6 research outputs found
Do Company Builders Create Jobs? Examining the Rise of Incubation Finance in Germany
- Author
- /Perep Investeurope
- Alex Hofmann
- Andree Engelmann
- Ann-Kristin Achleitner
- Ann-Kristin Achleitner
- Anne B�llingtoft
- Ansgar Belke
- Attila Szigeti
- Attila Szigeti
- Barbero
- Ben Rooney
- Benjamin Heimlich
- Christian Rammer
- Christoph Scheuplein
- Christoph Scheuplein
- Da Rin
- David Allen
- David S Evans
- Dieter Urban
- Dirk Engel
- Eduardo Salido
- Eric Stokan
- Fabio Bertoni
- Fabio Bertoni
- Holger Garbs
- Horst Feldmann
- Huseyin Leblebici
- Joel Kaczmarek
- Johan Bruneel
- Julian Kahl
- Julian Kahl
- Julian M Kawohl
- Klaus - R�hl
- Leena Rao
- Malte Brettel
- Marianne Kulicke
- Matthew M C Allen
- Michael Kroker
- Mirko Bendig
- Morten Hansen
- Nadine Schimroszik
- Nicola Dee
- Otto Keck
- Paul Miller
- Peter Witt
- Phillip H Phan
- Rosa Grimaldi
- Rudy Aernoudt
- Sarfraz Mian
- Sean M Hackett
- Ulrich Schmoch
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Equity in the distribution of urban environmental amenities: the case of Washington, D.C.
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets
- Author
- Publication venue
- American Society of Hematology
- Publication date
- 01/01/2023
- Field of study
Clonal hematopoiesis of indeterminate potential (CHIP) is a common form of age-related somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations can be identified in peripheral blood samples that are sequenced using approaches that cover the whole genome, the whole exome, or targeted genetic regions; however, differentiating true CHIP mutations from sequencing artifacts and germ line variants is a considerable bioinformatic challenge. We present a stepwise method that combines filtering based on sequencing metrics, variant annotation, and population-based associations to increase the accuracy of CHIP calls. We apply this approach to ascertain CHIP in ∼550 000 individuals in the UK Biobank complete whole exome cohort and the All of Us Research Program initial whole genome release cohort. CHIP ascertainment on this scale unmasks recurrent artifactual variants and highlights the importance of specialized filtering approaches for several genes, including TET2 and ASXL1. We show how small changes in filtering parameters can considerably increase CHIP misclassification and reduce the effect size of epidemiological associations. Our high-fidelity call set refines previous population-based associations of CHIP with incident outcomes. For example, the annualized incidence of myeloid malignancy in individuals with small CHIP clones is 0.03% per year, which increases to 0.5% per year among individuals with very large CHIP clones. We also find a significantly lower prevalence of CHIP in individuals of self-reported Latino or Hispanic ethnicity in All of Us, highlighting the importance of including diverse populations. The standardization of CHIP calling will increase the fidelity of CHIP epidemiological work and is required for clinical CHIP diagnostic assays
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Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.
- Author
- Aguet François
- Ardlie Kristin
- Bick Alexander
- Ebert Benjamin
- Fidler Trevor
- Gibson Christopher
- Griffin Gabriel
- Heard-Costa Nancy
- Heimlich J
- Jaiswal Siddhartha
- Levy Daniel
- Libby Peter
- Mack Taralynn
- Nakao Tetsushi
- Natarajan Pradeep
- Niroula Abhishek
- Peloso Gina
- Rich Stephen
- Rotter Jerome
- Ruan Yunfeng
- Tall Alan
- Taylor Kent
- Uddin Md
- Vasan Ramachandran
- Vlasschaert Caitlyn
- Wang Yuxuan
- Yu Zhi
- Zekavat Seyedeh
- Publication venue
- eScholarship, University of California
- Publication date
- 15/09/2023
- Field of study
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVDs), putatively via inflammasome activation. We pursued an inflammatory gene modifier scan for CHIP-associated CVD risk among 424,651 UK Biobank participants. We identified CHIP using whole-exome sequencing data of blood DNA and modeled as a composite, considering all driver genes together, as well as separately for common drivers (DNMT3A, TET2, ASXL1, and JAK2). We developed predicted gene expression scores for 26 inflammasome-related genes and assessed how they modify CHIP-associated CVD risk. We identified IL1RAP as a potential key molecule for CHIP-associated CVD risk across genes and increased AIM2 gene expression leading to heightened JAK2- and ASXL1-associated CVD risk. We show that CRISPR-induced Asxl1-mutated murine macrophages had a particularly heightened inflammatory response to AIM2 agonism, associated with an increased DNA damage response, as well as increased IL-10 secretion, mirroring a CVD-protective effect of IL10 expression in ASXL1 CHIP. Our study supports the role of inflammasomes in CHIP-associated CVD and provides evidence to support gene-specific strategies to address CHIP-associated CVD risk
Size and Distribution of Market Benefits From Adopting Biotech Crops
- Author
- _____
- _____
- _____
- _____
- _____
- _____
- _____
- _____
- _____
- C James
- C R Stark
- D E Ervin
- D W Larson
- E Golan
- E H Glade
- Economic _____
- G Frisvold
- G Moschini
- G Moschini
- Gregory Price
- J B Falck-Zepeda
- J Carpenter
- J Fernandez-Cornejo
- J Fernandez-Cornejo
- J M Alston
- J M Alston
- J P Houck
- J Rawlinson
- J Sullivan
- J W Gibson
- J W Mullins
- Jorge Fernandez-Cornejo
- José Benjamin Falck-Zepeda
- K Smith
- K Smith
- L A Meyer
- L P Gianessi
- L P Gianessi
- M Duffy
- M Marra
- M W Williams
- N D Uri
- P A Duffy
- P Pinstrup-Andersen
- R E Heimlich
- R M Rejesus
- R Paarlberg
- Virginia Cooperative Extension
- W D Mcbride
- W E Huffman
- W Lin
- W Lin
- William W. Lin
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2003
- Field of study
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- RF Jenefsky
- RG Alsmiller Jr.
- RG Arnold
- RG Bishop
- RG Johnson
- RG Kulkarni
- RG Markham
- RG Markham
- RG Robertson
- RG Robinson
- RG Schneggenburger
- RG Stokstad
- RG Stokstad
- RG Stokstad
- RH Parker
- RH Spear
- RI Tarara
- RJ Burt
- RJ Dupzyk
- RJ Girnius
- RJ Holt
- RJ Holt
- RJ Holt
- RJ Holt
- RJ Mason
- RJ Meijer
- RJ Mitchell
- RJ Peterson
- RJ Peterson
- RJ Schneider
- RJ Sparks
- RJ Sparks
- RJ Sparks
- RK Bhowmik
- RK Jolly
- RK Srinivasa
- RK Tenhaken
- RL Anderson
- RL Anderson
- RL Auble
- RL Blanchard
- RL Crawley
- RL Gill
- RL Macklin
- RL Macklin
- RL Meek
- RL Mlekodaj
- RL Robinson
- RL Robinson
- RL Walraven
- RL White
- RL Whitman
- RL Wolke
- RM Chaudhri
- RM Delvecchio
- RM Freeman
- RM Hutcheon
- RM Lambrecht
- RM Prior
- RM Ronningen
- RM Ronningen
- RM Ronningen
- RM Sealock
- RM Strang
- RM Vecchio
- RM Wieland
- RN Boyd
- RO Sayer
- RP Dinardo
- RP Lawson
- RP Singhal
- RP Singhal
- RR Betts
- RR Betts
- RR Borchers
- RR Bourgoignie
- RR Doering
- RR Fullwood
- RR Fullwood
- RR Johnson
- RR Johnson
- RR Sercely
- RR Silbar
- RR Spencer
- RR Spencer
- RR Stone
- RR Wilson
- RR Wilson
- RS Hickman
- RS Hicks
- RS Revell
- RS Simon
- RS Timsit
- RS Timsit
- RS Timsit
- RT Santoro
- RT Santoro
- RW Adam
- RW Benjamin
- RW Berry
- RW Bickes Jr.
- RW Dressel
- RW Finlay
- RW Hockenbury
- RY Cusson
- S Agarwal
- S Ahmad
- S Andre
- S Barshay
- S Bederka
- S Biswas
- S Bjornholm
- S Cierjacks
- S Cierjacks
- S Cierjacks
- S Cochavi
- S Cotelle
- S Datz
- S Davis
- S Diliberto
- S Dushman
- S Dushman
- S El-Kazzaz
- S Frankel
- S Frankel
- S Furui
- S Furui
- S Furyi
- S Gales
- S Gales
- S Gales
- S Gales
- S Gerstenkorn
- S Gorodetzky
- S Grimes
- S Hillebrand
- S Hiramatsu
- S Hlavac
- S Isagawa
- S Iversen
- S Kahane
- S Kato
- S Kato
- S Landowne
- S Lovell
- S Matsuda
- S Matsuki
- S Michalowski
- S Mrozowski
- S Nagy
- S Notarrigo
- S Ogawa
- S Oikawa
- S Pandian
- S Raman
- S Raman
- S Skorka
- S Szalay
- S Takayanagi
- S Takeuchi
- S Takeuchi
- S Tryti
- S Tsai
- S Wynchank
- S Wynchank
- S Yamaji
- S Yamamoto
- SA Azimov
- SA Schiller
- SA Wender
- SA Wender
- SA Wender
- SB Kaufman
- SB Nurushev
- SC Brown
- SE Arnell
- SE Darden
- SF Mughabghab
- SF Tsai
- SG Prussin
- SG Tonapetyan
- SH Chew
- SH Chew
- SH Maxman
- SH Maxman
- SI Anisimov
- SJ Freedman
- SJ Freedman
- SJ Freedman
- SK Ghorai
- SK Saha
- SK Singh
- SK Young
- SL Huang
- SL Tabor
- SL Tabor
- SM Barr
- SM Bilenkii
- SM Flatte
- SM Grimes
- SM Grimes
- SM Kabir
- SM Lee
- SM Polikanov
- SR Cotanch
- SR Smith
- SS Ahmad
- SS Ipson
- SS Kerekatte
- SS Vasil’ev
- SS Verbitskij
- ST Kruger
- ST Thornton
- ST Thornton
- ST Thornton
- SU Eckroad
- SV Artemov
- SV Jackson
- SW Johnsen
- SY Werf
- T Ando
- T Angeleschu
- T Bar-Noy
- T Bauer
- T Bauer
- T Bauer
- T Bowen
- T Bowles
- T Erber
- T Fenyes
- T Hasegawa
- T Hoshino
- T Inamura
- T Inamura
- T Kambara
- T Kikochi
- T Marks
- T Minamisono
- T Minamisono
- T Nishiyama
- T Norimatsu
- T Nozaki
- T Otsubo
- T Paradellis
- T Paradellis
- T Suzuki
- T Takahashi
- T Taylor
- T Taylor
- T Taylor
- T Weckstroem
- T Yamaya
- T Yamaya
- T Yanabu
- TA Boron
- TA Gabriel
- TA Gabriel
- TA Gabriel
- TA Lauritzen
- TE Albert
- TE Cormier
- TE Sampson
- TG Smolyankina
- TH Hsu
- TH Ku
- TH Ku
- TJ Haste
- TK Alexander
- TM Cormier
- TM Cormier
- TM Henderson
- TM Jenkins
- TM Jenkins
- TN Rhodin
- TO Niinikoski
- TP Seitz
- TR Dittrich
- TR Donoghue
- TR Fewell
- TR Fisher
- TR Herold
- TR Merton
- TR Ophel
- TR Ophel
- TR Yeh
- TS Lee
- TS Nazarova
- TS Noggle
- TS Noggle
- TT Bardin
- TU Chan
- TW Chen
- TW Woo
- U Berghaus
- U Brotschi
- U Eberth
- U Fasoli
- U Garg
- U Harz
- U Hauser
- U Kneissl
- U Kneissl
- U Reus
- U Sander
- U Shreter
- U Strohbusch
- UC Corwin
- UN Singh
- UN Singh
- UN Singh
- V Andersen
- V Bechtold
- V Bechtold
- V Bechtold
- V Chabaud
- V Chatoorgoon
- V Chatoorgoon
- V Franco
- V Halpern
- V Koenig
- V Krivan
- V Lantto
- V Manaooli
- V Montelatici
- V Petricek
- V Shkolnik
- V Verdinah
- V Verdingh
- V Verdingh
- V Verdingh
- V Verdingh
- V Verdingh
- V Verdingh
- V Verdingh
- VA Gladyshev
- VB Dedov
- VD Anan’ev
- VD Apokin
- VD Avchukhov
- VD Avchukhov
- VD Bartenev
- VD Bartenev
- VD Bartenev
- VD Scott
- VE Bunakov
- VE Herscovitz
- VE Lewis
- VE Troitskij
- VE Zhucko
- VF Kharchenko
- VG Gorbenko
- VG Karandashov
- VG Polyukhov
- VG Vlasenko
- VG Vorob’eva
- VG Zlobin
- VI Bol’shov
- VI Borovlev
- VI Chigin’
- VI Gridasov
- VI Gridasov
- VI Komarov
- VI Kotov
- VI Petrov
- VI Serov
- VI Strizhak
- VI Strizhak
- VI Strizhak
- VK Daruga
- VM Khvastunov
- VM Kolybasov
- VN Karev
- VN Kononov
- VN Kononov
- VN Kononov
- VN Kononov
- VN Medyanik
- VN Medyanik
- VN Medyanik
- VP Alfimenkov
- VP Badovskii
- VP Bochin
- VP Kovalev
- VP Kovalev
- VP Zrelov
- VS Butsev
- VS Letkhov
- VS Prokopenko
- VT Tustanovskii
- VV Surenyants
- VV Tokarevskij
- VV Varlamov
- VY Golovnya
- W Arnold
- W Ash
- W Assmann
- W Bertozzi
- W Bianco
- W Brueckner
- W Bucher
- W Dietrich
- W Drenckhahn
- W Drenckhahn
- W Eckstein
- W Fitz
- W Forsling
- W Galster
- W Gelletly
- W Henning
- W Kohler
- W Kohler
- W Kreische
- W Kroll
- W Kuhn
- W Kuhn
- W Kutschera
- W Meckback
- W Moller
- W Niessner
- W Parker
- W Schaeffer
- W Smolec
- W Smolec
- W Stach
- W Steckelmacher
- W Steinkilberg
- W Tietsch
- W Tietsch
- W Tornow
- W Trautmann
- W Treu
- W Whaling
- W Wilcke
- W Witsch
- WA Friedman
- WA Gillespie
- WA Schier
- WA Seale
- WA Sedlacek
- WA Sedlacek
- WA Sterrenburg
- WB Cook
- WC Parker
- WC Parker
- WC Parker
- WD Ramsay
- WD Riel
- WD Schmidt-Ott
- WD Westwood
- WE Burcham
- WE Frahn
- WF Schneider
- WG Cross
- WG Davies
- WG Love
- WG Love
- WG Williams
- WH Evans
- WH Mcadams
- WH Wong
- WJ Braithwaite
- WJ Knox
- WJ Lindsey
- WJ Oosterkamp
- WJ Sturm
- WJ Wallace
- WJ Weisehahn
- WK Dagenhart
- WK Dagenhart
- WL Reiter
- WM Currie
- WM Gibson
- WP Alford
- WP Eeghem
- WP Hwang
- WP Hwang
- WP Poenitz
- WP Poenitz
- WR Dixon
- WR Dixon
- WR Falk
- WR Falk
- WR Gibbs
- WR Gibbs
- WR Gibbs
- WR Gibbs
- WR Hering
- WR Phillips
- WR Wylie
- WR Wylie
- WV Conner
- WV Hassenzahl
- Wvander Eijk
- WW Bowman
- WW Daehnick
- WZ Wade
- Y Abgrall
- Y Alexander
- Y Alexander
- Y Avishai
- Y Bornec
- Y Chanut
- Y Chanut
- Y Chanut
- Y Civelekoglu
- Y Dar
- Y Dmitrevskii
- Y Eisen
- Y Eisenberg
- Y Futami
- Y Iwasaki
- Y Kagawa
- Y Kanda
- Y Leduigou
- Y Masri
- Y Shamai
- Y Sugiyama
- Y Suzuki
- Y Uemura
- Y Yamazaki
- Y Yang
- YA Berdnikov
- YA Berezhnoj
- YA Shcherbakov
- YA Volchek
- YD Bayukov
- YG Mashkarov
- YG Sevast’yanov
- YH Shen
- YK Gavrilov
- YP Antuf’ev
- YP Dmitrevskii
- YR Gismatullin
- YS Horowitz
- YS Korotkin
- YT Borzunov
- YT Borzunov
- YT Borzunov
- YT Borzunov
- Yu Gorodkov V
- Yu Sevast’yanov
- YW Lui
- YY Chu
- Z Basrak
- Z Fraenkel
- Z Hulek
- Z Majka
- Z Zinamon
- ZE Switkowski
- ZE Switkowski
- ZE Switkowski
- ZE Switkowski
- ZE Switkowski
- ZG Werner
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1981
- Field of study