Measurements of Differential Reflectivity in Snowstorms and Warm Season Stratiform Systems

The organized behavior of differential radar reflectivity (ZDR) is documented in the cold regions of a wide variety of stratiform precipitation types occurring in both winter and summer. The radar targets and attendant cloud microphysical conditions are interpreted within the context of measurements of ice crystal types in laboratory diffusion chambers in which humidity and temperature are both stringently controlled. The overriding operational interest here is in the identification of regions prone to icing hazards with long horizontal paths. Two predominant regimes are identified: category A, which is typified by moderate reflectivity (from 10 to 30 dBZ) and modest +ZDR values (from 0 to +3 dB) in which both supercooled water and dendritic ice crystals (and oriented aggregates of ice crystals) are present at a mean temperature of −13°C, and category B, which is typified by small reflectivity (from −10 to +10 dBZ) and the largest +ZDR values (from +3 to +7 dB), in which supercooled water is dilute or absent and both flat-plate and dendritic crystals are likely. The predominant positive values for ZDR in many case studies suggest that the role of an electric field on ice particle orientation is small in comparison with gravity. The absence of robust +ZDR signatures in the trailing stratiform regions of vigorous summer squall lines may be due both to the infusion of noncrystalline ice particles (i.e., graupel and rimed aggregates) from the leading deep convection and to the effects of the stronger electric fields expected in these situations. These polarimetric measurements and their interpretations underscore the need for the accurate calibration of ZDR.United States. Federal Aviation Administration (Air Force Contract FA8721-05-C-0002

Research Priorities to Support Effective Manta and Devil Ray Conservation

Manta and devil rays are filter-feeding elasmobranchs that are found circumglobally in tropical and subtropical waters. Although relatively understudied for most of the Twentieth century, public awareness and scientific research on these species has increased dramatically in recent years. Much of this attention has been in response to targeted fisheries, international trade in mobulid products, and a growing concern over the fate of exploited populations. Despite progress in mobulid research, major knowledge gaps still exist, hindering the development of effective management and conservation strategies. We assembled 30 leaders and emerging experts in the fields of mobulid biology, ecology, and conservation to identify pressing knowledge gaps that must be filled to facilitate improved science-based management of these vulnerable species. We highlight focal research topics in the subject areas of taxonomy and diversity, life history, reproduction and nursery areas, population trends, bycatch and fisheries, spatial dynamics and movements, foraging and diving, pollution and contaminants, and sub-lethal impacts. Mobulid rays remain a poorly studied group, and therefore our list of important knowledge gaps is extensive. However, we hope that this identification of high priority knowledge gaps will stimulate and focus future mobulid research

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Introduction: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. Methods: In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025. Findings: Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation. Interpretation: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification

Gestation and size at parturition for Mobula kuhlii cf. eregoodootenkee

Few data are available describing reproduction in the pygmy devilray, Mobula kuhlii cf. eregoodootenkee, or mobulids in general. Using samples collected from bather-protection gillnets deployed off eastern Australia during 2017–18 we provide further comment on their periodicity, gestation and size at parturition. Twelve adult specimens were necropsied: two were males (99.5 and 106.3\ua0cm disc width–DW); five were pre-ovulatory (112.4–122.0\ua0cm DW) non-gravid females with 15–25 oocytes in their functional left ovary; and five were gravid (112.6–121.0\ua0cm DW), each with a single embryo (24.0–42.3\ua0cm DW) but similar numbers and sizes of ovarian follicles as their non-gravid conspecifics. At 43.2\ua0cm DW or 36% of its mother’s DW, the largest embryo was almost full term. Considering previous data describing early pregnancies, reproduction appears seasonal (but not consecutive) and involves protracted mating and a gestation probably >12 mo. The data reiterate a low reproductive output and a need for appropriate conservation strategies