The rotating wall machine: A device to study ideal and resistive magnetohydrodynamic stability under variable boundary conditions The rotating wall machine: A device to study ideal and resistive magnetohydrodynamic stability under variable boundary condit

The rotating wall machine, a basic plasma physics experimental facility, has been constructed to study the role of electromagnetic boundary conditions on current-driven ideal and resistive magnetohydrodynamic instabilities, including differentially rotating conducting walls. The device, a screw pinch magnetic geometry with line-tied ends, is described. The plasma is generated by an array of 19 plasma guns that not only produce high density plasmas but can also be independently biased to allow spatial and temporal control of the current profile. The design and mechanical performance of the rotating wall as well as diagnostic capabilities and internal probes are discussed. Measurements from typical quiescent discharges show the plasma to be high β (≤ p > 2μ 0 /B 2 z ), flowing, and well collimated. Internal probe measurements show that the plasma current profile can be controlled by the plasma gun array

The rotating wall machine: A device to study ideal and resistive magnetohydrodynamic stability under variable boundary conditions

The rotating wall machine, a basic plasma physics experimental facility, has been constructed to study the role of electromagnetic boundary conditions on current-driven ideal and resistive magnetohydrodynamic instabilities, including differentially rotating conducting walls. The device, a screw pinch magnetic geometry with line-tied ends, is described. The plasma is generated by an array of 19 plasma guns that not only produce high density plasmas but can also be independently biased to allow spatial and temporal control of the current profile. The design and mechanical performance of the rotating wall as well as diagnostic capabilities and internal probes are discussed. Measurements from typical quiescent discharges show the plasma to be high β (≤ p > 2μ 0 /B 2 z ), flowing, and well collimated. Internal probe measurements show that the plasma current profile can be controlled by the plasma gun array

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this fusion oncogene also results in the development of myeloid leukemia, it is with long latency. To identify mutations that cooperate with Mll-AF9, we infected neonatal wild-type (WT) or Mll-AF9 mice with a murine leukemia virus (MuLV). MuLV-infected Mll-AF9 mice succumbed to disease significantly faster than controls presenting predominantly with myeloid leukemia while infected WT animals developed predominantly lymphoid leukemia. We identified 88 candidate cancer genes near common sites of proviral insertion. Analysis of transcript levels revealed significantly elevated expression of Mn1, and a trend toward increased expression of Bcl11a and Fosb in Mll-AF9 murine leukemia samples with proviral insertions proximal to these genes. Accordingly, FOSB and BCL11A were also overexpressed in human AML harboring MLL gene translocations. FOSB was revealed to be essential for growth in mouse and human myeloid leukemia cells using shRNA lentiviral vectors in vitro. Importantly, MN1 cooperated with Mll-AF9 in leukemogenesis in an in vivo BM viral transduction and transplantation assay. Together, our data identified genes that define transcription factor networks and important genetic pathways acting during progression of leukemia induced by MLL fusion oncogenes. (Blood. 2012; 119(19): 4512-4523