FaSt-SWOT multiplatform experiment raw dataset

[Description of methods used for collection/generation of data] See Pascual et al. (2023, https://doi.org/10.20350/digitalCSIC/15276) and Mourre et al. (2024, https://doi.org/10.20350/digitalCSIC/16077).The data collection was mainly supported by the FaSt-SWOT project, funded by the Spanish Ministry of Science and Innovation, the Spanish Research Agency and the European Regional Development Fund (MCIN/AEI/10.13039/501100011033/FEDER, UE) under Grant Agreement PID2021-122417NB-I00. The project is conducted within the framework of the activities of the Spanish Government through the ”María de Maeztu Centre of Excellence” accreditation to IMEDEA (CSIC-UIB) (CEX2021-001198). The Spanish Ministry of Science and Innovation, the Regional Government of the Balearic Islands and the Spanish Research Council (CSIC) are also acknowledged for their support to the ICTS SOCIB. AP, BM and BBL thank the European Union funding through the EuroSea project, an Horizon 2020 research and innovation programme under grant agreement No 862626. LGN acknowledges funding of her Margarita Salas fellowship by European UnionNextGenerationEU, Ministry of Universities and Recovery, Transformation and Resilience Plan, through a call from the University of the Balearic Islands (Palma, Spain).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001198).ADCP: Leg 1, Leg2.-- CTD: Leg 1, Leg2.-- Drifters: carthe, hereon.-- Gliders: sdeep01, sdeep09.-- GPS: Leg1, Leg2.-- Meteo: Leg1, Leg2.-- MVP: Leg1, Leg2.-- salinity_water_samples.-- Thermosalinograph: Leg1, Leg2.Peer reviewe

Cruise Plan: Fine-Scale ocean currents from integrated multi-platform experiments and numerical simulations: contribution to the new SWOT satellite mission (FaSt-SWOT, PID2021-122417NB-I00)

The FaSt-SWOT project is funded by the Spanish Research Agency and the European Regional Development Fund (AEI/FEDER, UE) under Grant Agreement (PID2021-122417NB-I00). The present research is conducted within the framework of the activities of the Spanish Government through the "María de Maeztu Centre of Excellence'' accreditation to IMEDEA (CSIC-UIB) (CEX2021-001198). The Spanish Ministry of Science and Innovation, the Regional Government of the Balearic Islands and the Spanish Research Council (CSIC) are acknowledged for their support to the ICTS SOCIB. A. P., B. M. and B. B. L. thank the European Union funding through the EuroSea project an Horizon 2020 research and innovation programme under grant agreement No 862626.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001198).Peer reviewe

FaSt-SWOT 2023 Cruise Report

DISPONIBLE PRÓXIMAMENTEThe SWOT satellite mission (Surface Water and Ocean Topography), launched in December 2022, is measuring sea surface height with a resolution an order of magnitude higher than conventional altimeters, providing an unprecedented view of the variability of the sea surface topography. This document reports the activities carried out at sea during the two campaigns of the FaSt-SWOT project (PID2021-122417NB-I00 funded by MCIN/AEI/10.13039/501100011033/ FEDER,UE). These campaigns had two main objectives: 1) participate to the SWOT satellite cal/val activities by collecting in-situ observations of fine-scale structures in the area covered by the satellite during its initial fast-sampling phase, and 2) improve the characterization and understanding of these structures by combining in-situ multi-platform and satellite data with numerical models and other computational techniques. The FaSt-SWOT experiments were conducted in the Balearic Sea (Western Mediterranean Sea) between 25-28 April and 7-10 May 2023, using R/V SOCIB. The experiments consisted in 2 legs both using multi-scale ship-based instruments (CTD, Moving Vessel Profiler, thermosalinograph, ADCP and GoPro action cameras), autonomous platforms (surface drifters and gliders), and satellite observations (SST, ocean color and altimetry). In addition, 2km-resolution data-assimilative modelling simulations were produced to provide a complementary representation of the fine-scale ocean variability. Finally, machine-learning-based optimization algorithms were also tested to define adaptive sampling strategies during the experiment. The sampling first focused on a small anticyclonic eddy, with a diameter around 20-25km. Several cross-sections of the Moving Vessel Profiler and underwater gliders provided insights into the vertical structure of temperature and salinity fields and the associated signals in chlorophyll and dissolved oxygen. Two gliders were programmed to perform back-and-forth sections during a 3-week time with a 1-day delay between them, allowing to evaluate the temporal variability of the ocean fields at the period of repetitivity of the satellite. The second leg started 9 days after the end of the first one. A 48-hour dense radiator-like pattern was performed by R/V SOCIB, allowing to characterize the evolution of the small eddy observed during the first leg. A total of 45 surface drifters were deployed during the two phases to evaluate in-situ surface currents and their associated convergence and divergence in the vicinity of the eddy. This report presents the details of the sampling strategy and collected measurements, also including data management aspects and description of the supporting numerical simulations and external communication activities associated with these field campaigns.FaSt-SWOT project; PID2021-122417NB-I00 funded by MCIN/AEI/10.13039/501100011033/ FEDER,UE.Peer reviewe

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies

Del espacio al Mediterráneo: Persiguiendo corrientes marinas

“Del espacio al Mediterráneo: Persiguiendo corrientes marinas” es un corto documental que recoge la experiencia de las oceanógrafas y oceanógrafos del IMEDEA (CSIC-UIB) y de la ICTS SOCIB durante las dos campañas del proyecto FaSt-SWOT, a bordo del Buque Oceanográfico B/O SOCIB. El objetivo de estas campañas consistió en tomar mediciones de variables y corrientes oceánicas a través de diferentes instrumentos incluyendo plataformas autónomas, como son los planeadores submarinos (gliders) o las boyas de deriva superficiales, para apoyar el análisis y la explotación de las primeras mediciones de alta resolución de la misión satélite SWOT (Surface Water and Ocean Topography o Topografía oceánica y de las aguas superficiales). El satélite SWOT, desarrollado por la NASA y el Centro National de Études Spatiales (CNES), con la contribución de la Agencia Espacial Canadiense y la Agencia Espacial del Reino Unido, fue lanzado al espacio en diciembre de 2022 y orbitará alrededor de la Tierra hasta 2026 para examinar el agua superficial del planeta y la elevación de la superficie marina con alta resolución.Proyecto PID2021-122417NB-I00 (FaSt-SWOT) financiado por MCIN/AEI/10.13039/501100011033 y por FEDER “Una manera de hacer Europa”.Peer reviewe

Non-Invasive Biomarkers for Duchenne Muscular Dystrophy and Carrier Detection

Non-invasive biological indicators of the absence/presence or progress of the disease that could be used to support diagnosis and to evaluate the effectiveness of treatment are of utmost importance in Duchenne Muscular Dystrophy (DMD). This neuromuscular disorder affects male children, causing weakness and disability, whereas female relatives are at risk of being carriers of the disease. A biomarker with both high sensitivity and specificity for accurate prediction is preferred. Until now creatine kinase (CK) levels have been used for DMD diagnosis but these fail to assess disease progression. Herein we examined the potential applicability of serum levels of matrix metalloproteinase 9 (MMP-9) and matrix metalloproteinase 2 (MMP-2), tissue inhibitor of metalloproteinases 1 (TIMP-1), myostatin (GDF-8) and follistatin (FSTN) as non-invasive biomarkers to distinguish between DMD steroid naïve patients and healthy controls of similar age and also for carrier detection. Our data suggest that serum levels of MMP-9, GDF-8 and FSTN are useful to discriminate DMD from controls (p < 0.05), to correlate with some neuromuscular assessments for DMD, and also to differentiate between Becker muscular dystrophy (BMD) and Limb-girdle muscular dystrophy (LGMD) patients. In DMD individuals under steroid treatment, GDF-8 levels increased as FSTN levels decreased, resembling the proportions of these proteins in healthy controls and also the baseline ratio of patients without steroids. GDF-8 and FSTN serum levels were also useful for carrier detection (p < 0.05). Longitudinal studies with larger cohorts are necessary to confirm that these molecules correlate with disease progression. The biomarkers presented herein could potentially outperform CK levels for carrier detection and also harbor potential for monitoring disease progression

Mesoscale and sub-mesoscale vertical exchanges from multi-platform experiments and supporting modelling simulations: anticipating SWOT launch (PRE-SWOT)

This dataset includes published and unpublished in-situ data collected during the PRE-SWOT multi-platform experiment. For details see readme file and cruise report (hdl.handle.net/10261/172644 dx.doi.org/10.20350/digitalCSIC/8584).The PRE-SWOT experiment was conducted onboard R/V García del Cid between 5 and 17 May 2018 in the southern region of the Balearic Islands (western Mediterranean Sea). PRE-SWOT aimed at anticipating the daily high-resolution 2D SSH fields that Surface Water & Ocean Topography (SWOT) will provide during the fast sampling phase after launch in selected areas of the global ocean. This experiment is a contribution to the preparatory SWOT cal/val activities and was coordinated with the PROTEUS-SWOT cruise (R/V Beautemps-Beauprè). The PRE-SWOT project (CTM2016-78607-P) is funded by the Spanish Research Agency and the European Regional Development Fund (AEI/FEDER, UE).Spanish Research Agency and the European Regional Development Fund (AEI/FEDER, UE).Peer reviewe

Coronary artery aneurysms, insights from the international coronary artery aneurysm registry (CAAR).

Coronary Aneurysms are a focal dilatation of an artery segment >1.5-fold the normal size of adjacent segments. Although some series have suggested a prevalence of 0.3-12%, data are lacking. In addition, they are not mentioned in practice guidelines. Our aim was investigate its prevalence, management and long-term outcomes. The coronary artery aneurysm registry (CAAR) involved 32 hospitals across 9 countries in America and Europe. We reviewed 436,467 consecutive angiograms performed over the period 2004-2016. Finally, 1565 patients were recruited. Aneurysm global prevalence was 0.35%. Most patients were male (78.5%) with a mean age of 65 years and frequent cardiovascular risk factors. The main indication for angiogram was an acute coronary syndrome, 966 cases. The number of aneurisms was ≤2 per patient in 95.8% of the cases, mostly saccular, most frequently found in the left anterior descending and with numbers proportional with coronary stenosis. Aortopathies were related with more aneurysms too. Most patients received any revascularization procedure (69%), commonly percutaneous (53%). After a median follow-up of 37.2 months, 485 suffered a combined event (MACE) and 240 died. Without major differences comparing CABG vs PCI, MACE and death were more frequent in patients who received bare metal stents. Coronary artery aneurysms are not uncommon. Usually, they are associated with coronary stenosis and high cardiovascular risk. Antiplatelet therapy seems reasonable and a percutaneous approach is safe and effective