504 research outputs found
Transitivity, Time Consumption, and Quality of Preference Judgments in Crowdsourcing
Preference judgments have been demonstrated as a better alternative to graded judgments to assess the relevance of documents relative to queries. Existing work has verified transitivity among preference judgments when collected from trained judges, which reduced the number of judgments dramatically. Moreover, strict preference judgments and weak preference judgments, where the latter additionally allow judges to state that two documents are equally relevant for a given query, are both widely used in literature. However, whether transitivity still holds when collected from crowdsourcing, i.e., whether the two kinds of preference judgments behave similarly remains unclear. In this work, we collect judgments from multiple judges using a crowdsourcing platform and aggregate them to compare the two kinds of preference judgments in terms of transitivity, time consumption, and quality. That is, we look into whether aggregated judgments are transitive, how long it takes judges to make them, and whether judges agree with each other and with judgments from TREC. Our key findings are that only strict preference judgments are transitive. Meanwhile, weak preference judgments behave differently in terms of transitivity, time consumption, as well as of quality of judgment
Diversifying Search Results Using Time
Getting an overview of a historic entity or event can be difficult in search results, especially if important dates concerning the entity or event are not known beforehand. For such information needs, users would benefit if returned results covered diverse dates, thus giving an overview of what has happened throughout history. Diversifying search results based on important dates can be a building block for applications, for instance, in digital humanities. Historians would thus be able to quickly explore longitudinal document collections by querying for entities or events without knowing associated important dates apriori. In this work, we describe an approach to diversify search results using temporal expressions (e.g., in the 1990s) from their contents. Our approach first identifies time intervals of interest to the given keyword query based on pseudo-relevant documents. It then re-ranks query results so as to maximize the coverage of identified time intervals. We present a novel and objective evaluation for our proposed approach. We test the effectiveness of our methods on the New York Times Annotated corpus and the Living Knowledge corpus, collectively consisting of around 6 million documents. Using history-oriented queries and encyclopedic resources we show that our method indeed is able to present search results diversified along time
Leveraging Semantic Annotations to Link Wikipedia and News Archives
The incomprehensible amount of information available online has made it difficult to retrospect on past events. We propose a novel linking problem to connect excerpts from Wikipedia summarizing events to online news articles elaborating on them. To address the linking problem, we cast it into an information retrieval task by treating a given excerpt as a user query with the goal to retrieve a ranked list of relevant news articles. We find that Wikipedia excerpts often come with additional semantics, in their textual descriptions, representing the time, geolocations, and named entities involved in the event. Our retrieval model leverages text and semantic annotations as different dimensions of an event by estimating independent query models to rank documents. In our experiments on two datasets, we compare methods that consider different combinations of dimensions and find that the approach that leverages all dimensions suits our problem best
{YAGO}2: A Spatially and Temporally Enhanced Knowledge Base from {Wikipedia}
We present YAGO2, an extension of the YAGO knowledge base, in which entities, facts, and events are anchored in both time and space. YAGO2 is built automatically from Wikipedia, GeoNames, and WordNet. It contains 80 million facts about 9.8 million entities. Human evaluation confirmed an accuracy of 95\% of the facts in YAGO2. In this paper, we present the extraction methodology, the integration of the spatio-temporal dimension, and our knowledge representation SPOTL, an extension of the original SPO-triple model to time and space
Improved Implementation of Point Location in General Two-Dimensional Subdivisions
We present a major revamp of the point-location data structure for general
two-dimensional subdivisions via randomized incremental construction,
implemented in CGAL, the Computational Geometry Algorithms Library. We can now
guarantee that the constructed directed acyclic graph G is of linear size and
provides logarithmic query time. Via the construction of the Voronoi diagram
for a given point set S of size n, this also enables nearest-neighbor queries
in guaranteed O(log n) time. Another major innovation is the support of general
unbounded subdivisions as well as subdivisions of two-dimensional parametric
surfaces such as spheres, tori, cylinders. The implementation is exact,
complete, and general, i.e., it can also handle non-linear subdivisions. Like
the previous version, the data structure supports modifications of the
subdivision, such as insertions and deletions of edges, after the initial
preprocessing. A major challenge is to retain the expected O(n log n)
preprocessing time while providing the above (deterministic) space and
query-time guarantees. We describe an efficient preprocessing algorithm, which
explicitly verifies the length L of the longest query path in O(n log n) time.
However, instead of using L, our implementation is based on the depth D of G.
Although we prove that the worst case ratio of D and L is Theta(n/log n), we
conjecture, based on our experimental results, that this solution achieves
expected O(n log n) preprocessing time.Comment: 21 page
Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9
Objective: The cyclin-dependent kinase (CDK) inhibitor flavopiridol is currently being tested in clinical trials as anticancer drug. Beyond its cell death–inducing action, we hypothesized that flavopiridol affects inflammatory processes. Therefore, we elucidated the action of flavopiridol on leukocyte–endothelial cell interaction and endothelial activation in vivo and in vitro and studied the underlying molecular mechanisms.
Methods and Results: Flavopiridol suppressed concanavalin A–induced hepatitis and neutrophil infiltration into liver tissue. Flavopiridol also inhibited tumor necrosis factor-α–induced leukocyte– endothelial cell interaction in the mouse cremaster muscle. Endothelial cells were found to be the major target of flavopiridol, which blocked the expression of endothelial cell adhesion molecules (intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin), as well as NF-κB-dependent transcription. Flavopiridol did not affect inhibitor of κB (IκB) kinase, the degradation and phosphorylation of IκBα, nuclear translocation of p65, or nuclear factor-κB (NF-κB) DNA-binding activity. By performing a cellular kinome array and a kinase activity panel, we found LIM domain kinase-1 (LIMK1), casein kinase 2, c-Jun N-terminal kinase (JNK), protein kinase Cθ (PKCθ), CDK4, CDK6, CDK8, and CDK9 to be influenced by flavopiridol. Using specific inhibitors, as well as RNA interference (RNAi), we revealed that only CDK9 is responsible for the action of flavopiridol.
Conclusion: Our study highlights flavopiridol as a promising antiinflammatory compound and inhibition of CDK9 as a novel approach for the treatment of inflammation-associated diseases
Well-balanced treatment of gravity in astrophysical fluid dynamics simulations at low Mach numbers
Accurate simulations of flows in stellar interiors are crucial to improving
our understanding of stellar structure and evolution. Because the typically
slow flows are merely tiny perturbations on top of a close balance between
gravity and the pressure gradient, such simulations place heavy demands on
numerical hydrodynamics schemes. We demonstrate how discretization errors on
grids of reasonable size can lead to spurious flows orders of magnitude faster
than the physical flow. Well-balanced numerical schemes can deal with this
problem. Three such schemes were applied in the implicit, finite-volume
Seven-League Hydro (SLH) code in combination with a low-Mach-number numerical
flux function. We compare how the schemes perform in four numerical experiments
addressing some of the challenges imposed by typical problems in stellar
hydrodynamics. We find that the - and deviation well-balancing
methods can accurately maintain hydrostatic solutions provided that
gravitational potential energy is included in the total energy balance. They
accurately conserve minuscule entropy fluctuations advected in an isentropic
stratification, which enables the methods to reproduce the expected scaling of
convective flow speed with the heating rate. The deviation method also
substantially increases accuracy of maintaining stationary orbital motions in a
Keplerian disk on long timescales. The Cargo-LeRoux method fares substantially
worse in our tests, although its simplicity may still offer some merits in
certain situations. Overall, we find the well-balanced treatment of gravity in
combination with low Mach number flux functions essential to reproducing
correct physical solutions to challenging stellar slow-flow problems on
affordable collocated grids.Comment: Accepted for publication in A&
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