Dexamethasone Use and Mortality in Hospitalized Patients with Coronavirus Disease 2019: a Multicenter Retrospective Observational Study

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Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study

Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1–365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021. Findings: Advanced age (HR 2.77, 95%CI 2.53–3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03–4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55–5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14–1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37–0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17–1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20–1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45–1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80–13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10–1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32–1.67) and 365 days (RR 1.54, 95%CI 1.21–1.96) compared to COVID-19 patients with no AKI. Interpretation: COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. Funding: Authors are supported by various funders, with full details stated in the acknowledgement section

International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality

Given the growing number of prediction algorithms developed to predict COVID-19 mortality, we evaluated the transportability of a mortality prediction algorithm using a multi-national network of healthcare systems. We predicted COVID-19 mortality using baseline commonly measured laboratory values and standard demographic and clinical covariates across healthcare systems, countries, and continents. Specifically, we trained a Cox regression model with nine measured laboratory test values, standard demographics at admission, and comorbidity burden pre-admission. These models were compared at site, country, and continent level. Of the 39,969 hospitalized patients with COVID-19 (68.6% male), 5717 (14.3%) died. In the Cox model, age, albumin, AST, creatine, CRP, and white blood cell count are most predictive of mortality. The baseline covariates are more predictive of mortality during the early days of COVID-19 hospitalization. Models trained at healthcare systems with larger cohort size largely retain good transportability performance when porting to different sites. The combination of routine laboratory test values at admission along with basic demographic features can predict mortality in patients hospitalized with COVID-19. Importantly, this potentially deployable model differs from prior work by demonstrating not only consistent performance but also reliable transportability across healthcare systems in the US and Europe, highlighting the generalizability of this model and the overall approach

Progression du mycélium de Phomopsis so jae Lehm. à l’intérieur de la tige de soja

National audienceLatent infection by Phomopsis sojae has been shown. Seedlings are infested, but it is only on the senescent plant that the fungus gives symptoms and pycnidia. Mycelium progresses with the vegetative point, up to the fifth node. Upward this stage, floral induction delays mycelium progress, at two internodes from the vegetative point. On the senescent plant all parts are invaded. In one of the studied varieties, « Hodgson », the mycelium stays in the inferior internodes ; so, the number of contamined seeds is reduced.Le parasitisme de Phomopsis sojae est caractérisé par le phénomène de latence. La pénétration s’effectue au niveau des plantules et le champignon ne s’extériorise que sur la plante sénescente. Le mycélium progresse en même temps que le point végétatif tant que la plante n’a pas formé la 51 feuille. Au-delà, le processus floral est déclenché et le mycélium est retardé dans son cheminement ; on le localise à environ deux entre nœuds du point végétatif. Lors de la sénescence de la plante tous les organes sont envahis. Parmi les variétés testées, « Hodgson » présente un processus particulier : le mycélium reste localisé aux 3 entre nœuds inférieurs ; ainsi le nombre de graines contaminées est réduit

Peut-on utiliser les ECOS dans un but formatif?

PARIS7-Xavier Bichat (751182101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Action de l’herbicide molinate et de l’urée sur la sensibilité du riz à Sclerotium oryzae Catt. et à S. hydrophilum Sacc.

National audienceInfection of two rice varieties by Setimcrulo oryzae and S. hydrophilum was favoured by urea, but reduced by molinate. The herbicide slows Sclerotium development during the early growth stages of rice while urea favours the disease at all stages.L’action favorisante de l’urée et défavorable du molinate sur le développement des Sclerotium a été montrée pour 2 variétés de riz. L’action défavorable du molinate sur la maladie est plus importante que l’action favorisante de l’urée dans le cas de la variété la plus sensible. En culture, le molinate appliqué lors du semis (début mai) freine le développement des Sclerotium durant les premiers stades de développement. L’application tardive d’urée (mi-juillet) favorise l’extériorisation de la maladie

Évolution de la sensibilité des glumelles du riz à Pyricularia oryzae Cav. et à Drechslera oryzae (Br. de Haan) Sub. et Jain : conséquences pour la transmission des maladies

National audiencePyricularia and Drechslera of rice may survive on and be transmitted by rice seeds. Artificial inoculations made on rice panicies have shown the short time during which palea and lemma are susceptible. From anthesis, the anatomy is modified so that a barrier prevents infection. Lemmas and paleas infected early permit localization of the mycelium and conidia between the glumella and caryopsis. During seed germination, infections on the coleoptiles and sheaths of the first leaves can be seen.Les contaminations artificielles réalisées sur les panicules de riz ont permis de constater la courte durée de la sensibilité des glumelles à la pénétration par Pyricularia oryzae et Drechslera oryzae. Dès l’anthèse, l’évolution anatomique des tissus des glumelles aboutit à une barrière s’opposant à toute pénétration ultérieure. Les contaminations avant l’anthèse ont pour conséquence l’invasion des glumelles par les champignons étudiés et la localisation du mycélium et des conidies entre les glumelles et le caryopse, permettant ainsi à ces champignons de se maintenir pendant la mauvaise saison. A la germination de la graine, on observe des nécroses sur le coléoptile, puis sur les gaines des premières feuilles

Action in vitro d’un herbicide (molinate) sur trois champignons parasites du riz : Sclerotium oryzae Catt., S. hydrophilum Sacc. et Rhizoctonia oryzae Ryker et Gooch

National audienceMolinate has a fungistatic effect in vitro on fungal parasites of rice. At molinate concentrations lower than 0.5 g/l, it induces a lower development of mycelium, and sclerotia take.longer to differentiate. In addition, at these and higher concentrations, the longer the contact with the herbicide, the more difficult it is for the fungi to start growing. The delayed infection of rice plants in plots treated with molinate could be due to such an action on these fungi.Le molinate, herbicide utilisé en riziculture, présente une action fongistatique in vitro sur trois champignons parasites du riz (Sclerotium oryzae, S. hydrophilum, Rhizoctonia oryzae). A des concentrations inférieures à 0,5 g/1 de matière active, il provoque un ralentissement de leur développement et les sclérotes sont plus longs à se former. En outre, à ces mêmes concentrations ou à des concentrations supérieures, la reprise d’activité des champignons étudiés est d’autant plus difficile que la durée de contact est plus longue. Les attaques tardives du riz dans les parcelles traitées au molinate pourraient être expliquées par une telle action

Évolution de la sensibilité des glumelles du riz à Pyricularia oryzae Cav. et à Drechslera oryzae (Br. de Haan) Sub. et Jain : conséquences pour la transmission des maladies

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