An Evaluative Framework of Legal Aid Models

The purpose of this Article is to place the systems for legal service to the poor in the developed countries of the world within an evaluative perspective that may be useful to planners of such systems in developing countries. Part I presents one exposition of the process of national development, with particular emphasis on the role of law and lawyers. Part II describes the major legal service systems used in the West. In Part III, some observations are offered about the relationship between a country’s development goals and its choice of a legal service program or system

Revisiting Hafemeister’s ‘Science and Society’ Tests

We revisit a series of papers on science and society issues by David Hafemeister in the 1970s and 1980s. The emphasis in the present work is on world oil production limits and some consequences of various possible scenarios for the near future. Some of the data and scenarios used by Hafemeister are updated for U.S. oil production in the past two decades and extended to an analysis of a peak in world oil production in the future. We discuss some simple scenarios for future energy use patterns and look at the consequence of these scenarios as world oil production begins to decline. We also provide a list of resources for critical investigations of natural resource extraction and depletion patterns

Direct measure of the exciton formation in quantum wells from time resolved interband luminescence

We present the results of a detailed time resolved luminescence study carried out on a very high quality InGaAs quantum well sample where the contributions at the energy of the exciton and at the band edge can be clearly separated. We perform this experiment with a spectral resolution and a sensitivity of the set-up allowing to keep the observation of these two separate contributions over a broad range of times and densities. This allows us to directly evidence the exciton formation time, which depends on the density as expected from theory. We also evidence the dominant contribution of a minority of excitons to the luminescence signal, and the absence of thermodynamical equilibrium at low densities

Absolute quantitation of DNA methylation of 28 candidate genes in prostate cancer using pyrosequencing

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Aberrant DNA methylation plays a pivotal role in carcinogenesis and its mapping is likely to provide biomarkers for improved diagnostic and risk assessment in prostate cancer (PCa). We quantified and compared absolute methylation levels among 28 candidate genes in 48 PCa and 29 benign prostate hyperplasia (BPH) samples using the pyrosequencing (PSQ) method to identify genes with diagnostic and prognostic potential. RARB, HIN1, BCL2, GSTP1, CCND2, EGFR5, APC, RASSF1A, MDR1, NKX2-5, CDH13, DPYS, PTGS2, EDNRB, MAL, PDLIM4, HLAa, ESR1 and TIG1 were highly methylated in PCa compared to BPH (p < 0.001), while SERPINB5, CDH1, TWIST1, DAPK1, THRB, MCAM, SLIT2, CDKN2a and SFN were not. RARB methylation above 21% completely distinguished PCa from BPH. Separation based on methylation level of SFN, SLIT2 and SERPINB5 distinguished low and high Gleason score cancers, e.g. SFN and SERPINB5 together correctly classified 81% and 77% of high and low Gleason score cancers respectively. Several genes including CDH1 previously reported as methylation markers in PCa were not confirmed in our study. Increasing age was positively associated with gene methylation (p < 0.0001). Accurate quantitative measurement of gene methylation in PCa appears promising and further validation of genes like RARB, HIN1, BCL2, APC and GSTP1 is warranted for diagnostic potential and SFN, SLIT2 and SERPINB5 for prognostic potential