Results of the whole-brain analysis comparing regional homogeneity (ReHo) as derived from resting-state acquisitions during near-threshold vs. no-tone condition.

<p>Results of the whole-brain analysis comparing regional homogeneity (ReHo) as derived from resting-state acquisitions during near-threshold vs. no-tone condition.</p

Schematic drawing of the experimental setup.

<p>Schematic drawing of the experimental setup.</p

Results of whole-brain contrast regional homogeneity (ReHo) maps acquired during near-threshold vs. no-tone condition.

<p>Higher local connectivity in: (A) Right superior temporal gyrus (rSTG) in a sagittal (left), coronal (middle) and transversal (right) slice, as well as in (B) Anterior cingulate cortex (ACC) (p < 0.001, cluster-size corrected by means of Monte Carlo simulation, k > 22). (C) Higher local connectivity in right amygdala (rAmyg) when using a more lenient cluster threshold of k > 10.</p

ReHo results.

<p>Statistical analysis of beta values extracted from the respective clusters observed in the whole-brain contrasts.</p

Acoustical characterization of 14 participants according to hearing threshold and categorical loudness scaling measurements for an IS-pure tone at 12 Hz.

<p>Acoustical characterization of 14 participants according to hearing threshold and categorical loudness scaling measurements for an IS-pure tone at 12 Hz.</p

Significant condition differences in resting state fMRI of the ICA.

<p>Significant condition differences in resting state fMRI of the ICA.</p

Box plot showing regional homogeneity (ReHo) differences across conditions.

<p>Box plot showing regional homogeneity (ReHo) differences across conditions.</p

Statistical data for GEE and combined model GEE (NAWM = normal-appearing white matter, VC = visual cortex).

<p>Statistical data for GEE and combined model GEE (NAWM = normal-appearing white matter, VC = visual cortex).</p

Correlation of RNFLT with BPF and ¹H-MRS parameters.

<p>a) Depicted is the average RNFLT, every symbol representing a single eye examined together with the corresponding BPF values. The symbols represent the patient's previous history of optic neuritis (open circles – no previous optic neuritis, grey squares - unilateral optic neuritis, black triangles – bilateral optic neuritis) A linear correlation function was calculated by a Generalised Linear Model to account for intra-individual inter-eye relationships (p = 0.001). b) Mean BPF was calculated for three groups that were defined based on their previous history of optic neuritis (white bar– no previous optic neuritis, grey bar - unilateral optic neuritis, black bar – bilateral optic neuritis). The (-) symbol indicates a trend, but a missing significant correlation of group differences as calculated by ANOVA (p = 0.055). Error bars represent 2× standard error of the mean (SEM). c) RNFLT averages are shown in relation to corresponding NAA concentrations in the visual cortex (VC). The symbols are coded as in a). The correlation is significant (p = 0.047). d) Mean visual cortex voxel (VC) NAA and the significance of group differences was calculated for optic neuritis groups as in b). The asterisk indicates statistically significant (p = 0.046) group differences. Error bars represent 2× standard error of the mean (SEM). e) RNFLT averages are shown in relation to corresponding NAA concentrations in normal-appearing white matter (NAWM). The symbols are coded as in a). No significant correlation was found (p = 0.531). f) Mean NAA in normal-appearing white matter (NAWM) and the significance of group differences was calculated for optic neuritis groups as in b) (p = 0.429). Error bars represent 2× standard error of the mean (SEM).</p

Summary of demographic data, mean RNFLT, mean BPF, mean normal-appearing white matter (NAWM) NAA concentrations, mean visual cortex (VC) NAA concentrations.

<p>(NON/NON – no previous optic neuritis, NON/ON – previous unilateral optic neuritis, ON/ON - previous bilateral optic neuritis).</p