DESIGN AND DEVELOPMENT OF A WIRELESS QUEUING SYSTEM

This study aims to provide a solution to a physical queue in some service departments of Adventist University of the Philippines using a wireless queuing system that is easy to manage, flexible, easy to install and it has low power consumption.   The wireless queuing system is divided into hardware and system software. The hardware consists of two section, controller section, and a receiver section. The controller section has four controllers which are responsible for setting and transmitting  queue numbers. The receiver section is responsible for receiving the data, data processing, and displaying queue numbers in display monitor. Each counter controller is powered by an Atmega 328P microcontroller, a single radio transceiver that operates at 2.5 GHz  frequency,  a 32-character  liquid crystal display,  and a 12-button keypad. While  the receiver is powered by a single-board computer Raspberry Pi 2, Atmega 328P microcontroller,  single radio transceiver and it is connected to a display that has an HDMI (High-Definition   Multimedia Interface) input. The implementation of the system software is classified into four parts: the receiver device configurations,  the graphical user interface (GUI), the controller and the receiver. These software divisions complement each other to create a functional queuing system. The wireless queuing system is also capable of posting advertisements to promote ideas, products, and services

Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma

Understanding the biological and clinical impact ofcopy number aberrations (CNA)for the development of precision therapies in cancer remains anunmet challenge. Genetic amplification of chromosome 1q (chr1q-amp) is a major CNAconferring adverse prognosis in several types of cancer, including in the blood cancer multiple myeloma (MM). Although severalgenes across chr1q portend high-risk MM disease, the underpinning molecular aetiology remains elusive. Here, with reference to the 3D chromatin structure, we integrate MMpatient multi-omics datasets with genetic variables to obtain an associated clinical risk map across chr1q and to identify 103 adverse prognosis genes in chr1q-amp MM. Prominent amongst these genes, the transcription factor PBX1 is ectopically expressed by genetic amplification and epigenetic activation of its own preserved 3D regulatory domain. By binding to reprogrammed super-enhancers, PBX1 directly regulates critical oncogenic pathways and a FOXM1-dependent transcriptional programme. Together, PBX1 and FOXM1 activate a proliferative gene signature which predicts adverse prognosis across multiple types of cancer. Notably, pharmacological disruption of the PBX1-FOXM1 axis with existing agents (thiostrepton) and a novel PBX1 small-molecule inhibitor (T417) is selectively toxic against chr1q-amplified myeloma and solid tumour cells. Overall, our systems medicine approach successfully identifies CNA-driven oncogenic circuitries, links them to clinical phenotypes and proposes novel CNA-targeted therapystrategies in multiple myeloma and other types of cancer

Erythropoietin signaling regulates heme biosynthesis. 1

Abstract 34 Heme is required for survival of all cells, and in most eukaryotes, is produced through a 35 series of eight enzymatic reactions. Although heme production is critical for many 36 cellular processes, how it is coupled to cellular differentiation is unknown. Here, usin

Demonstration of ignition radiation temperatures in indirect-drive inertial confinement fusion hohlraums

We demonstrate the hohlraum radiation temperature and symmetry required for ignition-scale inertial confinement fusion capsule implosions. Cryogenic gas-filled hohlraums with 2.2 mm-diameter capsules are heated with unprecedented laser energies of 1.2 MJ delivered by 192 ultraviolet laser beams on the National Ignition Facility. Laser backscatter measurements show that these hohlraums absorb 87% to 91% of the incident laser power resulting in peak radiation temperatures of TRAD=300  eV and a symmetric implosion to a 100  μm diameter hot core