35 research outputs found
Spin fluctuations in the quasi-two dimensional Heisenberg ferromagnet GdI_2 studied by Electron Spin Resonance
The spin dynamics of GdI_2 have been investigated by ESR spectroscopy. The
temperature dependences of the resonance field and ESR intensity are well
described by the model for the spin susceptibility proposed by Eremin et al.
[Phys. Rev. B 64, 064425 (2001)]. The temperature dependence of the resonance
linewidth shows a maximum similar to the electrical resistance and is discussed
in terms of scattering processes between conduction electrons and localized
spins.Comment: to be published in PR
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
Genome-wide association analyses identify 123 susceptibility loci for migraine and implicate neurovascular mechanisms in its pathophysiology. Subtype analyses highlight risk loci specific for migraine with or without aura in addition to shared risk variants.Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that seem specific for migraine without aura (near SPINK2 and near FECH) and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide (CALCA/CALCB) and serotonin 1F receptor (HTR1F). Overall, genomic annotations among migraine-associated variants were enriched in both vascular and central nervous system tissue/cell types, supporting unequivocally that neurovascular mechanisms underlie migraine pathophysiology.Clinical epidemiolog
Fluvastatin and perioperative events in patients undergoing vascular surgery
BACKGROUND: Adverse cardiac events are common after vascular surgery. We hypothesized that perioperative statin therapy would improve postoperative outcomes. METHODS: In this double-blind, placebo-co