Rapid fabrication of microfluidic PDMS devices from reusable PDMS molds using laser ablation

GULER, MUSTAFA TAHSIN/0000-0002-0478-3183; Elbuken, Caglar/0000-0001-8359-6871WOS: 000375230700008The conventional fabrication methods for microfluidic devices require cleanroom processes that are costly and time-consuming We present a novel, facile, and low-cost method for rapid fabrication of polydimethylsiloxane (PDMS) molds and devices. The method consists of three main fabrication steps: female mold (FM), male mold (MM), and chip fabrication. We use a CO, laser cutter to pattern a thin, spin -coated PDMS layer for FM fabrication. We then obtain reusable PDMS MM from the FM using PDMS/PDMS casting. Finally, a second casting step is used to replicate PDMS devices from the MM. Demolding of one PDMS layer from another is carried out without any potentially hazardous chemical surface treatment. We have successfully demonstrated that this novel method allows fabrication of microfluidic molds and devices with precise dimensions (thickness, width, length) using a single material, PDMS, which is very common across microfluidic laboratories. The whole process, from idea to device testing, can be completed in 1.5 h in a standard laboratory.European UnionEuropean Union (EU) [322019]This project was partially supported by European Union FP7 Marie Curie Career Integration Grant (no. 322019)