MiRNA deregulation targets specific pathways in leiomyosarcoma development: An in silico analysis

BackgroundMicroRNA (miRNA) mediate post-transcriptional gene repression and are involved in a variety of human diseases, including cancer. Soft tissue sarcomas are rare malignancies with a variety of histological subtypes which may occur virtually anywhere in the human body. Leiomyosarcoma is one of the most common subtypes, shows a smooth muscle phenotype and its cancerogenesis is still unclear. The aim of our study was to investigate the potential role of miRNA differential expression in leiomyosarcoma development.MethodsWe first employed the Sarcoma microRNA Expression Database, a repository that describes the patterns of over 1000 miRNA expression in various human sarcoma types, to identify differentially expressed miRNA comparing leiomyosarcoma and smooth muscle samples. Subsequently, we identified putative target genes of those miRNAs with the TargetScan prediction tool. Finally, we evaluated whether the retrieved pool of putative targets was enriched in genes belonging to specific molecular pathways by means of the Enrichr analysis tool. Protein-protein network analysis was analyzed by means of the STRING web tool.ResultsOut of 1120 miRNAs tested, the expression of 301 miRNAs was statistically significantly different between leiomyosarcoma and smooth muscle samples. The hypothetical targets could be predicted for 172 miRNAs. 438 genes were predicted to be the targets with high confidence (cumulative weighted context score cut-off level less than -1.0) and analyzed for belonging to specific molecular pathways. Pathway analysis suggested that RNA Polymerase III, tRNA functions and synaptic neurotransmission (with special regard to dopamine mediated signaling) could be involved in leiomyosarcoma development.ConclusionsOur results demonstrate that data mining of publicly available repositories can be useful to suggest molecular pathways underlying the pathogenesis of rare tumors such as leiomyosarcoma

Perturbing Around A Warped Product Of AdS_4 and Seven-Ellipsoid

We compute the spin-2 Kaluza-Klein modes around a warped product of AdS_4 and a seven-ellipsoid. This background with global G_2 symmetry is related to a U(N) x U(N) N=1 superconformal Chern-Simons matter theory with sixth order superpotential. The mass-squared in AdS_4 is quadratic in G_2 quantum number and KK excitation number. We determine the dimensions of spin-2 operators using the AdS/CFT correspondence. The connection to N=2 theory preserving SU(3) x U(1)_R is also discussed.Comment: 21pp; The second and last paragraphs of section 2, the footnotes 1 and 2 added and to appear in JHE

Notes on Supersymmetry Enhancement of ABJM Theory

We study the supersymmetry enhancement of ABJM theory. Starting from a ${\cal N}=2$ supersymmetric Chern-Simons matter theory with gauge group U(2)$\times$U(2) which is a truncated version of the ABJM theory, we find by using the monopole operator that there is additional ${\cal N}=2$ supersymmetry related to the gauge group. We show this additional supersymmetry can combine with ${\cal N}=6$ supersymmetry of the original ABJM theory to an enhanced ${\cal N}=8$ SUSY with gauge group U(2)$\times$U(2) in the case $k=1,2$. We also discuss the supersymmetry enhancement of the ABJM theory with U($N$)$\times$U($N$) gauge group and find a condition which should be satisfied by the monopole operator.Comment: 23 pages, no figure, minor corrections, version to appear in JHE

A New and Elementary CP^n Dyonic Magnon

We show that the dressing transformation method produces a new type of dyonic CP^n magnon in terms of which all the other known solutions are either composites or arise as special limits. In particular, this includes the embedding of Dorey's dyonic magnon via an RP^3 subspace of CP^n. We also show how to generate Dorey's dyonic magnon directly in the S^n sigma model via the dressing method without resorting to the isomorphism with the SU(2) principle chiral model when n=3. The new dyon is shown to be either a charged dyon or topological kink of the related symmetric-space sine-Gordon theories associated to CP^n and in this sense is a direct generalization of the soliton of the complex sine-Gordon theory.Comment: 21 pages, JHEP3, typos correcte