Residual tumor tissue detected by [¹⁸F]FET-PET—Follow-up.

<p> Patient #18. <b>A,B:</b> sagittal slices. <b>C,D:</b> axial slices. <b>A:</b> Pre-operative PET showing focal uptake in the right parietal lobe. <b>B:</b> Suspicious uptake in the cranial border of the resection cavity 48h and <b>C:</b> 4 months after resection, consistent with vital tumor. <b>D:</b> Corresponding MRI 4 months after resection corroborating the PET finding.</p

Comparison of all 3 modalities: PET, MRI and intraoperative findings (IF).

<p><b>IR</b> = incomplete resection; <b>CR</b> = complete resection.</p><p>Comparison of all 3 modalities: PET, MRI and intraoperative findings (IF).</p

Example of a complete resection.

<p>Patient #2. Transaxial slices. <b>A:</b> Intense focal [¹⁸F]FET uptake in the right temporal lobe. <b>B:</b> MRI (FLAIR-sequence) with diffuse hyperintensity in the same region. <b>C:</b> [¹⁸F]FET-PET (48h after resection) and <b>D:</b> MRI (24 h after resection, FLAIR) with no signs of residual tumor tissue.</p

Patients´ characteristics.

<p>Patients´ characteristics.</p

Residual glioma tissue detected by [¹⁸F]FET-PET–Re-resection.

<p>Patient #7. Transaxial slices of [¹⁸F]FET-PET (upper row) and corresponding contrast-enhanced T1-weighted MRI. <b>A:</b> Pre-operative PET with intense focal uptake in the left frontal lobe consistent with a lesion on MRI. <b>B:</b> Early postoperative PET with focal uptake at the cranio-medial border of the resection cavity, leading to re-resection; MRI displaying unspecific changes. <b>C:</b> Early postoperative PET after re-resection showing the resection cavity with no focal uptake in the border region, consistent with complete resection (confirmed by MRI). Histopathology confirmed glioblastoma.</p