A soy-yoghurt-honey product as a therapeutic functional food: mode of action and narrative review

Meal replacements and food supplements are now popular commercial weight loss and nutrition products. This review describes the efficacy, effectiveness, and therapeutic use of one such product - a soy-yoghurt-honey food formulation. The original formula of this product was created more than thirty years ago and since that time it has become well established as a food supplement supporting a healthy lifestyle. Therapeutic evidence for this product is based on numerous scientific studies and clinical trials, focusing particularly on weight management and associated metabolic risk factors and published as peer-reviewed articles. Given the availability of the product and the extent to which it has been experimentally evaluated, it is timely and important that the research is brought together under a single review to consolidate the understanding for the scientific and clinical communities. This review discusses the ingredients and the broad mechanisms of action, which are probably due to the biological properties of the three base components - soy, milk, and honey. It further summarizes and discusses the laboratory and clinical intervention studies, including the biochemical and metabolic mechanisms regarding the insulin- and lipid-lowering, anti-hypertensive, anti-inflammatory, antioxidant, and anti-microbial properties of the overall food and its base products

Geschichte der Wolmarschen Kreisschule nebst Andeutungen über die Bildungsgeschichte Livlands : Programm zur festlichen Einweihung des neuen Schullocals, am [24.] September 1847

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Weight loss strategies and the risk of skeletal muscle mass loss

With energy intake restriction and exercise remaining the key diet and lifestyle approaches to weight loss, this is not without potential negative implications for body composition, metabolic health, and quality and quantity of life. Ideally, weight loss should be derived almost exclusively from the fat mass compartment as this is the main driver of metabolic disease, however, several studies have shown that there is an accompanying loss of tissue from the fat-free compartment, especially skeletal muscle. Population groups including post-menopausal women, the elderly, those with metabolic disease and athletes may be particularly at risk of skeletal muscle loss when following a weight management programme. Research studies that have addressed this issue across a range of population groups are reviewed with a focus upon the contribution of resistance and endurance forms of exercise and a higher intake dietary protein above the current guideline of 0.8 g/kg body weight/day. While findings can be contradictory, overall, the consensus appears that fat-free and skeletal muscle masses can be preserved, albeit to varying degrees by including both forms of exercise (but especially resistance forms) in the weight management intervention. Equally, higher intakes of protein can protect loss of these body compartments, acting either separately or synergistically with exercise. Elderly individuals in particular may benefit most from this approach. Thus, the evidence supports the recommendations for intakes of protein above the current guidelines of 0.8 g/kg body weight/d for the healthy elderly population to also be incorporated into the dietary prescription for weight management in this age group

Frequency of secondary dyslipidemia in obese children

Ulrike Korsten-Reck1, Katrin Kromeyer-Hauschild2, Katrin Korsten1, Manfred W Baumstark1, Hans-H Dickhuth1, Aloys Berg11Department of Rehabilitative and Preventive Sports Medicine, University Medical Center, University of Freiburg, 79106 Freiburg, Germany; 2Institute of Human Genetics and Anthropology, Friedrich-Schiller-University Jena, 07740 Jena, GermanyObjective: This paper reports the frequency, type, and degree of dyslipidemia in obese children before therapeutic intervention. The relationships between lipid values and weight status, as well as lipid values and physical fitness, of these children were also investigated.Design and methods: The initial examination of the Freiburg Intervention Trial for Obese Children (FITOC) measured the values of triglycerides (TG), total cholesterol (C), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in 546 obese children aged 7–12 (body mass index [BMI] > 97th percentile), and compared these values with those of the age- and sex-specific reference group in the Lipid Research Clinics Population Studies Data Book (LRC). Four groups were selected according to the following scheme: A, Normolipidemia; B, Hyper-LDL-cholesterolemia alone; C, Hypo-HDL-C + hypertriglyceridemia; D, Combined hyperlipidemia = Hyper-LDL-C + hypertriglyceridemia. Body mass index, BMI-SDS (corrected BMI), and physical performance in watt/kg body weight were measured.Results: A total of 45.8% of the overweight children showed an abnormal lipid profile. Ten percent of the children had high LDL-C levels (group B), while 15% had increased LDL-C and increased TG (group D) (higher prevalence in boys). In 18.9% we found increased TG, combined with decreased HDL-C values (group C).Conclusion: Obese children are at risk of dyslipoproteinemia and related diseases. Children with the highest BMI-SDS and lowest physical fitness have the lowest HDL-C values and increased TG, indicating a higher risk for the metabolic syndrome.Keywords: atherosclerotic risk, childhood, dyslipidemia, obesit

A 12-Month Lifestyle Intervention Program Improves Body Composition and Reduces the Prevalence of Prediabetes in Obese Patients

Background: The present study investigated the effects of a 12-month interdisciplinary standardized lifestyle program addressing physical activity and changes in dietary and lifestyle behavior in 2,227 obese prediabetic participants. Methods: Measures of obesity (BMI, waist circumference), cardiopulmonary fitness, and metabolic parameters were determined before and after the intervention period. Results: From the 2,227 participants who were initially prediabetic, 839 participants (-37.7%) did no longer show the criteria of prediabetes after the intervention and had normal HbA1c levels. Conclusion: The clinical effects are substantial, and it is likely that the applied intense and multidisciplinary lifestyle interventions could reduce the risk of developing diabetes and the prevalence of a full-blown metabolic syndrome in obese and prediabetic patients

Urban Green Parks for Long-term Subjective Well-being: Empirical Relationships between Personal Characteristics, Park Characteristics, Park Use, Sense of Place, and Satisfaction with Life in the Netherlands

As our living environment is becoming increasingly urbanized, this puts the livability, health, and quality of life in cities under pressure. Due to the urbanization process, urban green spaces are under threat of becoming scarce, while it is recognized that these green spaces can positively contribute to the subjective well-being of citizens. It is thus important to maximize the use and benefits derived from green spaces by designing them as positively experienced places. The aim of this research is to gain more empirical insights on the relationships between personal and park characteristics, park use behavior, sense of place, and park visitors’ long-term subjective well-being (i.e., life satisfaction). An online questionnaire was administered to participants in two medium-sized cities in The Netherlands, namely Eindhoven and ‘s-Hertogenbosch. Data were analyzed using a structural equation model. The results of this study show that the appreciation of facilities and the absence of disturbances positively influence the use and sense of place of a park. Furthermore, the findings show that sense of place has a positive influence on life satisfaction. The findings can be used by designers and policy-makers as guidelines to improve existing parks or to design new parks that support the subjective well-being of individuals in The Netherlands

Prediabetes conversion to Normoglycemia is superior adding a low-carbohydrate and energy deficit formula diet to lifestyle intervention - a 12-month subanalysis of the ACOORH trial

Lifestyle interventions have been shown to reverse hyperglycemia to normoglycemia. However, these effects are not long-lasting and are accompanied with high dropout rates. As formula diets have been shown to be simple in usage and effective in improving glycemic control, we hypothesised that adding a low-carbohydrate and energy deficit formula diet to a low-intensity lifestyle intervention is superior in reversing prediabetes compared with lifestyle intervention alone. In this predefined subanalysis of an international, multicenter randomised controlled trial (Almased Concept against Overweight and Obesity and Related Health Risk (ACOORH) study (ID DRKS00006811)), 141 persons with prediabetes were randomised (1:2) into either a control group with lifestyle intervention only (CON, n = 45) or a lifestyle intervention group accompanied with a formula diet (INT, n = 96). Both groups were equipped with telemonitoring devices. INT received a low-carbohydrate formula diet substituting three meals/day (~1200 kcal/day) within the first week, two meals/day during week 2–4, and one meal/day during week 5–26 (1300–1500 kcal/day). Follow-up was performed after 52 weeks and 105 participants (75%, INT: n = 74; CON: n = 31) finished the 26-week intervention phase. Follow-up data after 52 weeks were available from 93 participants (66%, INT: n = 65; CON: n = 28). Compared with CON, significantly more INT participants converted to normoglycemia after 52 weeks (50% vs. 31%; p 0.05). The risk reduction led to a number-needed-to-treat of 5.3 for INT. Lifestyle intervention with a low-carbohydrate formula diet reduces prediabetes prevalence stronger than lifestyle intervention alone and is effective for type 2 diabetes prevention

Effect of a supplement rich in alkaline minerals on acid-base balance in humans

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High-protein, low-glycaemic meal replacement decreases fasting insulin and inflammation markers — a 12-month subanalysis of the ACOORH trial

Abstract: Lifestyle interventions, including meal replacement, are effective in the prevention and treatment of type-2-diabetes and overweight. Since insulin is the key weight regulator, we hypothesised that addition of meal replacement to a lifestyle intervention reduces insulin levels more effective than lifestyle intervention alone. In the international, multicenter randomised-controlled ACOORH-trial (Almased-Concept-against-Overweight-and-Obesity-and-Related-Health-Risk) overweight or obese persons with criteria of metabolic syndrome (n=463) were randomised into two groups. Both groups received nutritional advice focussing on carbohydrate restriction and telemonitoring devices. The intervention group substituted all three main meals/day in week 1, two meals/day in week 2–4, and one meal/day in week 5–26 with a protein-rich, low-glycaemic meal replacement. Data were collected at baseline, after 1, 3, 6 and 12 months. All datasets providing insulin data (n=446) were included in this predefined subanalysis. Significantly stronger reductions of insulin (-3.3±8.7μU/ml vs. -1.6±9.8μU/ml), weight (-6.1±5.kg vs. -3.2±4.6kg) and inflammation markers were observed in the intervention group. Insulin reduction correlated with weight reduction and strongest weight loss (-7.6±4.9kg) was observed in those participants with insulin decrease >2μU/ml. These results underline the potential of meal replacement-based lifestyle interventions in diabetes prevention, and measurement of insulin may serve as an indicator for adherence to carbohydrate restriction