CD69⁺ antigen specific T cells after aP booster vaccination.

<p>Surface markers on T-lymphocytes were measured after 48 h of stimulation with pertussis antigens (PT, FHA, PRN, FIM), without antigen stimulation (CO), or with diphtheria/tetanus (DT) antigen stimulation. Immunophenotyping was performed prior to (pre) and 28–36 days after (post) aP booster vaccination. The percentages of CD8⁺CD69⁺<b>(a)</b> and CD4⁺CD69⁺<b>(b)</b> lymphocytes within the total lymphocyte population are shown for all participants. To show outliers, the y-axis was divided into two scales (tilde). Scatter blot; horizontal lines indicate the median value. * significant increase/decrease after vaccination (Wilcoxon-test; p<0.05). ** highly significant increase/decrease after vaccination (Wilcoxon-test; p<0.01).</p

IFN-γ and TNF-α secretion after aP booster vaccination.

<p>Cytokine secretion in post-booster culture supernatants was measured after 48 h of stimulation with PT by cytometric bead arrays. To show outliers the y-axis was divided into two scales (tilde). Horizontal lines indicate the median value.</p

Distribution of participants and of Th1/Th2 cytokine secretion.

<p>The distribution of all participants and of the participants with detectable Th1/Th2 cytokine secretion within the three vaccination groups is shown. There was no Th2 cytokine secretion detectable in participants with exclusive wcP preimmunization.</p

Distribution of different subtypes of CGD according to sex.

*<p>Female X-linked patients are extremely lyonized heterozygous carrriers.</p

Cumulative survival of AR patients compared to XL patients.

<p><i>*Log rank statistics for difference in survival between X-linked and AR: 7.01 (p = 0.0081)</i>.</p

Gastrointestinal manifestations of CGD.

<p>Gastrointestinal manifestations of CGD.</p

Most frequently isolated micro-organisms.

<p>Most frequently isolated micro-organisms.</p

Involvement of kidneys and urinary tract (UT).

*<p>including three episodes of renal abscess.</p

Lymphadenitis.

<p>Lymphadenitis and cultured micro-organisms (in total 622 episodes in 213 patients). Percentages are the number of episodes with a positive culture of a certain pathogen divided by the total number of reported episodes.</p

Prevalence and causes of brain abscess.

<p>Prevalence and causes of brain abscess.</p