SimFusion: A Unified Similarity Measurement Algorithm for Multi-Type Interrelated Web Objects

In this paper, we use a Unified Relationship Matrix (URM) to represent a set of heterogeneous web objects (e.g., web pages, queries) and their interrelationships (e.g., hyperlink, user click-through relationships). We claim that iterative computations over the URM can help overcome the data sparseness problem (a common situation in the Web) and detect latent relationships among heterogeneous web objects, thus, can improve the quality of various information applications that require the combination of information from heterogeneous sources. To support our claim, we further propose a unified similarity-calculating algorithm, the SimFusion algorithm. By iteratively computing over the URM, the SimFusion algorithm can effectively integrate relationships from heterogeneous sources when measuring the similarity of two web objects. Experiments based on a real search engine query log and a large real web page collection demonstrate that the SimFusion algorithm can significantly improve similarity measurement of web objects over both traditional content based similarity-calculating algorithms and the cutting edge SimRank algorithm

Research on algorithm of borehole resistivity imaging method

Tradicionalna metoda istraživanja istosmjerne struje suočit će se s velikim izazovom kad se otkrije duboki, složeni geološki cilj. U tu svrhuje razvijena je metoda unaprijednog modeliranja i inverznog modeliranja otpora bušotine. U skladu s geološkim značajkama, postavljen je geološki model. Numerička simulacija pokazuje da je metoda otpora bušotine vrlo dubok, složen geo-model. Stoga ovo istraživanje daje novu ideju za istraživanje dubokog, složenog cilja geo-električnog modela.Traditional dc electrical exploration method will face great challenge when detecting deep, complex geologic target. With the purpose, forward modelling and inverse modelling method of borehole resistivity has been developed. According to the characters of geology, the geological model has been set up. The numerical simulation shows that borehole resistivity method is a very deep, complex geo-model. Therefore, this research provides a new idea for exploring deep, complex target of geo-electrical model

VPA mediates bidirectional regulation of cell cycle progression through the PPP2R2A-Chk1 signaling axis in response to HU

Cell cycle checkpoint kinases play a pivotal role in protecting against replicative stress. In this study, valproic acid (VPA), a histone deacetylase inhibitor (HDACi), was found to promote breast cancer MCF-7 cells to traverse into G2/M phase for catastrophic injury by promoting PPP2R2A (the B-regulatory subunit of Phosphatase PP2A) to facilitate the dephosphorylation of Chk1 at Ser317 and Ser345. By contrast, VPA protected normal 16HBE cells from HU toxicity through decreasing PPP2R2A expression and increasing Chk1 phosphorylation. The effect of VPA on PPP2R2A was at the post-transcription level through HDAC1/2. The in vitro results were affirmed in vivo. Patients with lower PPP2R2A expression and higher pChk1 expression showed significantly worse survival. PPP2R2A D197 and N181 are essential for PPP2R2A-Chk1 signaling and VPA-mediated bidirectional effect on augmenting HU-induced tumor cell death and protecting normal cells

Modeling of whole-space transient electromagnetic responses based on FDTD and its application in the mining industry

Hidden, water-abundant areas in coal mines pose a serious threat to mine safety and production. Underground transient electromagnetic method (TEM) is one of the most effective means of detecting water-abundant areas in front of the roadway head. Traditional TEM theories and applications are interpreted mainly on the vertical component. In this study, multicomponent responses of TEM in underground roadways were modeled using the finite-difference time-domain method. Physical simulation was also used for advanced detection of TEM in the roadway. Both the numerical and physical simulation results show that the horizontal component is more sensitive to the location of water-abundant areas. The results of the joint interpretation with both horizontal and vertical components were verified in a practical coal mine application, indicating that it is feasible to use the horizontal component in interpreting TEM data. Thus, the horizontal component could serve as a new approach for coal mine TEM data processing and interpretation.The State Key Research Development Program of China (NO. 2017YFC0804401), in part by the China Postdoctoral Science Foundation (NO.110101/3445), and in part by the National Research Foundation, South Africa (RDYR160404161474).http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=9424hj2018Electrical, Electronic and Computer Engineerin

Paradoxical Association of C-Reactive Protein with Endothelial Function in Rheumatoid Arthritis

Background: Within the general population, levels of C-reactive protein (CRP) are positively associated with atherosclerotic cardiovascular disease (CVD). Whether CRP is causally implicated in atherogenesis or is the results of atherosclerosis is disputed. A role of CRP to protect endothelium-derived nitric oxide (EDNO) has been suggested. We examined the association of CRP with EDNO-dependent vasomotor function and subclinical measures of atherosclerosis and arteriosclerosis in patients with raised CRP resulting from rheumatoid arthritis (RA).Methodology/Principal Findings: Patients with RA (n = 59) and healthy control subjects (n = 123), underwent measures of high sensitivity CRP, flow-mediated dilation (FMD, dependent on EDNO), intima-media thickness (IMT, a measure of subclinical atherosclerosis) and aortic pulse wave velocity (PWV, a measure of arteriosclerosis). IMT and PWV were elevated in patients with RA compared to controls but FMD was similar in the two groups. In patients with RA, IMT and PWV were not correlated with CRP but FMD was positively independently correlated with CRP (P<0.01).Conclusions/Significance: These findings argue against a causal role of CRP in atherogenesis and are consistent with a protective effect of CRP on EDNO bioavailability

Analysis of malnutrition of preschool children from Zhag’yab County in Tibet

Objective To investigate physical development level of preschool children from Zhag’yab County in Tibet，aiming to provide reference for improving the nutritional status of children in this region. Methods In this cross-sectional study，the height and weight of children aged 3-6 years old from Zhag’yab County in Tibet were measured. The nutritional status was evaluated according to the WHO child growth standards. Results The overall prevalence rates of malnutrition， stunting， underweight and wasting were 22.6%， 13.0%， 10.9% and 10.0%， respectively. The differences between urban and rural areas were statistically significant （all P &lt;0.05）. No statistical significance was observed among different age groups （all P &gt; 0.05）. Conclusion In Zhag’yab County， the physical development level of preschool children is poor and the malnutrition rate is relatively high. Significant difference can be noted between urban and rural areas. Extensive attention should be paid to scientific feeding and children health，especially in rural area

Risk factors associated with postoperative respiratory failure after esophagectomy for esophageal cancer

Aim: Respiratory failure is common after esophagectomy for esophageal cancer (EC). This study aimed to identify the risk factors associated with postoperative respiratory failure following esophagectomy for EC. Methods: A single-center observational study from China was conducted on 262 patients with EC who underwent thoracoscopic esophagectomy between April 2014 and June 2016. The patients were divided into two groups: group I (respiratory failure) and group II (without respiratory failure). Demographic and perioperative variables, tumor-related factors, surgical factors, Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, and clinical course were compared between the groups. Univariable and multivariable logistic regression analyses were performed to assess the risk factors of postoperative respiratory failure after esophagectomy. Results: Among the 262 patients, 24 (9.2%) developed respiratory failure. Univariable analysis revealed several risk factors, including age, smoking, comorbidities, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), forced vital capacity (FVC), FVC percentage (FVC%), urine volume during surgery, and APACHE II score. Multivariable analysis showed that age, comorbidities of diabetes mellitus (DM), FVC%, urine volume during surgery, and APACHE II score were independent predictors of respiratory failure. Specifically, elderly patients (> 65 years) with comorbidities of DM, lower FVC%, higher urine volume during surgery, and elevated APACHE II score were found to be more susceptible to respiratory failure, resulting in prolonged hospitalization and increased healthcare burden. These findings emphasize the importance of considering these factors in the management and care of patients at risk of respiratory failure. Conclusions: As a common complication following esophagectomy for EC. Respiratory failure is significantly associated with age, comorbidities of DM, FVC%, urine volume during surgery, and APACHE II score in the dataset. The findings will contribute to the evaluation of the risk of respiratory failure and guide early intervention strategies in clinical decision-making