ELM diagnostic sensitivity and specificity derived from various analysis models.

<p>ELM diagnostic sensitivity and specificity derived from various analysis models.</p

Variation in ELM diagnostic sensitivity (black triangle) and specificity (blue square) as feature vectors include mean τ₂ values successively from epithelial surface (layer 10) to a lower layer as the cut-off layer.

<p>Optimum sensitivity (94.6%) and specificity (84.3%) were concurrently found at the cut-off layer of 6.</p

Distribution of mean τ₂ in all divided 10 layers for normal (black square) and precancerous (red circle) samples.

<p>Here, the mean τ_<b>2</b> for each pathological state was calculated from the sample pool which includes 10 normal, 8 CIN1, 6 CIN2 and 8 CIN3 cervical tissue sections and the averaged relative standard deviation (RSD) was calculated to be 18% for all categories. More details regarding error bars are clarified in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125706#pone.0125706.s005" target="_blank">S5 Fig</a>.</p

Distribution profiles of mean τ₂ in divided layer 1 (■), layer 2 (▲) and layer 3 (●) of epithelium against pathological states of Normal, CIN1, CIN2 and CIN3.

<p>Here, the mean τ_<b>2</b> for each pathological state was calculated from the sample pool which includes 10 normal, 8 CIN1, 6 CIN2 and 8 CIN3 cervical tissue sections and the averaged relative standard deviation (RSD) was calculated to be 15% for all categories. More details regarding error bars are elucidated in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125706#pone.0125706.s003" target="_blank">S3 Fig</a>.</p

Distribution of mean lifetime τ₂ in lower half layers (□-layer 1, ◯-layer 2, △-layer 3, ▽-layer 4, ◇-layer 5) and top half layers (6–10) of epithelium as tissues progress from normal to various CIN grades.

<p>Here, the mean τ_<b>2</b> for each pathological state was calculated from the sample pool which includes 10 normal, 8 CIN1, 6 CIN2 and 8 CIN3 cervical tissue sections and the averaged relative standard deviation (RSD) was calculated to be 20% for all categories. More details regarding error bars are clarified in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125706#pone.0125706.s004" target="_blank">S4 Fig</a>.</p