80,421 research outputs found
Letter from Moses F. Shim to James B. Finley
Rev. Shim, a member of the Iowa M.E. Conference, writes on behalf of one Jacob Bennett, son of Joseph Bennett. Jacob needs to prove that he was not an inmate at the Ohio Penitentiary from 1827 to 1836. Shim would like Finley to research this name. If found, Shim would like information from Finley about the prisoner\u27s size, complexion, etc., in order to prove that the Jacob Bennett in Iowa is not the person who was incarcerated in Ohio. Abstract Number - 1061https://digitalcommons.owu.edu/finley-letters/2045/thumbnail.jp
Recent Books of Interest to Teachers
Bennett and Haniphy\u27s Historical Readings -John W. Wayland; Atwood\u27s Civic and Economic Biology - George W. Chappelear, Jr; Worst\u27s Construction Work for the Primary Grades -M.E. Cornell; Cohen\u27s Longer Plays by Modern Authors - Ruth S. Hudson; Jenkin\u27s The Perfect Gentle Knight - P.P. Moody; Changes in the Cost of Living, July, 1914, to November, 1921 - Grace Brinto
CO 610 Ethical and Legal Issues in Counseling
Herlihy, B. & Corey, G., (1996). ACA ethical standards casebook. American Counseling Association, Alexandria, VA. (326 pages) Sanders, Randolph K., (1997). Christian counseling ethics: A handbook for therapists, pastors and counselors, Intervarsity Press, Downers Grove, IL. (404 pages) Moline, M.E., Williams, G.T., & Austin, K.M., (1998). Documenting psychotherapy: Essentials for mental health practitioners. Sage, London. (189 pages) _____, (1998). AACC Christian counseling code of ethics. American Association of Christian Counseling, Forest, VA. (20 pages) available to down load at [ http://www.AACC.net ]www.AACC.net Bennett, B.E., et. al., (1990). Professional liability and risk management. American Psychological Association, Washington, D.C.. (128 pages) Nagy, T.E., (2000). Ethics in plain English: An illustrative textbook for psychologists. American Psychological Association, Washington, D.C.. (260 pages)https://place.asburyseminary.edu/syllabi/3338/thumbnail.jp
CO 610 Ethical and Legal Issues in Counseling
Required Readings Herlihy, B. & Corey, G., (1996). ACA ethical standards casebook. American Counseling Association, Alexandria, VA. (326 pages) Sanders, Randolph K., (1997). Christian counseling ethics: A handbook for therapists, pastors and counselors, Intervarsity Press, Downers Grove, IL. (404 pages) Moline, M.E., Williams, G.T., & Austin, K.M., (1998). Documenting psychotherapy: Essentials for mental health practitioners. Sage, London. (189 pages) _____, (1998). AACC Christian counseling code of ethics. American Association of Christian Counseling, Forest, VA. (20 pages) available to down load at www.AACC.net Bennett, B.E., et. al., (1990). Professional liability and risk management. American Psychological Association, Washington, D.C.. (128 pages) Nagy, T.E., (2000). Ethics in plain English: An illustrative textbook for psychologists. American Psychological Association, Washington, D.C.. (260 pages) ------, (2005) Reading Packet, available from the bookstore (100 pages)https://place.asburyseminary.edu/syllabi/2380/thumbnail.jp
Scallop swimming kinematics and muscle performance: modelling the effects of "within-animal" variation in temperature sensitivity
Escape behaviour was investigated in Queen scallops (Aequipecten opercularis) acclimated to 5, 10 or 15 degrees C and tested at their acclimation temperature. Scallops are active molluscs, able to escape from predators by jet-propelled swimming using a striated muscle working in opposition to an elastic hinge ligament. The first cycle of the escape response was recorded using high-speed video ( 250 Hz) and whole-animal velocity and acceleration determined. Muscle shortening velocity, force and power output were calculated using measurements of valve movement and jet area, and a simple biomechanical model. The average shortening speed of the adductor muscle had a Q(10) of 2.04, significantly reducing the duration of the jetting phase of the cycle with increased temperature. Muscle lengthening velocity and the overall duration of the clap cycle were changed little over the range 5 - 15 degrees C, as these parameters were controlled by the relatively temperature-insensitive, hinge ligament. Improvements in the average power output of the adductor muscle over the first clap cycle ( 222 vs. 139 W kg(-1) wet mass at 15 and 5 degrees C respectively) were not translated into proportional increases in overall swimming velocity, which was only 32% higher at 15 degrees C ( 0.37m s(-1)) than 5 degrees C (0.28 m s(-1))
Inhibition of the Aminopeptidase from \u3cem\u3eAeromonas proteolytica\u3c/em\u3e by l-leucinethiol: Kinetic and Spectroscopic Characterization of a Slow, Tight-binding Inhibitorβenzyme Complex
The peptide inhibitor l-leucinethiol (LeuSH) was found to be a potent, slow-binding inhibitor of the aminopeptidase from Aeromonas proteolytica (AAP). The overall potency (KI*) of LeuSH was 7 nM while the corresponding alcohol l-leucinol (LeuOH) was a simple competitive inhibitor of much lower potency (KI=17 ΞΌM). These data suggest that the free thiol is likely involved in the formation of the EΒ·I and EΒ·I* complexes, presumably providing a metal ligand. In order to probe the nature of the interaction of LeuSH and LeuOH with the dinuclear active site of AAP, we have recorded both the electronic absorption and EPR spectra of [CoCo(AAP)], [CoZn(AAP)], and [ZnCo(AAP)] in the presence of both inhibitors. In the presence of LeuSH, all three Co(II)-substituted AAP enzymes exhibited an absorption band centered at 295 nm, characteristic of a SβCo(II) ligand-metal charge-transfer band. In addition, absorption spectra recorded in the 450 to 700 nm region all showed changes characteristic of LeuSH and LeuOH interacting with both metal ions. EPR spectra recorded at high temperature (19 K) and low power (2.5 mW) indicated that, in a given enzyme molecule, LeuSH interacts weakly with one of the metal ions in the dinuclear site and that the crystallographically identified ΞΌ-OH(H) bridge, which has been shown to mediate electronic interaction of the Co(II) ions, is likely broken upon binding LeuSH. EPR spectra of [CoCo(AAP)]-LeuSH, [ZnCo(AAP)]-LeuSH, and [Co_(AAP)]-LeuSH were also recorded at lower temperature (3.5β4.0 K) and high microwave power (50β553 mW). These signals were unusual and appeared to contain, in addition to the incompletely saturated contributions from the signals characterized at 19 K, a very sharp feature at geffβΌ6.5 that is characteristic of thiolate-Co(II) interactions. Combination of the electronic absorption and EPR data indicates that LeuSH perturbs the electronic structure of both metal ions in the dinuclear active site of AAP. Since the spinβspin interaction seen in resting [CoCo(AAP)] is abolished upon the addition of LeuSH, it is unlikely that a ΞΌ-S(R) bridge is established
The ubiquitin-proteasome pathway in Huntington's disease.
The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity. Accompanying neuronal death, mutant huntingtin aggregates in large macromolecular structures called inclusion bodies. The function of the machinery for intracellular protein degradation is linked to huntingtin toxicity and components of this machinery colocalize with inclusion bodies. An increasing body of evidence implicates the ubiquitin-proteasome pathway in the failure of cells to degrade mutant huntingtin. A number of potential mechanisms that link compromised ubiquitin-proteasome pathway function and neurodegeneration have been proposed and may offer opportunities for therapeutic intervention
Recommended from our members
Ecological thresholds and large carnivores conservation: Implications for the Amur tiger and leopard in China
The ecological threshold concept describes how changes in one or more factors at thresholds can result in a large shift in the state of an ecosystem. This concept focuses attention on limiting factors that affect the tolerance of systems or organisms and changes in them. Accumulating empirical evidence for the existence of ecological thresholds has created favorable conditions for practical application to wildlife conservation. Applying the concept has the potential to enhance conservation of two large carnivores, Amur tiger and leopard, and the knowledge gained could guide the construction of a proposed national park. In this review, ecological thresholds that result from considering a paradigm of bottom-up control were evaluated for their potential to contribute to the conservation of Amur tiger and leopard. Our review highlights that large carnivores, as top predators, are potentially affected by ecological thresholds arising from changes in climate (or weather), habitat, vegetation, prey, competitors, and anthropogenic disturbances. What's more, interactions between factors and context dependence need to be considered in threshold research and conservation practice, because they may amplify the response of ecosystems or organisms to changes in specific drivers. Application of the threshold concept leads to a more thorough evaluation of conservation needs, and could be used to guide future Amur tiger and leopard research and conservation in China. Such application may inform the conservation of other large carnivores worldwide
Recommended from our members
Batrachoseps attenuatus
Number of Pages: 6Integrative BiologyGeological Science
- β¦