623 research outputs found

    Novel enteric viruses in fatal enteritis of grey squirrels

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    Anisotropy in high-frequency broadband acoustic backscattering in the presence of turbulent microstructure and zooplankton

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    Author Posting. © Acoustical Society of America, 2012. This article is posted here by permission of Acoustical Society of America for personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 132 (2012): 670-679, doi:10.1121/1.4730904.High-frequency broadband (120–600 kHz) acoustic backscattering measurements have been made in the vicinity of energetic internal waves. The transducers on the backscattering system could be adjusted so as to insonify the water-column either vertically or horizontally. The broadband capabilities of the system allowed spectral classification of the backscattering. The distribution of spectral shapes is significantly different for scattering measurements made with the transducers oriented horizontally versus vertically, indicating that scattering anisotropy is present. However, the scattering anisotropy could not be unequivocally explained by either turbulent microstructure or zooplankton, the two primary sources of scattering expected in internal waves. Daytime net samples indicate a predominance of short-aspect-ratio zooplankton. Using zooplankton acoustic scattering models, a preferential orientation of the observed zooplankton cannot explain the measured anisotropy. Yet model predictions of scattering from anisotropic turbulent microstructure, with inputs from coincident microstructure measurements, were not consistent with the observations. Possible explanations include bandwidth limitations that result in many spectra that cannot be unambiguously attributed to turbulence or zooplankton based on spectral shape. Extending the acoustic bandwidth to cover the range from 50 kHz to 2 MHz could help improve identification of the dominant sources of backscattering anisotropy

    The Global Health Security index and Joint External Evaluation score for health preparedness are not correlated with countries' COVID-19 detection response time and mortality outcome

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    Global Health Security Index (GHSI) and Joint External Evaluation (JEE) are two well-known health security and related capability indices. We hypothesised that countries with higher GHSI or JEE scores would have detected their first COVID-19 case earlier, and would experience lower mortality outcome compared to countries with lower scores. We evaluated the effectiveness of GHSI and JEE in predicting countries' COVID-19 detection response times and mortality outcome (deaths/million). We used two different outcomes for the evaluation: (i) detection response time, the duration of time to the first confirmed case detection (from 31st December 2019 to 20th February 2020 when every country's first case was linked to travel from China) and (ii) mortality outcome (deaths/million) until 11th March and 1st July 2020, respectively. We interpreted the detection response time alongside previously published relative risk of the importation of COVID-19 cases from China. We performed multiple linear regression and negative binomial regression analysis to evaluate how these indices predicted the actual outcome. The two indices, GHSI and JEE were strongly correlated (r = 0.82), indicating a good agreement between them. However, both GHSI (r = 0.31) and JEE (r = 0.37) had a poor correlation with countries' COVID-19–related mortality outcome. Higher risk of importation of COVID-19 from China for a given country was negatively correlated with the time taken to detect the first case in that country (adjusted R2 = 0.63–0.66), while the GHSI and JEE had minimal predictive value. In the negative binomial regression model, countries' mortality outcome was strongly predicted by the percentage of the population aged 65 and above (incidence rate ratio (IRR): 1.10 (95% confidence interval (CI): 1.01–1.21) while overall GHSI score (IRR: 1.01 (95% CI: 0.98–1.01)) and JEE (IRR: 0.99 (95% CI: 0.96–1.02)) were not significant predictors. GHSI and JEE had lower predictive value for detection response time and mortality outcome due to COVID-19. We suggest introduction of a population healthiness parameter, to address demographic and comorbidity vulnerabilities, and reappraisal of the ranking system and methods used to obtain the index based on experience gained from this pandemic

    UK Waste Sector COVID-19 Response and Resilience Report

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    This is the final version. Available from the Covid-19 Waste Project website via the link in this recordFrom the beginning of March 2020, when COVID-19 was confirmed as a pandemic by World Health Organization, many sectors across the UK had to respond to an uncertain and rapidly evolving situation, including the introduction of a UK-wide lockdown on the 23rd March. The resources and waste sector, as a frontline service that protects both human health and the environment, had to maintain operations and this necessitated contingency planning on an unforeseen scale, with significant cross-sector engagement and collaboration, and new methods of working. To capture some of the learning from the first six months after the start of the UK-wide lockdown, the Chartered Institution of Wastes Management (CIWM) has been working in partnership with the University of Exeter to undertake a UK wide research exercise with multiple stakeholders across the resources and waste management sector. This forms part of a wider project led by the University of Exeter and funded by the Economic and Social Research Council, as part of UK Research and Innovation’s Rapid Response to COVID-19. The study used a qualitative social science methodology, undertaking a series of workshops and in-depth interviews with representatives from across the sector. Participants included national and local government officers, environmental regulators, and local authority and private sector waste professionals. Held in October 2020, this stakeholder engagement exercise explored immediate challenges, winter preparedness, and what is needed to support longer term sector resilience. It should be noted that this report is based on the discussions and feedback from sector representatives who generously took part. It is not designed to be a comprehensive assessment or account of the sector’s response but rather a snapshot in time during Autumn 2020 as the UK readied itself for the likelihood of a second wave of COVID-19 through the winter months. Much of the data and evidence that will be needed for a thorough assessment of the full impact of the pandemic on the sector is not yet available, but this report is designed to be a first step in the process to stimulate further reflection and learning.Economic and Social Research Council (ESRC

    Three-dimensional modeling of acoustic backscattering from fluid-like zooplankton

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    Author Posting. © Acoustical Society of America, 2002. This article is posted here by permission of Acoustical Society of America for personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 111 (2002): 1197-1210, doi:10.1121/1.1433813.Scattering models that correctly incorporate organism size and shape are a critical component for the remote detection and classification of many marine organisms. In this work, an acoustic scattering model has been developed for fluid-like zooplankton that is based on the distorted wave Born approximation (DWBA) and that makes use of high-resolution three-dimensional measurements of the animal's outer boundary shape. High-resolution computerized tomography (CT) was used to determine the three-dimensional digitizations of animal shape. This study focuses on developing the methodology for incorporating high-resolution CT scans into a scattering model that is generally valid for any body with fluid-like material properties. The model predictions are compared to controlled laboratory measurements of the acoustic backscattering from live individual decapod shrimp. The frequency range used was 50 kHz to 1 MHz and the angular characteristics of the backscattering were investigated with up to a 1° angular resolution. The practical conditions under which it is necessary to make use of high-resolution digitizations of shape are assessed.This work was supported in part by the Woods Hole Oceanographic Institution Education Office

    Combination antiretroviral therapy and the risk of myocardial infarction

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    Congenital nephrotic syndrome

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    Congenital nephrotic syndrome (CNS) is a rare kidney disorder characterized by heavy proteinuria, hypoproteinemia, and edema starting soon after birth. The majority of cases are caused by genetic defects in the components of the glomerular filtration barrier, especially nephrin and podocin. CNS may also be a part of a more generalized syndrome or caused by a perinatal infection. Immunosuppressive medication is not helpful in the genetic forms of CNS, and kidney transplantation is the only curative therapy. Before the operation, management of these infants largely depends on the magnitude of proteinuria. In severe cases, daily albumin infusions are required to prevent life-threatening edema. The therapy also includes hypercaloric diet, thyroxin and mineral substitution, prevention of thrombotic episodes, and prompt management of infectious complications. The outcome of CNS patients without major extrarenal manifestations is comparable with other patient groups after kidney transplantation

    Sleep and Fatigue Symptoms in Children and Adolescents With CKD: A Cross-sectional Analysis From the Chronic Kidney Disease in Children (CKiD) Study

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    Although symptoms of sleepiness and fatigue are common among adults with Chronic Kidney Disease (CKD), little is known about the prevalence of these symptoms in children with CKD
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