shows that bronchial biopsies obtained from healthy and asthmatic subjects display distinct expression profiles. These differences provide a global view of physiopathologic processes active in the asthmatic lung and may provide invaluable help to clarify the natural history of asthma

Estimation of normalized point-source sensitivity of segment surface specifications for extremely large telescopes

We present a method which estimates the normalized point-source sensitivity (PSSN) of a segmented telescope when only information from a single segment surface is known. The estimation principle is based on a statistical approach with an assumption that all segment surfaces have the same power spectral density (PSD) as the given segment surface. As presented in this paper, the PSSN based on this statistical approach represents a worst-case scenario among statistical random realizations of telescopes when all segment surfaces have the same PSD. Therefore, this method, which we call the vendor table, is expected to be useful for individual segment specification such as the segment polishing specification. The specification based on the vendor table can be directly related to a science metric such as PSSN and provides the mirror vendors significant flexibility by specifying a single overall PSSN value for them to meet. We build a vendor table for the Thirty Meter Telescope (TMT) and test it using multiple mirror samples from various mirror vendors to prove its practical utility. Accordingly, TMT has a plan to adopt this vendor table for its M1 segment final mirror polishing requirement

Social attention: a possible early indicator of efficacy in autism clinical trials

For decades, researchers have sought to clarify the nature of the social communication impairments in autism, highlighting impaired or atypical 'social attention' as a key measurable construct that helps to define the core impairment of social communication. In this paper, we provide an overview of research on social attention impairments in autism and their relation to deficiencies in neural circuitry related to social reward. We offer a framework for considering social attention as a potential moderator or mediator of response to early behavioral intervention, and as an early indicator of efficacy of behavioral and/or pharmacological treatments aimed at addressing the social impairments in autism

Science results from the imaging Fourier transform spectrometer SpIOMM

SpIOMM is an imaging Fourier transform spectrometer designed to obtain the visible range (350 to 850 nm) spectrum of every light source in a circular field of view of 12 arcminutes in diameter. It is attached to the 1.6-m telescope of the Observatoire du Mont Megantic in southern Quebec. We present here some results of three successful observing runs in 2007, which highlight SpIOMMs capabilities to map emission line objects over a very wide field of view and a broad spectral range. In particular, we discuss data cubes from the planetary nebula M27, the supernova remnants NGC 6992 and M1, the barred spiral galaxy NGC7479, as well as Stephans quintet, an interacting group of galaxies.Comment: 10 pages, 7 figures, to appear in "Ground-based and Airborne Instrumentation for Astronomy II", SPIE conference, Marseille, 23-28 June 200

The Irrigation Efficiency Trap: Rational Farm-Scale Decisions Can Lead to Poor Hydrologic Outcomes at the Basin Scale

Agricultural irrigation practices have changed through time as technology has enabled more efficient conveyance and application. In some agricultural regions, irrigation can contribute to incidental aquifer recharge important for groundwater return flows to streams. The Henrys Fork Snake River, Idaho (United States) overlies a portion of the Eastern Snake Plain Aquifer, where irrigated agriculture has occurred for over a century. Using irrigator interviews, aerial and satellite imagery, and statistical streamflow analysis, we document the impact of farm-scale decisions on basin-scale hydrology. Motivated to improve economic efficiency, irrigators began converting from surface to center-pivot sprinkler irrigation in the 1950s, with rapid adoption of center-pivot sprinklers through 2000. Between 1978–2000 and 2001–2022, annual surface-water diversion decreased by 311 Mm3 (23%) and annual return flow to the river decreased by 299 Mm3 over the same period. Some reaches that gained water during 1978–2000 lost water to the aquifer during the later period. We use an interdisciplinary approach to demonstrate how individual farm-scale improvements in irrigation efficiency can cumulatively affect hydrology at the landscape scale and alter groundwater-surface water relationships. Return flows are an important part of basin hydrology in irrigated landscapes and we discuss how managed and incidental aquifer recharge can be implemented to recover return flows to rivers

Meta-omics-aided isolation of an elusive anaerobic arsenic-methylating soil bacterium.

Soil microbiomes harbour unparalleled functional and phylogenetic diversity. However, extracting isolates with a targeted function from complex microbiomes is not straightforward, particularly if the associated phenotype does not lend itself to high-throughput screening. Here, we tackle the methylation of arsenic (As) in anoxic soils. As methylation was proposed to be catalysed by sulfate-reducing bacteria. However, to date, there are no available anaerobic isolates capable of As methylation, whether sulfate-reducing or otherwise. The isolation of such a microorganism has been thwarted by the fact that the anaerobic bacteria harbouring a functional arsenite S-adenosylmethionine methyltransferase (ArsM) tested to date did not methylate As in pure culture. Additionally, fortuitous As methylation can result from the release of non-specific methyltransferases upon lysis. Thus, we combined metagenomics, metatranscriptomics, and metaproteomics to identify the microorganisms actively methylating As in anoxic soil-derived microbial cultures. Based on the metagenome-assembled genomes of microorganisms expressing ArsM, we isolated Paraclostridium sp. strain EML, which was confirmed to actively methylate As anaerobically. This work is an example of the application of meta-omics to the isolation of elusive microorganisms