Significant cytokines at different phases of illness when compared to the controls.

<p>Significant cytokines at different phases of illness when compared to the controls.</p

IFN-γ T cell responses in the study population.

<p>(A) SFC per million PBMCs of patients with (red) and without (blue) warning signs in response to pooled peptide. The mean cutoff values after subtraction of healthy control is at 770SFC/million PBMCs. Mean ± SEM is given for every peptide pool. (B) Number of responders towards each peptide pool for patients with (red) and without (blue) warning signs is given in percentage. (C) SFC per million PBMCs of patients in response to individual peptides. The mean cutoff values after subtraction of healthy control is not given as it varied for every peptide. The mean response for each peptide is indicated in the mean line. Table below graph shows each individual peptide, and the number of responders towards these peptides.</p

Clinical profile of study population.

<p>Scatter plot of the study population’s (A) vital signs (temperature, systolic, diastolic and pulse rate); (B) blood profile (hemoglobin, hematocrit, platelet, prothrombin time, activated partial thromboplastin time); (C) white blood cell profile (total white blood cells, lymphocytes, neutrophils and monocytes); (D) liver profile (total protein, total billirubin, albumin, globulin, alkaline phosphatase, alanine transaminase, aspartate aminotransferase) and (E) kidney profile (urea, sodium, potassium, chloride and creatinine) over days of illness. The LOWESS curves follows the general trend of the observed clinical parameter in dengue patients without (blue) and with (red) warning signs. Grey zone shows the reference range values.</p

Demographics on study population based on clinical diagnosis.

<p>ND: Non dengue; DwoWS: Dengue without warning signs; DwWS: Dengue with warning signs; SD: Severe dengue; SEM: Standard error mean;</p>a<p>Discharged with the respective classification and with hepatitis;</p>b<p>Previous known dengue infections to the knowledge of the patient.</p

HLA association with dengue of the study population.

<p>HLA association with dengue of the study population.</p

Clinical symptoms of the study population.

<p>*indicates the symptoms/manifestations considered as warning signs by the WHO 2009 dengue classification. Detailed clinical symptoms (in percentages) by dengue classification are given in the table.</p

HLA Allele Frequencies in the Study Population.

<p>(A) HLA-A alleles in the total study population; (B) HLA-B alleles in the total study population.</p

Laboratory diagnostics confirmation of study population.

<p>ND: Non dengue; DwoWS: Dengue without warning signs; DwWS: Dengue with warning signs; SD: Severe dengue; IgM: Immunoglobulin M; NS1: Non-structural protein 1; HI: Hemagglutination Inhibiton Assay; +: combination.</p

Hospital laboratory diagnostics specifically Dengue IgM and Dengue NS1.

<p>ND: Non dengue; DwoWS: Dengue without warning signs; DwWS: Dengue with warning signs; SD: Severe dengue; IgM: Immunoglobulin M; NS1: Non-structural protein 1; −ve: negative; +ve: positive; ND: not determined;</p>a<p>IgM ELISA done in the hospital laboratory;</p>b<p>NS1 ELISA done in the hospital laboratory.</p