Mixed method joint display to illustrate how quantitative and qualitative data were integrated.

Abbreviations: C, Complementarity; D, Divergence; E, Expansion; NHS, National Health Service; QQD, Quantitizing Qualitative Data. Three themes: 1. Lived experiences, 2. Health seeking and decision making 3. Experiences of hospital.</p

Supplementary data.

Table A Attendance figures compared to study data. Table B Responses to questionnaire compared between the two groups. Table C Quantitizing of the qualitative responses. Table D Quantitizing of qualitative responses around sources of information. (DOCX)</p

PPEDiC survey.

(DOCX)</p

GRAMMS checklist.

(DOCX)</p

Demographic characteristics of all study participants.

Demographic characteristics of all study participants.</p

Conceptual framework including major themes, sub-themes and overarching concepts identified from qualitative data analysis.

Abbreviations: A&E, Accident & Emergency; NHS, National Health Service.</p

Summary characteristics of caregivers interviewed.

Summary characteristics of caregivers interviewed.</p

PPEDiC interview topic guide.

(DOCX)</p

Drug response experiments <i>in vitro</i>.

<p>(<i>Left</i>) Measurement of <i>in vitro</i> cell kill in cell culture for <i>Eμ-myc/Arf-/-</i> and <i>Eμ-myc/p53-/-</i> cells after 48 hours at 50 nM Dox concentration (N.S.: not statistically significant). (Right) Results from a flow cytometry study were used to measure apoptotic cells. <i>Eμ-myc/p53-/-</i> cells are displayed along the top row with <i>Eμ-myc/Arf-/-</i> cells along the bottom; controls (no drug) are in the left column, and drug-treated cells (Dox) are in the right column. For each block, lower left quadrant represents live (proliferating) cells; lower right quadrant shows apoptotic cells; upper right quadrant shows dead cells.</p

Sensitivity analysis results.

<p>Plots of absolute values of sensitivity coefficients for the three parameters for <b>(A)</b> the drug-sensitive cell line, <i>Eμ-myc/Arf-/-</i> and <b>(B)</b> the drug-resistant cell line, <i>Eμ-myc/p53-/-</i>. The range of variation for each parameter is listed in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0129433#pone.0129433.s001" target="_blank">S1 Table</a></b>. <i>S</i> represents sensitivity coefficient.</p