79 research outputs found
ΠΠΈΠΊΡΠΎΡΠ²Π΅ΡΠ΄ΠΎΡΡΡ Π²Π°Π»ΠΈΠΊΠΎΠ² ΠΈΠ· Π±ΡΠΎΠ½Π·Ρ ΠΠ-19Π-01, Π½Π°Π½Π΅ΡΠ΅Π½Π½ΡΡ ΠΊΠ°ΠΊ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠ°Ρ ΠΌΡΠ»ΡΠΈΠΌΠΎΠ΄Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠΊΡΡΡΠΈΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π»Π°Π·Π΅ΡΠ½ΠΎΠΉ Π½Π°ΠΏΠ»Π°Π²ΠΊΠΈ
Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° Π»Π°Π·Π΅ΡΠ½ΠΎΠΉ Π½Π°ΠΏΠ»Π°Π²ΠΊΠΈ ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π»Π°Π·Π΅ΡΠ½ΠΎΠΉ Π½Π°ΠΏΠ»Π°Π²ΠΊΠΈ Π΄Π»Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΠΌΡΠ»ΡΡΠΈΠΌΠΎΠ΄Π°Π»ΡΠ½ΡΡ
ΠΏΠΎΠΊΡΡΡΠΈΠΉ ΠΈΠ· ΡΠ°Π·Π½ΠΎΡΠΎΠ΄Π½ΡΡ
ΠΌΠ΅ΡΠ°Π»Π»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ². ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΌΠΈΠΊΡΠΎΡΠ²Π΅ΡΠ΄ΠΎΡΡΠΈ Π² ΠΏΠΎΠΏΠ΅ΡΠ΅ΡΠ½ΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ Π½Π°ΠΏΠ»Π°Π²Π»Π΅Π½Π½ΡΡ
Π²Π°Π»ΠΈΠΊΠΎΠ² ΠΈΠ· Π°Π»ΡΠΌΠΈΠ½ΠΈΠ΅Π²ΠΎΠΉ Π±ΡΠΎΠ½Π·Ρ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠΊΠΎΡΠΎΡΡΠΈ Π»Π°Π·Π΅ΡΠ½ΠΎΠΉ Π½Π°ΠΏΠ»Π°Π²ΠΊΠΈ Π½Π° ΠΌΠΈΠΊΡΠΎΡΠ²Π΅ΡΠ΄ΠΎΡΡΡ Π² Π½Π°ΠΏΠ»Π°Π²Π»Π΅Π½Π½ΡΡ
Π²Π°Π»ΠΈΠΊΠ°Ρ
.The advantages and the capabilities of laser cladding are analyses for used laser cladding for applying multimodal coatings from heterogeneous metal work materials. Results of microhardness investigations in cross section of cladding tracks from Al-bronze are exhibited. The influence of cladding velocity on microhardness are examined
ΠΠΈΠ½Π°ΠΌΠΈΠΊΠ° ΡΡΠΈΠΊΡΠΈΠΎΠ½Π½ΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΡΠΈ ΡΡΠ΅Π½ΠΈΠΈ Π½Π΅ΡΠΆΠ°Π²Π΅ΡΡΠ΅ΠΉ ΡΡΠ°Π»ΠΈ Π°ΡΡΡΠ΅Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° 12Π₯18Π10Π’ Ρ ΡΠ»ΡΡΡΠ°ΠΌΠ΅Π»ΠΊΠΎΠ·Π΅ΡΠ½ΠΈΡΡΠΎΠΉ ΡΡΡΡΠΊΡΡΡΠΎΠΉ
Π ΡΠ°Π±ΠΎΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΡΡΠΈΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΡΠΈ ΡΡΠ΅Π½ΠΈΠΈ ΠΎΠ±ΡΠ΅ΠΌΠ½ΡΡ
ΡΠ»ΡΡΡΠ°ΠΌΠ΅Π»ΠΊΠΎΠ·Π΅ΡΠ½ΠΈΡΡΡΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ². Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΡΡ
ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»Π°ΡΡ Π½Π΅ΡΠΆΠ°Π²Π΅ΡΡΠ°Ρ ΡΡΠ°Π»Ρ Π°ΡΡΡΠ΅Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° 12Π₯18Π10Π’ Ρ ΡΠ»ΡΡΡΠ°ΠΌΠ΅Π»ΠΊΠΎΠ·Π΅ΡΠ½ΠΈΡΡΠΎΠΉ ΡΡΡΡΠΊΡΡΡΠΎΠΉ, ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ABC ΠΏΡΠ΅ΡΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΏΡΠΎΠΊΠ°ΡΠΊΠΈ. Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΡΡ
ΠΎΠ³ΠΎ ΡΡΠ΅Π½ΠΈΡ ΡΠΊΠΎΠ»ΡΠΆΠ΅Π½ΠΈΡ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»Π°ΡΡ ΡΠ΅Π³ΠΈΡΡΡΠ°ΡΠΈΡ ΡΠΈΠ³Π½Π°Π»ΠΎΠ² Π²ΠΈΠ±ΡΠΎΡΡΠΊΠΎΡΠ΅Π½ΠΈΠΉ ΠΈ Π°ΠΊΡΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΌΠΈΡΡΠΈΠΈ
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄Π΅ΠΏΠ°ΡΠ°ΡΠΈΠ½ΠΈΠ·Π°ΡΠΈΠΈ Π΄ΠΈΠ·Π΅Π»ΡΠ½ΡΡ ΡΠΎΠΏΠ»ΠΈΠ²
ΠΠ±ΡΠ΅ΠΊΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΏΡΠΎΡΠ΅ΡΡ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄Π΅ΠΏΠ°ΡΠ°ΡΠΈΠ½ΠΈΠ·Π°ΡΠΈΠΈ Π΄ΠΈΠ·Π΅Π»ΡΠ½ΡΡ
ΡΠΎΠΏΠ»ΠΈΠ².
Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ°Π±ΠΎΡΡ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π³ΠΈΠ΄ΡΠΎΠ΄Π΅ΠΏΠ°ΡΠ°ΡΠΈΠ½ΠΈΠ·Π°ΡΠΈΠΈ Π΄ΠΈΠ·Π΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠΏΠ»ΠΈΠ²Π° ΠΏΡΡΠ΅ΠΌ ΠΏΠΎΠ΄Π±ΠΎΡΠ° ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΠΆΠΈΠΌΠΎΠ² Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»Π° ΡΠΎΠ·Π΄Π°Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ ΡΠ΅Π°ΠΊΡΠΎΡΠ° Π΄Π΅ΠΏΠ°ΡΠ°ΡΠΈΠ½ΠΈΠ·Π°ΡΠΈΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠΈΡΡΠ΅ΠΌΡ HYSYS, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° Π²Π»ΠΈΡΠ½ΠΈΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² Π½Π° ΠΏΡΠΎΡΠ΅ΡΡ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄Π΅ΠΏΠ°ΡΠ°ΡΠΈΠ½ΠΈΠ·Π°ΡΠΈΠΈ. ΠΠΎΠ΄ΠΎΠ±ΡΠ°Π½Ρ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠ΅ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π΄Π΅ΠΏΠ°ΡΠ°ΡΠΈΠ½ΠΈΠ·Π°ΡΠΈΠΈ Π΄Π»Ρ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° Π΄ΠΈΠ·Π΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠΏΠ»ΠΈΠ²Π° Π·ΠΈΠΌΠ½Π΅Π³ΠΎ ΠΈ Π°ΡΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΠΎΡΡΠ°Π²Π° ΡΡΡΡΡ.The object of research is the process of catalytic dewaxing of diesel fuels. The purpose of the work is to increase the efficiency of the catalytic hydrodewaxing of diesel fuel by selecting the optimal technological regimes using the mathematical modeling method. During the research, a model of a dewaxing reactor was developed using the HYSYS system, an assessment of the effect of process parameters on the catalytic dewaxing process was carried out. Optimum temperatures of the process of dewaxing for the production of winter and Arctic diesel oil, depending on the composition of the raw materials, were selected
Sequential (gemcitabine/vinorelbine) and concurrent (gemcitabine) radiochemotherapy with FDG-PET-based target volume definition in locally advanced non-small cell lung cancer: first results of a phase I/II study
BACKGROUND: The aim of the study was to determine the maximal tolerated dose (MTD) of gemcitabine every two weeks concurrent to radiotherapy, administered during an aggressive program of sequential and simultaneous radiochemotherapy for locally advanced, unresectable non-small cell lung cancer (NSCLC) and to evaluate the efficacy of this regime in a phase II study. METHODS: 33 patients with histologically confirmed NSCLC were enrolled in a combined radiochemotherapy protocol. 29 patients were assessable for evaluation of toxicity and tumor response. Treatment included two cycles of induction chemotherapy with gemcitabine (1200 mg/m(2)) and vinorelbine (30 mg/m(2)) at day 1, 8 and 22, 29 followed by concurrent radiotherapy (2.0 Gy/d; total dose 66.0 Gy) and chemotherapy with gemcitabine every two weeks at day 43, 57 and 71. Radiotherapy planning included [(18)F] fluorodeoxyglucose positron emission tomography (FDG PET) based target volume definition. 10 patients were included in the phase I study with an initial gemcitabine dose of 300 mg/m(2). The dose of gemcitabine was increased in steps of 100 mg/m(2 )until the MTD was realized. RESULTS: MTD was defined for the patient group receiving gemcitabine 500 mg/m(2 )due to grade 2 (next to grade 3) esophagitis in all patients resulting in a mean body weight loss of 5 kg (SD = 1.4 kg), representing 8% of the initial weight. These patients showed persisting dysphagia 3 to 4 weeks after completing radiotherapy. In accordance with expected complications as esophagitis, dysphagia and odynophagia, we defined the MTD at this dose level, although no dose limiting toxicity (DLT) grade 3 was reached. In the phase I/II median follow-up was 15.7 months (4.1 to 42.6 months). The overall response rate after completion of therapy was 64%. The median overall survival was 19.9 (95% CI: [10.1; 29.7]) months for all eligible patients. The median disease-free survival for all patients was 8.7 (95% CI: [2.7; 14.6]) months. CONCLUSION: After induction chemotherapy, the maximum tolerated dose and frequency of gemcitabine was defined at 500 mg/m(2 )every two weeks in three cycles during a maximum of 7 weeks of thoracic radiotherapy for the phase II study. This regimen represents an effective and tolerable therapy in the treatment of NSCLC
ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΠΉ ΠΏΠΎ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΏΠΎΠΆΠ°ΡΠ½ΠΎΠΉ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ Π² ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΡ ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡΡ
Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΡΡΡ Π²Π΅ΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΈ ΠΏΠ»Π°Π½ΠΈΡΡΡΡΠΈΡ
ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΠΉ ΠΏΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΠΎΠΆΠ°ΡΠ½ΠΎΠΉ Π·Π°ΡΠΈΡΡ Π² ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡΡ
Π ΠΎΡΡΠΈΠΈ. ΠΏΠΎΡΡΠ΄ΠΎΠΊ ΡΠ°Π±ΠΎΡΡ ΡΡΠΊΠΎΠ²ΠΎΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΉ ΠΏΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΠΉ ΠΆΠΈΠ·Π½Π΅Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΡΠ°ΡΠΈΡ
ΡΡ ΠΈ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»Π°.The article considers the whole complex of organizational and planning measures for conducting fire protection in educational institutions of Russia. the order of work of heads of educational organizations to ensure the safe functioning of students and staff
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