1 research outputs found
Antiadhesive Properties of Glycoclusters against <i>Pseudomonas aeruginosa</i> Lung Infection
<i>Pseudomonas aeruginosa</i> lung infections are a major
cause of death in cystic fibrosis and hospitalized patients. Treating
these infections is becoming difficult due to the emergence of conventional
antimicrobial multiresistance. While monosaccharides have proved beneficial
against such bacterial lung infection, the design of several multivalent
glycosylated macromolecules has been shown to be also beneficial on
biofilm dispersion. In this study, calix[4]arene-based glycoclusters
functionalized with galactosides or fucosides have been synthesized.
The characterization of their inhibitory properties on <i>Pseudomonas
aeruginosa</i> aggregation, biofilm formation, adhesion on epithelial
cells, and destruction of alveolar tissues were performed. The antiadhesive
properties of the designed glycoclusters were demonstrated through
several in vitro bioassays. An in vivo mouse model of lung infection
provided an almost complete protection against <i>Pseudomonas
aeruginosa</i> with the designed glycoclusters