Automated left ventricular diastolic function evaluation from phase-contrast cardiovascular magnetic resonance and comparison with Doppler echocardiography

International audienceBACKGROUND: Early detection of diastolic dysfunction is crucial for patients with incipient heart failure. Although this evaluation could be performed from phase-contrast (PC) cardiovascular magnetic resonance (CMR) data, its usefulness in clinical routine is not yet established, mainly because the interpretation of such data remains mostly based on manual post-processing. Accordingly, our goal was to develop a robust process to automatically estimate velocity and flow rate-related diastolic parameters from PC-CMR data and to test the consistency of these parameters against echocardiography as well as their ability to characterize left ventricular (LV) diastolic dysfunction. RESULTS: We studied 35 controls and 18 patients with severe aortic valve stenosis and preserved LV ejection fraction who had PC-CMR and Doppler echocardiography exams on the same day. PC-CMR mitral flow and myocardial velocity data were analyzed using custom software for semi-automated extraction of diastolic parameters. Inter-operator reproducibility of flow pattern segmentation and functional parameters was assessed on a sub-group of 30 subjects. The mean percentage of overlap between the transmitral flow segmentations performed by two independent operators was 99.7 ± 1.6%, resulting in a small variability ( 0.71) and receiver operating characteristic (ROC) analysis revealed their ability to separate patients from controls, with sensitivity > 0.80, specificity > 0.80 and accuracy > 0.85. Slight superiority in terms of correlation with echocardiography (r = 0.81) and accuracy to detect LV abnormalities (sensitivity > 0.83, specificity > 0.91 and accuracy > 0.89) was found for the PC-CMR flow-rate related parameters. CONCLUSIONS: A fast and reproducible technique for flow and myocardial PC-CMR data analysis was successfully used on controls and patients to extract consistent velocity-related diastolic parameters, as well as flow rate-related parameters. This technique provides a valuable addition to established CMR tools in the evaluation and the management of patients with diastolic dysfunction

Analyse de la contraction myocardique longitudinale dans l'hypertension artérielle avec fraction d'éjection normale

PARIS7-Xavier Bichat (751182101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

ASYNCHRONISME INTERVENTRICULAIRE (CORRELATION ENTRE ECHOGRAPHIE ET SCINTIGRAPHIE ; VARIATION DES INDICES ECHOGRAPHIQUES EN FONCTION DE LA VOLEMIE)

PARIS7-Villemin (751102101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Lymphangiome kystique intrapéricardique (à propos d'une observation et revue de la littérature)

PARIS7-Xavier Bichat (751182101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Méthodes de traitement d'images pour l'étude fonctionnelle du ventricule gauche (application en échocardiographie et en IRM)

Résumé françaisRésumé anglaisORSAY-PARIS 11-BU Sciences (914712101) / SudocSudocFranceF

Facteurs échographiques associés à un niveau de BNP élevé chez les insuffisants cardiaques (interaction systole diastole)

PARIS6-Bibl.Pitié-Salpêtrie (751132101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Evaluation du scanner cardiaque multiphases dans l insuffisance mitrale (corrélations anatomiques et fonctionnelles avec l échocardiographie et étude d une approche optimisée de son interprétation)

PARIS7-Xavier Bichat (751182101) / SudocSudocFranceF

Cardiomyopathie de Fabry en échocardiographie et en imagerie par résonance magnétique (Apport du doppler tissulaire pour la détection de l'atteinte cardiaque et de la fibrose myocardique)

LE KREMLIN-B.- PARIS 11-BU Méd (940432101) / SudocSudocFranceF