1 research outputs found
Iron-Catalyzed Methylation Using the Borrowing Hydrogen Approach
A general iron-catalyzed
methylation has been developed using methanol
as a C1 building block. This borrowing hydrogen approach employs a
Knölker-type (cyclopentadienone)iron carbonyl complex as catalyst
(2 mol %) and exhibits a broad reaction scope. A variety of ketones,
indoles, oxindoles, amines, and sulfonamides undergo mono- or dimethylation
in excellent isolated yields (>60 examples, 79% average yield)