Assessing the Effects of Partisan Bias at the Group Level of Analysis: A Hidden Profile Experiment

Although there is some evidence in the political arena that pooling information can overcome individual biases to improve decision-making accuracy, research from the group communication and psychology arenas suggests otherwise. Specifically, research on the hidden profile, a group-level decision-making problem, suggests that groups are decidedly biased when making decisions. This laboratory experiment tested whether or not partisan biases manifest at the group level of analysis. In the main, it was found that groups composed of either all Republican or all Democratic group members were likely to make a decision that was consonant with their party’s political ideology, which ultimately impacted hidden profile solution rates (i.e., decision accuracy). Moreover, supplemental analyses suggest that Republican and Democratic groups reached their biased decisions through different means. A discussion is provided in which the implications of these results are considered

Phase Ib trial of inhaled iloprost for the prevention of lung cancer with predictive and response biomarker assessment

Introduction: Iloprost, a prostacyclin analog, has lung cancerpreventive activity in preclinical models and improved dysplasia in former smokers in a phase IIb trial. Oral iloprost is currently unavailable. We performed a phase Ib trial of inhaled iloprost in former smokers to assess tolerance and compliance. Methods: Participants self-administered nebulized iloprost (5ug) or placebo four (QID) or two (BID) times daily. As QID dose was well tolerated and due to expiration of the placebo, the BID dosing and placebo were eliminated early on in the trial. Bronchoscopy with biopsyat six standard sites was performed at treatment initiation and two months post-iloprost, with exploratory histological analysis. Bulk RNA sequencing, single cell RNA sequencing and an in vitro assay of epithelial progenitor cell iloprost response were performed on a subset of biopsies in an exploratory investigation of response mechanisms and predictive biomarkers. Results and discussion: Thirty-four of a planned 48 participants were recruited to the trial.Inhaled iloprost was well tolerated with no adverse events \u3e grade 2. Compliance was 67% in the QID group. The trial was not powered to detect histologic response and none was found. Bulk RNA sequencing of biopsies pre/post iloprost suggest that iloprost is immunomodulatory and downregulates cell proliferation pathways. Single cell RNA sequencing showed an increase in CD8-positive T cells with upregulation of genes in interferon γ signaling. In vitro iloprost response by epithelial progenitor cells correlated with histologic response with kappa coefficient of 0.81 (95% CI 0.47, 1.0). Inhaled iloprost was well tolerated with suboptimal compliance. Molecular analysis suggested that iloprosthas immunomodulatory and antiproliferative effects.The progenitor cell iloprost response assay may be a promising avenue to develop predictive biomarkers. Clinical trial registration: https://clinicaltrials.gov/study/NCT02237183, identifier NCT02237183