The capabilities approach and critical social policy: lessons from the majority world?

The capabilities approach (CA) most closely associated with the thinner and thicker versions of Sen and Nussbaum has the potential to provide a paradigm shift for critical social policy, encompassing but also transcending some of the limitations associated with the Marshallian social citizenship approach. The article argues, however, that it cannot simply be imported from the majority world, rather there is a need to bear in mind the critical literature that developed around it. This is generally discussed and then critically applied to case studies of CA in the developed capitalist world, particularly the Equalities Review conducted for the Equality and Human Rights Commission

Spontaneous symmetry breaking on the lattice generated by Yukawa interaction

We study by numerical simulation a lattice Yukawa model with naive fermions at intermediate values of the Yukawa coupling $y$ when the nearest neighbour coupling \kp of the scalar field $\Phi$ is very weakly ferromagnetic (\kp \approx 0) or even antiferromagnetic ($\kappa < 0$) and the nonvanishing value of \vev is generated by the Yukawa interaction. The renormalized Yukawa coupling $y_R$ achieves here its maximal value and this $y$-region is thus of particular importance for lattice investigations of strong Yukawa interaction. However, here the scalar field propagators have a very complex structure caused by fermion loop corrections and by the proximity of phases with antiferromagnetic properties. We develop methods for analyzing these propagators and for extracting the physical observables. We find that going into the negative \kp region, the scalar field renormalization constant becomes small and $y_R$ does not seem to exceed the unitarity bound, making the existence of a nontrivial fixed point in the investigated Yukawa model quite unlikely.Comment: 22 pages plus 13 figure

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat