Berry Curvature in Graphene: A New Approach

In the present paper we have directly computed the Berry curvature terms relevant for Graphene in the presence of an \textit{inhomogeneous} lattice distortion. We have employed the generalized Foldy Wouthuysen framework, developed by some of us \cite{ber0,ber1,ber2}. We show that a non-constant lattice distortion leads to a valley-orbit coupling which is responsible to a valley-Hall effect. This is similar to the valley-Hall effect induced by an electric field proposed in \cite{niu2} and is the analogue of the spin-Hall effect in semiconductors \cite{MURAKAMI, SINOVA}. Our general expressions for Berry curvature, for the special case of homogeneous distortion, reduce to the previously obtained results \cite{niu2}. We also discuss the Berry phase in the quantization of cyclotron motion.Comment: Slightly modified version, to appear in EPJ

The persistence of a chlorophyll spectral biosignature from Martian evaporite and spring analogues under Mars-like conditions

Spring and evaporite deposits are considered two of the most promising environments for past habitability on Mars and preservation of biosignatures. Manitoba, Canada hosts the East German Creek (EGC) hypersaline spring complex, and the post impact evaporite gypsum beds of the Lake St. Martin (LSM) impact. The EGC complex has microbial mats, sediments, algae and biofabrics, while endolithic communities are ubiquitous in the LSM gypsum beds. These communities are spectrally detectable based largely on the presence of a chlorophyll absorption band at 670 nm; however, the robustness of this feature under Martian surface conditions was unclear. Biological and biology-bearing samples from EGC and LSM were exposed to conditions similar to the surface of present day Mars (high UV flux, 100 mbar, anoxic, CO_2 rich) for up to 44 days, and preservation of the 670 nm chlorophyll feature and chlorophyll red-edge was observed. A decrease in band depth of the 670 nm band ranging from ∼16 to 80% resulted, with correlations seen in the degree of preservation and the spatial proximity of samples to the spring mound and mineral shielding effects. The spectra were deconvolved to Mars Exploration Rover (MER) Pancam and Mars Science Laboratory (MSL) Mastcam science filter bandpasses to investigate the detectability of the 670 nm feature and to compare with common mineral features. The red-edge and 670 nm feature associated with chlorophyll can be distinguished from the spectra of minerals with features below ∼1000 nm, such as hematite and jarosite. However, distinguishing goethite from samples with the chlorophyll feature is more problematic, and quantitative interpretation using band depth data makes little distinction between iron oxyhydroxides and the 670 nm chlorophyll feature. The chlorophyll spectral feature is observable in both Pancam and Mastcam, and we propose that of the proposed EXOMARS Pancam filters, the PHYLL filter is best suited for its detection

Holonomy of Einstein Lorentzian manifolds

The classification of all possible holonomy algebras of Einstein and vacuum Einstein Lorentzian manifolds is obtained. It is shown that each such algebra appears as the holonomy algebra of an Einstein (resp., vacuum Einstein) Lorentzian manifold, the direct constructions are given. Also the holonomy algebras of totally Ricci-isotropic Lorentzian manifolds are classified. The classification of the holonomy algebras of Lorentzian manifolds is reviewed and a complete description of the spaces of curvature tensors for these holonomies is given.Comment: Dedicated to to Mark Volfovich Losik on his 75th birthday. This version is an extended part of the previous version; another part of the previous version is extended and submitted as arXiv:1001.444

A proteinase 3 contribution to juvenile idiopathic arthritis-associated cartilage damage

A full understanding of the molecular mechanisms implicated in the etiopathogenesis of juvenile idiopathic arthritis (JIA) is lacking. A critical role for leukocyte proteolytic activity (e.g., elastase and cathepsin G) has been proposed. While leukocyte elastase’s (HLE) role has been documented, the potential contribution of proteinase 3 (PR3), a serine protease present in abundance in neutrophils, has not been evaluated. In this study we investigated: (1) PR3 concentrations in the synovial fluid of JIA patients using ELISA and (2) the cartilage degradation potential of PR3 by measuring the hydrolysis of fluorescently labeled collagen II in vitro. In parallel, concentrations and collagen II hydrolysis by HLE were assessed. Additionally, the levels of the co-secreted primary granule protein myeloperoxidase (MPO) were assessed in synovial fluid of patients diagnosed with JIA. We report the following levels of analytes in JIA synovial fluid: PR3—114 ± 100 ng/mL (mean ± SD), HLE—1272 ± 1219 ng/mL, and MPO—1129 ± 1659 ng/mL, with a very strong correlation between the PR3 and HLE concentrations (rs = 0.898, p \u3c 1 × 10–6 ). Importantly, PR3 hydrolyzed fluorescently labeled collagen II as efficiently as HLE. Taken together, these novel findings suggest that PR3 (in addition to HLE) contributes to JIA-associated joint damage

The Structure of the Vortex Liquid at the Surface of a Layered Superconductor

A density-functional approach is used to calculate the inhomogeneous vortex density distribution in the flux liquid phase at the planar surface of a layered superconductor, where the external magnetic field is perpendicular to the superconducting layers and parallel to the surface. The interactions with image vortices are treated within a mean field approximation as a functional of the vortex density. Near the freezing transition strong vortex density fluctuations are found to persist far into the bulk liquid. We also calculate the height of the Bean-Livingston surface barrier.Comment: 8 pages, RevTeX, 2 figure

Berry effect in acoustical polarization transport in phononic crystals

We derive the semiclassical equations of motion of a transverse acoustical wave packet propagating in a phononic crystal subject to slowly varying perturbations. The formalism gives rise to Berry effect terms in the equations of motion, manifested as the Rytov polarization rotation law and the polarization-dependent Hall effect. We show that the formalism is also applicable to the case of non-periodic inhomogeneous media, yielding explicit expressions for the Berry effect terms.Comment: To appear in JETP Let

Dendritic cells loaded with killed breast cancer cells induce differentiation of tumor-specific cytotoxic T lymphocytes

BACKGROUND: Early clinical trials, mostly in the setting of melanoma, have shown that dendritic cells (DCs) expressing tumor antigens induce some immune responses and some clinical responses. A major difficulty is the extension to other tumors, such as breast carcinoma, for which few defined tumor-associated antigens are available. We have demonstrated, using both prostate carcinoma and melanoma as model systems, that DCs loaded with killed allogeneic tumor cell lines can induce CD8(+ )T cells to differentiate into cytotoxic T lymphocytes (CTLs) specific for shared tumor antigens. METHODS: The present study was designed to determine whether DCs would capture killed breast cancer cells and present their antigens to autologous CD4(+ )and CD8(+ )T cells. RESULTS: We show that killed breast cancer cells are captured by immature DCs that, after induced maturation, can efficiently present MHC class I and class II peptides to CD8(+ )and CD4(+ )T lymphocytes. The elicited CTLs are able to kill the target cells without a need for pretreatment with interferon gamma. CTLs can be obtained by culturing the DCs loaded with killed breast cancer cells with unseparated peripheral blood lymphocytes, indicating that the DCs can overcome any potential inhibitory effects of breast cancer cells. CONCLUSION: Loading DCs with killed breast cancer cells may be considered a novel approach to breast cancer immunotherapy and to identification of shared breast cancer antigens

Computing CMB Anisotropy in Compact Hyperbolic Spaces

The measurements of CMB anisotropy have opened up a window for probing the global topology of the universe on length scales comparable to and beyond the Hubble radius. For compact topologies, the two main effects on the CMB are: (1) the breaking of statistical isotropy in characteristic patterns determined by the photon geodesic structure of the manifold and (2) an infrared cutoff in the power spectrum of perturbations imposed by the finite spatial extent. We present a completely general scheme using the regularized method of images for calculating CMB anisotropy in models with nontrivial topology, and apply it to the computationally challenging compact hyperbolic topologies. This new technique eliminates the need for the difficult task of spatial eigenmode decomposition on these spaces. We estimate a Bayesian probability for a selection of models by confronting the theoretical pixel-pixel temperature correlation function with the COBE-DMR data. Our results demonstrate that strong constraints on compactness arise: if the universe is small compared to the `horizon' size, correlations appear in the maps that are irreconcilable with the observations. If the universe is of comparable size, the likelihood function is very dependent upon orientation of the manifold wrt the sky. While most orientations may be strongly ruled out, it sometimes happens that for a specific orientation the predicted correlation patterns are preferred over the conventional infinite models.Comment: 15 pages, LaTeX (IOP style included), 3 color figures (GIF) in separate files. Minor revision to match the version accepted in Class. Quantum Grav.: Proc. of Topology and Cosmology, Cleveland, 1997. The paper can be also downloaded from http://www.cita.utoronto.ca/~pogosyan/cwru_proc.ps.g

Electromagnetic Form Factors of the Nucleon in an Improved Quark Model

Nucleon electromagnetic form factors are studied in the cloudy bag model (CBM) with center-of-mass and recoil corrections. This is the first presentation of a full set of nucleon form factors using the CBM. The center of mass motion is eliminated via several different momentum projection techniques and the results are compared. It is found that the shapes of these form factors are significantly improved with respect to the experimental data if the Lorentz contraction of the internal structure of the baryon is also appropriately taken into account.Comment: revtex, 28 pages, 8 ps figs include